New Study on Trobalt/Maxipost in Relation to SHL-induced Tinnitus

Discussion in 'Research News' started by attheedgeofscience, May 11, 2015.

    1. attheedgeofscience
      No Mood

      attheedgeofscience Member Mighty Benefactor Hall of Fame

      Location:
      Denmark
      Tinnitus Since:
      Resolved since 2016
      Cause of Tinnitus:
      See information page
      The following very recent finding from an animal model may have implications for Trobalt and its therapeutic potential on the treatment of symptoms of tinnitus. I will try to find out more.
       
      • Like Like x 5
      • Informative Informative x 1
    2. Philemon

      Philemon Member Benefactor

      Location:
      France/Switzerland
      Tinnitus Since:
      05/2014
      Cause of Tinnitus:
      Mild NIHL
      Here's the article if you need it
       

      Attached Files:

      • Helpful Helpful x 1
    3. nills
      Barefooter

      nills Member Benefactor

      Location:
      Belgium
      Tinnitus Since:
      11/2009
      Cause of Tinnitus:
      acoustic trauma
      from article

      "RTG would suppress low-frequency tinnitus, 123
      while Maxipost, in contrast, would suppress high frequency 124
      tinnitus. Since SS is believed to induce a high pitched tinnitus 125
       
    4. erik
      Cool

      erik Member Benefactor Hall of Fame

      Location:
      Washington State, USA
      Tinnitus Since:
      04/15/2012 or earlier?
      Cause of Tinnitus:
      Most likely hearing loss
      Sounds like a preventative treatment rather than one for chronic T....or am I reading this incorrectly
       
    5. Nucleo

      Nucleo Member Benefactor

      Tinnitus Since:
      02/2011
      Yeah from the way this is written it sounds like that.

      However the take home message is researchers show playing around with K+ channel functions directly affect the auditory system of animals after it is damaged. This shows more promise than anything else really.
       
    6. erik
      Cool

      erik Member Benefactor Hall of Fame

      Location:
      Washington State, USA
      Tinnitus Since:
      04/15/2012 or earlier?
      Cause of Tinnitus:
      Most likely hearing loss
      Let's hope so. They have been talking about Potassium channels and T for years now and they are still playing around with mice and chinchillas. I found articles linking this over 7 years old now
       
      • Agree Agree x 1
    7. AUTHOR
      AUTHOR
      attheedgeofscience
      No Mood

      attheedgeofscience Member Mighty Benefactor Hall of Fame

      Location:
      Denmark
      Tinnitus Since:
      Resolved since 2016
      Cause of Tinnitus:
      See information page
      The reason I posted the information further up was because the animal-study was brought to my attention by the Tinnitus Research Initiative which has submitted a manuscript to the journal "Expert Opinion On Pharmacotherapy" based - in part - on participants who volunteered their experience with Trobalt as pertains to efficacy in relation to treatment of symptoms of tinnitus. The animal-study may help explain why some participants of the informal trial here on TT saw better improvements than others re:

      "However when Maxipost or RTG were administered with SS, Maxipost prevented the SS-reduced CAP amplitudes at high frequencies (≥20 kHz) and RTG prevented SS-reduced CAP amplitudes at low frequencies (≤8 kHz)."

      The above, therefore, represents a dichotomy in the treatment potential and could be explored further either retrospectively, or going forward with other volunteers.

      The reason I posted the article had nothing to do with the basic overall efficacy of Trobalt, but instead because of the specific finding as quoted.

      attheedgeofscience
      12/MAY/2015.
       
    8. locoyeti
      Sunshine

      locoyeti Member Benefactor

      Tinnitus Since:
      2/2014

      Attached Files:

    9. Atlantis

      Atlantis Member

      Tinnitus Since:
      02/2014
      It's good rats get relief from tinnitus!
       
      • Like Like x 1
      • Funny Funny x 1

Share This Page

Loading...