New Study on Trobalt/Maxipost in Relation to SHL-induced Tinnitus

Discussion in 'Research News' started by attheedgeofscience, May 11, 2015.

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    1. attheedgeofscience
      Uninvolved

      attheedgeofscience Member Hall of Fame

      Location:
      Denmark
      Tinnitus Since:
      Childhood
      Cause of Tinnitus:
      Head Injury
      The following very recent finding from an animal model may have implications for Trobalt and its therapeutic potential on the treatment of symptoms of tinnitus. I will try to find out more.
       
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    2. Philemon

      Philemon Member Benefactor

      Location:
      France/Switzerland
      Tinnitus Since:
      05/2014
      Cause of Tinnitus:
      Mild NIHL
      Here's the article if you need it
       

      Attached Files:

      • Helpful Helpful x 1
    3. nills
      Barefooter

      nills Member Benefactor

      Location:
      Belgium
      Tinnitus Since:
      11/2009
      Cause of Tinnitus:
      acoustic trauma
      from article

      "RTG would suppress low-frequency tinnitus, 123
      while Maxipost, in contrast, would suppress high frequency 124
      tinnitus. Since SS is believed to induce a high pitched tinnitus 125
       
    4. erik
      Breezy

      erik Manager Staff Benefactor

      Location:
      Washington State, USA
      Tinnitus Since:
      04/15/2012
      Cause of Tinnitus:
      Most likely hearing loss
      Sounds like a preventative treatment rather than one for chronic T....or am I reading this incorrectly
       
    5. Nucleo

      Nucleo Member Benefactor

      Tinnitus Since:
      02/2011
      Yeah from the way this is written it sounds like that.

      However the take home message is researchers show playing around with K+ channel functions directly affect the auditory system of animals after it is damaged. This shows more promise than anything else really.
       
    6. erik
      Breezy

      erik Manager Staff Benefactor

      Location:
      Washington State, USA
      Tinnitus Since:
      04/15/2012
      Cause of Tinnitus:
      Most likely hearing loss
      Let's hope so. They have been talking about Potassium channels and T for years now and they are still playing around with mice and chinchillas. I found articles linking this over 7 years old now
       
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    7. attheedgeofscience
      Uninvolved

      attheedgeofscience Member Hall of Fame

      Location:
      Denmark
      Tinnitus Since:
      Childhood
      Cause of Tinnitus:
      Head Injury
      The reason I posted the information further up was because the animal-study was brought to my attention by the Tinnitus Research Initiative which has submitted a manuscript to the journal "Expert Opinion On Pharmacotherapy" based - in part - on participants who volunteered their experience with Trobalt as pertains to efficacy in relation to treatment of symptoms of tinnitus. The animal-study may help explain why some participants of the informal trial here on TT saw better improvements than others re:

      "However when Maxipost or RTG were administered with SS, Maxipost prevented the SS-reduced CAP amplitudes at high frequencies (≥20 kHz) and RTG prevented SS-reduced CAP amplitudes at low frequencies (≤8 kHz)."

      The above, therefore, represents a dichotomy in the treatment potential and could be explored further either retrospectively, or going forward with other volunteers.

      The reason I posted the article had nothing to do with the basic overall efficacy of Trobalt, but instead because of the specific finding as quoted.

      attheedgeofscience
      12/MAY/2015.
       
    8. locoyeti
      Sunshine

      locoyeti Member Benefactor

      Tinnitus Since:
      2/2014

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    9. Atlantis

      Atlantis Member

      Tinnitus Since:
      02/2014
      It's good rats get relief from tinnitus!
       
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