Tinnitus: Causes and Clinical Management (The Lancet Neurology)

Discussion in 'Research News' started by daedalus, Sep 1, 2013.

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    1. daedalus

      daedalus Member

      Location:
      Brussels
      Tinnitus Since:
      04/2007
      Apparently it is rare enough to be considered a cause of celebration by the Tinnitus Research Initiative. Of course it is owned by the evil Elsevier. Two things worth to mention: neuromodulation is evoked and De Ridder hasn't dropped tinnitus research after his move to New Zealand. There was a misunderstanding with my last post so i post this again. Enjoy. The important part is it is posted in a well known journal. The "it's not otological but neurological" and "direct brain stimulation can help" are IMHO important message to spread so other neuroscientists hop in the bandwagon. Right now tinnitus research is very confidential and seems to be overshadowed by the "oh it's psychological there nothing to do medically" type of discourse.

      Tinnitus: causes and clinical management.

      Langguth B, Kreuzer PM, Kleinjung T, De Ridder D.
      Source

      Department of Psychiatry and Psychotherapy, University of Regensburg, Regensburg, Germany; Interdisciplinary Tinnitus Center, University of Regensburg, Regensburg, Germany. Electronic address: berthold.langguth@medbo.de.
      Abstract

      Tinnitus is the perception of sound in the absence of a corresponding external acoustic stimulus. With prevalence ranging from 10% to 15%, tinnitus is a common disorder. Many people habituate to the phantom sound, but tinnitus severely impairs quality of life of about 1-2% of all people. Tinnitus has traditionally been regarded as an otological disorder, but advances in neuroimaging methods and development of animal models have increasingly shifted the perspective towards its neuronal correlates. Increased neuronal firing rate, enhanced neuronal synchrony, and changes in the tonotopic organisation are recorded in central auditory pathways in reaction to deprived auditory input and represent-together with changes in non-auditory brain areas-the neuronal correlate of tinnitus. Assessment of patients includes a detailed case history, measurement of hearing function, quantification of tinnitus severity, and identification of causal factors, associated symptoms, and comorbidities. Most widely used treatments for tinnitus involve counselling, and best evidence is available for cognitive behavioural therapy. New pathophysiological insights have prompted the development of innovative brain-based treatment approaches to directly target the neuronal correlates of tinnitus.

      There is another paper in the lancet by Baguley et al but it mentions only psychology and sound therapy.
       
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    2. Hudson
      Cowboy

      Hudson Member Benefactor

      Tinnitus Since:
      2003
      I'd like to see what they mention about new insights that are prompting new treatments.
       
    3. erik
      Breezy

      erik Manager Staff Benefactor

      Location:
      Washington State, USA
      Tinnitus Since:
      04/15/2012
      Cause of Tinnitus:
      Most likely hearing loss
      I second that Hudson. I think that we with T, all know it was more of a brain thing than an ear thing, so not sure why this is such a revelation except for De Ridder and Langguth who have always claimed this.

      Maybe, it's the that fact they all finally agree on the neuro aspect, disorder and cause of T. Nonetheless, it is great news. Now that they all agree, they can collaborate and work to finding more effective treatments to go along with neuro stimulation. This news does also correlate with Microtransponder report from TRI and the recent announcing of 3 Microtransponder brain stimulation studies.

      Thanks daedalus!
       
    4. Hopeful
      Wishful

      Hopeful Member Benefactor

      Tinnitus Since:
      06/13
      @erik

      Do you have any overview how much work there has been done in combining nerve and sound stimulation? In how many ways has this been tried?
       
    5. James White
      Anime

      James White Member Benefactor

      Location:
      Toulouse, France
      Tinnitus Since:
      April 2013
      Cause of Tinnitus:
      Maybe loud music. Not sure.
      They have been doing it for quite a lot of time on lab mice, they did a phase1 clinical study in belgium for which they had not perfect but quite good results. I think microtransponder is the only company seriously into that technology today.
       
    6. erik
      Breezy

      erik Manager Staff Benefactor

      Location:
      Washington State, USA
      Tinnitus Since:
      04/15/2012
      Cause of Tinnitus:
      Most likely hearing loss
      Yes, they have been doing this for a while, at least the past 5-6 years. But the treatment is very invasive as they have to implant a device into your head behind the ear to do the stimulation and this is only in very limited use so the data is not really there. Perhaps now that there is something of a consensus, there will be more studies.
       
    7. James White
      Anime

      James White Member Benefactor

      Location:
      Toulouse, France
      Tinnitus Since:
      April 2013
      Cause of Tinnitus:
      Maybe loud music. Not sure.

      the device is implanted in the chest not the ear, it targets the vagus nerve. I guess preliminary models are invasive but if their device works as expected, they'll probably have some less invasive technology to build
       
    8. erik
      Breezy

      erik Manager Staff Benefactor

      Location:
      Washington State, USA
      Tinnitus Since:
      04/15/2012
      Cause of Tinnitus:
      Most likely hearing loss
      Yes, I did get that a little confused with TMS. I was thinking more about the Dirk DeRidder's TMS stimulation where they do implant a device from behind the ear into the head/brain and then electrically stimulate it. It was discussed in the BBC documentary "Longing For Silence" here: https://www.tinnitustalk.com/threads/recommended-listen-bbc-longing-for-silence.705/. Even though it is a few years old, it is a good listen.
       
    9. Dhaval
      Buzzed

      Dhaval Member

      Tinnitus Since:
      4 months
      Wow! There are just so many approaches being tried. Yet they are to categorize which treatment would work for what. I think vns stimulation would suit more for ppl with non cochlear tinnitus. Although then they don't describe the patients history any where.
       

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