Tinnitus Control by Dopamine Agonist Pramipexole in Presbycusis Patients

Discussion in 'Research News' started by rogerg, Mar 30, 2011.

    1. Alue
      No Mood

      Alue Member

      Tinnitus Since:
      01/2016
      Cause of Tinnitus:
      Acoustic Trauma
      @Nick Pyzik

      We're pretty much in agreement with the likely causes. I think I have had a similar experience as you as well only I'm a month in and mine was caused by a short acoustic trauma.

      It may well be a lot of causes (medication, deterioration from past noise trauma, stress, etc.) that eventually sets off this cascade, so that one last noise could well be the perfect combination of things or the straw that broke the camel's back.

      I have heard that tinnitus is an abnormal brain response to loss of auditory input. It would not surprise me if stress or changes in brain chemistry could interfere with the brain's normal response to this loss of input. Virtually everyone loses some high frequency hearing as they get older, but most people do not get noticeable or intrusive tinnitus.

      What I cannot wrap my head around is why this is so permanent.
       
    2. Nick Pyzik
      Depressed

      Nick Pyzik Member

      Tinnitus Since:
      6/23/15
      Cause of Tinnitus:
      Listening to in-ear headphones & playing in a band
      I believe so. But I don't think anyone else on this site understands me, only a few others. When you say permanent, are you talking about the ringing noise you hear?
       
      • Like Like x 1
    3. Alue
      No Mood

      Alue Member

      Tinnitus Since:
      01/2016
      Cause of Tinnitus:
      Acoustic Trauma
      Yes, the tinnitus being permanent. Hyperacusis seems more likely (although not guaranteed) to subside over time.
       
    4. Tigo

      Tigo Member

      Tinnitus Since:
      2 years
      Cause of Tinnitus:
      genetic hearing loss
      Anyone cured with this treatment ??


      Tinnitus control by dopamine agonist pramipexole in presbycusis patients: a randomized, placebo-controlled, double-blind study.

      Sziklai I1, Szilvássy J, Szilvássy Z.
      Author information

      Abstract
      OBJECTIVES/HYPOTHESIS:
      Since the concept of tinnitus dopaminergic pathway emerged, studies have been proposed to investigate if dopaminergic agents influence tinnitus. We hypothesized that pramipexole, an agonist on D2/D3 receptors, may antagonize tinnitus in the presbycusis patients (in the frequency range of 250 to 8,000 Hz) in a dose schedule accepted for the treatment of Parkinson's disease in elderly people.

      STUDY DESIGN:
      We designed a randomized, prospective, placebo-controlled and double-blind trial.

      METHODS:
      Forty presbycusis patients aged 50 years or older with subjective tinnitus were randomized to two groups (20 patients in both). Patients in the drug group took pramipexole over a period of 4 weeks according to a treatment schedule as follows: week 1, 0.088 mg t.i.d.; week 2, 0.18 mg t.i.d.; week 3, 0.7 mg t.i.d.; week 4, 0.18 mg t.i.d. over 3 days and 0.088 mg t.i.d. the rest of the week. Patients in the second group received placebo. Determination of subjective grading of tinnitus perception, the tinnitus handicap inventory (THI) questionnaire and electrocochleography (ECOG) examinations served as the end points. Subjective audiometry was used to produce secondary data. A significant improvement in tinnitus annoyance is found in the group treated with pramipexole versus placebo with respect to inhibition of tinnitus and a decrease of tinnitus loudness greater than 30 dB. However, neither ECOG nor subjective pure-tone threshold audiometry revealed any change in hearing threshold in response to either pramipexole or placebo.

      CONCLUSIONS:
      Pramipexole is an effective agent against subjective tinnitus associated with presbycusis at a dose schedule used for the treatment of Parkinson's disease. The drug did not change hearing threshold.
       
    5. Marlino
      Cowboy

      Marlino Member

      Location:
      Germany
      Tinnitus Since:
      02/2016
      Cause of Tinnitus:
      unknown
      This sounds to good to be true. How does it come that risky Trobalt is tried so many times by users here and this one not?
       
    6. Marlino
      Cowboy

      Marlino Member

      Location:
      Germany
      Tinnitus Since:
      02/2016
      Cause of Tinnitus:
      unknown
      Ok I decided to go the medication route but not trobalt since side effect seems to be persistent .
      I will try to get this stuff pramipexole
       
      • Like Like x 1
    7. Rubenslash

      Rubenslash Member

      Location:
      Brussels
      Tinnitus Since:
      04/2016
      Cause of Tinnitus:
      Several
      Please keep us posted
       
    8. Pleasure_Paulie

      Pleasure_Paulie Member

      Location:
      Australia
      Tinnitus Since:
      06/2016
      Cause of Tinnitus:
      Noise or maybe... unicorns!
      I might ask my Psychiatrist for a prescription of this as well. Lyrica isn't really helping me as much at I had hoped and probably giving me headaches.
       
