Selective Ablation of Nociceptive Neurons to Eliminate Hyperalgesia and Neurogenic Inflammation

This is an old article but still very interesting.

I would not know if injecting Resiniferatoxin (RTX) into the inner ear would also destroy other cells besides type II afferents,

But if there was some sort of receptor uniquely expressed on type II afferents and a toxin that could selectively destroy cells with that receptor, maybe it could be a treatment option for tinnitus and especially noxacusis, if type II afferents are indeed the culprit.

→ Selective ablation of nociceptive neurons for elimination of hyperalgesia and neurogenic inflammation

 

Here's an article from 2023 which mentions that RTX can also be used to desensitize neurons instead of ablating them:

There are currently clinical trials going on for bladder pain, cancer pain, and knee osteoarthritis.