Reinnervation of Hair Cells by Auditory Neurons

Discussion in 'Research News' started by tomm, Dec 18, 2014.

    1. tomm

      tomm Member Benefactor

      London, UK
      Tinnitus Since:
      Cause of Tinnitus:
      Acoustic trauma (club drumming)
      From 2006.

      "Hearing loss can be caused by primary degeneration of spiral ganglion neurons or by secondary degeneration of these neurons after hair cell loss. The replacement of auditory neurons would be an important step in any attempt to restore auditory function in patients with damaged inner ear neurons or hair cells.

      [...] We therefore used the denervated organ of Corti for the study of neuronal regeneration and synaptogenesis with hair cells and found that spiral ganglion neurons obtained from the cochlea of an untreated newborn mouse reinnervated hair cells in the toxin-treated organ of Corti and expressed synaptic vesicle markers at points of contact with hair cells. These findings suggest that it may be possible to replace degenerated neurons by grafting new cells into the organ of Corti."
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    2. skoupidis

      skoupidis Member

      Tinnitus Since:
      Cause of Tinnitus:
      Acoustic trauma or mvc
      Any current updates on this?

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