    9. Tigo

      Tigo Member

      Tinnitus Since:
      2 years
      Cause of Tinnitus:
      genetic hearing loss
      Is there anybody currently taking pramipexole ? Is it working ?
       
    10. Pleasure_Paulie

      Pleasure_Paulie Member

      Location:
      Australia
      Tinnitus Since:
      06/2016
      Cause of Tinnitus:
      Noise or maybe... unicorns!
      I'm currently trying memantine, but will be tying this after with my doctor.
       
    11. MikeGreen
      Uninvolved

      MikeGreen Member

      Tinnitus Since:
      2016
      Cause of Tinnitus:
      Spotify
      Hello, are these recent promising drugs able to supress Tinnitus? Or heal it?
       
    12. Pleasure_Paulie

      Pleasure_Paulie Member

      Location:
      Australia
      Tinnitus Since:
      06/2016
      Cause of Tinnitus:
      Noise or maybe... unicorns!
      They may/may not work and if they do it will result in a reduction in your tinnitus intensity.
       
    13. Pleasure_Paulie

      Pleasure_Paulie Member

      Location:
      Australia
      Tinnitus Since:
      06/2016
      Cause of Tinnitus:
      Noise or maybe... unicorns!
      I just started on Sifrol ER so will report back if this drug helps me :)
       
      • Like Like x 1
    14. Jim51042

      Jim51042 Member

      Tinnitus Since:
      3/28/16
      Cause of Tinnitus:
      Headphone use
      Cool thanks
       
    15. Pleasure_Paulie

      Pleasure_Paulie Member

      Location:
      Australia
      Tinnitus Since:
      06/2016
      Cause of Tinnitus:
      Noise or maybe... unicorns!
      I've been on .375mg Sifrol ER (Extended release) for about a week now, I can't say its done much for my T but that's also considered quite a low dosage (Im 90kg too) so I need to titrate my dosage up over the coming weeks to give a definite yes/no.

      Side effects: Nausea the next day after taking it (I take before bed), some tiredness and restlessness when I initially started for the first few days. I believe its lowered my libido as well - interesting as many people report the opposite on this drug. The side effects are very tolerable so far though.
       
    16. Mic
      Buzzed

      Mic Member

      Tinnitus Since:
      -
      Recently I started a personal research project for rare cases in which Tinnitus diminished/lowered due to use of meds for other conditions. One of the cases I found is connected with the use of pramipexole for Parkinson: http://forum.parkinson.org/topic/20783-tinnitus/#comment-110292

      I mailed this user for more information. She responded with a detailed description of her experience:

      "When I was first diagnosed in July of 2015, my neurologist prescribed two dopamine agonists (DA's), the Neupro transdermal patch and pramipexole tablets (generic for Mirapex). About a year later, I started seeing a specialist (MDS), who weaned me off pramipexole due to falling asleep while driving. I've noticed that since going to only one DA that I do experience tinnitus on rare occasion, but it isn't nearly as severe, lengthy, or frequent as it had once been. It was only because it happened one day after months of absence that I even realized it had subsided.
      Description of the tinnitus: high pitched w/o hearing loss. I'm not quite sure, but I think location would vary, as well as the volume. Sometimes it was in one ear or the other, sometimes both. No matter the location, the volume would often fluctuate (and was often asymmetrical when it was bilateral), especially as my overall condition worsened. Prior to diagnosis, I thought my infrequent tinnitus was due to chronic allergic rhinitis.

      I prefer the patch to the tablets because I think the effect is more dramatic; the first time I forgot a patch, it was obvious. The pills, not so much. Besides, I already take several pills; plus, there's less fluctuation in symptoms with the patch.

      Despite the side effect of wicked nausea that eventually subsides (I lost 10 lbs the first month) and the high cost (the manufacturer website has a patient assistance program to help make it affordable), I love the Neupro patch."

      So... this could be good news or it could be a one time lucky coincidence...
      My advice is to consult your doctor before attempting any experiment on yourself.

      Lastly I also can share that I have found two other cases of diminishing tinnitus that could be connected with the use of a combination of dopamine, serotonin and benzo meds.

      If this leads to something worth to share you will hear from me.
       
      • Like Like x 2
    17. jacob21
      Amazed

      jacob21 Member Benefactor

      Tinnitus Since:
      2008 > 2009 "cured" >2nd onset June 2016
      Cause of Tinnitus:
      Noise Induce ( loud music )
      is this drug have bad side effects?

