Plastic Changes in Glycine and GABA after Ossicle Removal and Cochlear Ablation

Discussion in 'Research News' started by tomm, Dec 14, 2014.

tinnitus forum
    1. tomm
      Thinking

      tomm Member Benefactor

      Location:
      London, UK
      Tinnitus Since:
      10/2014
      Cause of Tinnitus:
      Acoustic trauma (club drumming)
      http://www.sciencedirect.com/science/article/pii/S0014488698968121

      GABA release was elevated persistently after ossicle removal. After cochlear ablation, release was elevated at 5 days, near the control at 59 days, and elevated again at 145 days. After both lesions, glycine uptake was elevated bilaterally in the CN and medial superior olive. GABA uptake became depressed by 59 or 145 days bilaterally in the auditory midbrain. These changes may stem from regulation and may contribute to mechanisms that generate symptoms such as loudness recruitment and tinnitus, which often accompany hearing loss.

      Two lengths of time appear repeatedly. 2 months, and 5 months. Might be where some of the acute and post-acute dates come from.
       
      • Informative Informative x 1

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