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I voted for 3.
Three notes in response.
1. I do not support TRT.
2. You're right in that I do not pour through research notes. However I also do not feel an obligation to.
But most importantly three...
3. I'm cynical. Getting one's hopes up is a recipe to be let down, especially when your happiness depends on it. That's not to say we should accept misery. I grow tired of medical research articles talking about exciting new things that would help people and then nothing ever seemingly ever comes of it.
I'm sure it's fine, though. Just like male birth control.