      How many people tried it? if yes do we have some update?

      @Pleasure_Paulie please keep us updated . Hope you ll find some relief .

      Jacob
       
    18. Tigo

      Tigo Member

      Tinnitus Since:
      2 years
      Cause of Tinnitus:
      genetic hearing loss
      Pramipexole shut downs my T for 7 days then it came back. No side affects!
       
    19. meeb
      Sad

      meeb Member

      Tinnitus Since:
      2002
      Cause of Tinnitus:
      loud clubs initially, now louder due to noise & vibrations.
      I am desperate, depressed and not rich, I may just make an appointment at the doctors and attempt to get a prescription for this. I will let you know what happens.
       
    20. Kekistan

      Kekistan Member

      Tinnitus Since:
      03/2017
      Cause of Tinnitus:
      Unknown
      Did it help?
       
      • Friendly Friendly x 1
    21. Pleasure_Paulie

      Pleasure_Paulie Member

      Location:
      Australia
      Tinnitus Since:
      06/2016
      Cause of Tinnitus:
      Noise or maybe... unicorns!
      I'm still on Pramipexole .375mg extended release, daily. I missed a dosage last night by accident and you notice straight away - you feel very "thick" and feel slow in the head so you would need to taper when coming off this drug.

      I'm planning to up my dosage this coming week since most of the nausea has ceased. The drug can make getting to sleep difficult as it makes you tired, but restless so you end up tired but can't sleep lol. I don't think I've noticed much real reduction in T volume (but still on a low dosage) but I believe the drug may have some anti depressant properties so sometimes you feel better about the whole situation of having Tinnitus. The side effects are tolerable and it seems quite safe so far, but it doesn't feel like a silver bullet drug as far as assistance with Tinnitus so far!
       
      • Like Like x 1
    22. grate_biff
      Alone

      grate_biff Member Benefactor

      Location:
      Oslo, Norway
      Tinnitus Since:
      09/2014
      Cause of Tinnitus:
      Acoustic trauma, benzo/mirtazapine withdrawal, or combo!
      You mean it came back, while still on the medication?
       
    23. Tigo

      Tigo Member

      Tinnitus Since:
      2 years
      Cause of Tinnitus:
      genetic hearing loss
      Yes grate_biff
       
    24. grate_biff
      Alone

      grate_biff Member Benefactor

      Location:
      Oslo, Norway
      Tinnitus Since:
      09/2014
      Cause of Tinnitus:
      Acoustic trauma, benzo/mirtazapine withdrawal, or combo!
      Hmm.. Got it prescribed today, so may as well try it for myself.
      Starting with one 0,088mg before bed today.
       
    25. Tigo

      Tigo Member

      Tinnitus Since:
      2 years
      Cause of Tinnitus:
      genetic hearing loss
      It will take a week before noticing any effect! Keep us updated great_biff
       
    26. grate_biff
      Alone

      grate_biff Member Benefactor

      Location:
      Oslo, Norway
      Tinnitus Since:
      09/2014
      Cause of Tinnitus:
      Acoustic trauma, benzo/mirtazapine withdrawal, or combo!
      I will
       
    27. Pleasure_Paulie

      Pleasure_Paulie Member

      Location:
      Australia
      Tinnitus Since:
      06/2016
      Cause of Tinnitus:
      Noise or maybe... unicorns!
      Did the Doc give you the Extended release version like I'm taking?
       
    28. grate_biff
      Alone

      grate_biff Member Benefactor

      Location:
      Oslo, Norway
      Tinnitus Since:
      09/2014
      Cause of Tinnitus:
      Acoustic trauma, benzo/mirtazapine withdrawal, or combo!
      No, just the regular one to begin with.
       
    29. meeb
      Sad

      meeb Member

      Tinnitus Since:
      2002
      Cause of Tinnitus:
      loud clubs initially, now louder due to noise & vibrations.
      I have to try and get it first :D
       
    30. Mic
      Buzzed

      Mic Member

      Tinnitus Since:
      -
      On another forum there is a case in which pramipexole diminished/lowered the tinnitus of somebody effectively.

      The summary of the case is:
      • The dosage the man used was 1-.25mg pill 3x / day
      • He also used Amitriptyline as a med next to pramipexole (this combination of meds could also be important for his experience)
      • The effect seemed to wear off after some time but let him experience real silence (ohhh that would be great...) a couple of times in the beginning (he had lived for 12 years with tinnitus till then)
      Hope this helps some of you.
       
      • Friendly Friendly x 1

Share This Page

Loading...