Onset-Related Differences in Neural Substrates of Tinnitus-related Distress

daedalus · Oct 24, 2013

Onset-related differences in neural substrates of tinnitus-related distress: the anterior cingulate cortex in late-onset tinnitus, and the frontal cortex in early-onset tinnitus.
Song JJ, Vanneste S, Schlee W, Van de Heyning P, De Ridder D.
Source
Department of Otorhinolaryngology-Head and Neck Surgery, Seoul National University Hospital, Yun-Kun Dong 28, Chong-No Gu, Seoul, 110-744, Korea, jjsong96@gmail.com.

Abstract
Recent findings regarding differences in tinnitus-related neural activity according to onset age have raised a question on possible onset age-related differences in neural substrates of distress. Hence we collected quantitative electroencephalography (qEEG) findings of 28 late-onset tinnitus (LOT) and 29 early-onset tinnitus (EOT) (mean onset age 52.3 and 29.0 years, respectively) participants. According to the tinnitus questionnaire (TQ) score grade, LOTs were then subdivided into 13 high distress (HD; TQ grade 3 or 4) and 15 low distress (LD; TQ grade 1 or 2), while EOTs into 14 HD and 15 LD. Compared to the EOT group, the LOT group demonstrated increased qEEG source-localized activity and functional connectivity primarily in the anterior cingulate cortex (ACC) and parahippocampus. In subgroup comparisons, the ACC was activated more in HD-LOT participants than in LD-LOT participants for the beta 1, beta 2 and gamma frequency bands, while the left orbitofrontal cortex and left dorsolateral prefrontal cortex were activated more in HD-EOT than in LD-EOT for the delta/beta and gamma frequency bands, respectively. Even with the same amount of tinnitus-related distress level, responsible neural substrates are different according to the onset age. These differences may be important for exploring different target areas of treatment according to tinnitus onset age, as well as for conducting similar studies on other pathologies, such as depression or pain.
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In short, that means the brain activity related to tinnitus differs depending of the age of onset. And future treatments, at least brain stimulation based ones, will take that into account. They are refining their models.

Erlend · Oct 24, 2013

Does this give more or less hope for people who got it while being young? I'm 19, was 18 when I got it, 5 months ago. The sound has changed, some has gone away and returned.

Jake · Oct 24, 2013

thats a good question @Erlend. Being 21, we're kind of in the same boat. Hopefully us being young when we got T will help us out in the future.

Hudson · Oct 25, 2013

I got tinnitus when I was 17. I'm 27 now. I don't feel like it has benefited me in any way to have it young. lol

James White · Oct 25, 2013

some are even born with tinnitus i think

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Onset-Related Differences in Neural Substrates of Tinnitus-related Distress

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Onset-Related Differences in Neural Substrates of Tinnitus-related Distress

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daedalus Member

Erlend Member Benefactor

Jake Member

Hudson Member Benefactor

James White Member Benefactor

Head Related Trauma Delayed Onset Tinnitus from Automobile Accident

Sudden Onset of Fluctuating Pulsatile Tinnitus — Yawning Can Stop It for a Few Seconds

Sailor's Tinnitus Onset After Ear Infection

Recent Onset of Tinnitus, Potential Causes: Lexapro/Bupropion, Allergies/Sinuses Acting Up

Recent Onset or Awareness of Bilateral Tinnitus

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