Tinnitus Control by Dopamine Agonist Pramipexole in Presbycusis Patients

Discussion in 'Research News' started by rogerg, Mar 30, 2011.

    1. Pleasure_Paulie

      Pleasure_Paulie Member

      Location:
      Australia
      Tinnitus Since:
      06/2016
      Cause of Tinnitus:
      Noise or maybe... unicorns!
      That is a very high dosage of pramipexole, but funny enough I plan to ask my doc for Amitriptyline as the next drug to try. I just started .75 extended release. They would also probably work together quite well as far as sleep. One of the side effects of pramipexole is that is can make you restless and sleeping can be troublesome.
       
    2. meeb
      Sad

      meeb Member

      Tinnitus Since:
      2002
      Cause of Tinnitus:
      loud clubs initially, now louder due to noise & vibrations.
      GP said that it isn't available for prescription in The United Kingdom.
       
    3. Pleasure_Paulie

      Pleasure_Paulie Member

      Location:
      Australia
      Tinnitus Since:
      06/2016
      Cause of Tinnitus:
      Noise or maybe... unicorns!
      Update:

      I'm still taking Pramipexole extended release (1 tablet a day). The drug seems to make you more hungry, but most side effects have most subsided now except when I try and up my dosage. These types of medication medication drugs can at times have an unexpected side effect of increased libido and I have noticed this on occasion too.

      I don't know if the medication has given me a noticeable increase in volume, but at times it has helped me not notice the noise as much. I'm going to keep taking this med as the side effects are very minimal, and try to play around with dosages more.
       
      • Informative Informative x 1
    4. grate_biff
      Alone

      grate_biff Member Benefactor

      Location:
      Oslo, Norway
      Tinnitus Since:
      09/2014
      Cause of Tinnitus:
      Acoustic trauma, benzo/mirtazapine withdrawal, or combo!
      I have stopped my trial bc i decided to try Lamotrigine and my GP didnt want me to take both. A bit unfortunate I agree, but I have other pressing problems besides T that I need to adress.( a glutumatergic- and Gaba system out of whack) I reached only 0,088 mg TID. I felt like it had a slight improvement on T, especially in the morning, but would soon reach normal level. I also felt the nausea problematic, but I was already nauseas before starting, so dont know if I can really blame the drug. It does exactly the opposite of the only drug that help me with my nausea, so there is that.
      I will follow you @Pleasure_Paulie with interest. Hopefully it will do wonders for you;)
       
    5. Pleasure_Paulie

      Pleasure_Paulie Member

      Location:
      Australia
      Tinnitus Since:
      06/2016
      Cause of Tinnitus:
      Noise or maybe... unicorns!
      So I'm on .75mg extended release of this now. I think the medication has "thinned" out my Tinnitus. It's certainly still there, but makes it feel more in your background and less intrusive.

      I will continue this drug and maybe even continue to increase my dosage (.75mg is still very low). The side effects are very mild once the first few weeks of nausea are gone and the increased sex drive is always welcome! :)
       
      • Informative Informative x 2
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    6. jacob21
      Amazed

      jacob21 Member Benefactor

      Tinnitus Since:
      2008 > 2009 "cured" >2nd onset June 2016
      Cause of Tinnitus:
      Noise Induce ( loud music )
    7. Pleasure_Paulie

      Pleasure_Paulie Member

      Location:
      Australia
      Tinnitus Since:
      06/2016
      Cause of Tinnitus:
      Noise or maybe... unicorns!
      I have very mild hearing loss and have done a hearing test up to 12,000hz :)
       
    8. jacob21
      Amazed

      jacob21 Member Benefactor

      Tinnitus Since:
      2008 > 2009 "cured" >2nd onset June 2016
      Cause of Tinnitus:
      Noise Induce ( loud music )
    9. Pleasure_Paulie

      Pleasure_Paulie Member

      Location:
      Australia
      Tinnitus Since:
      06/2016
      Cause of Tinnitus:
      Noise or maybe... unicorns!
      My shrink said some people take this drug for years without any issues. Again, I think it just takes an edge off the Tinnitus intensity for me but I will see if higher dosages bring real volume reduction. I don't believe it would ever bring the complete silence people seemed to get on Trobalt - but this drug has almost no side effects for me as well!
       
    10. Tigo

      Tigo Member

      Tinnitus Since:
      2 years
      Cause of Tinnitus:
      genetic hearing loss
      A couple of months ago i was also on Prami. No side effects and a reduction of my T. It was if i was in heaven. It last for whole week then my T came back. After that i stopped !
      This week i start again! Fingers crossed.
       
      • Helpful Helpful x 1
      • Useful Useful x 1
    11. jacob21
      Amazed

      jacob21 Member Benefactor

      Tinnitus Since:
      2008 > 2009 "cured" >2nd onset June 2016
      Cause of Tinnitus:
      Noise Induce ( loud music )
      @Tigo : Great !

      which dose ? DId you have side effects ?
       
    12. Tigo

      Tigo Member

      Tinnitus Since:
      2 years
      Cause of Tinnitus:
      genetic hearing loss
      Doses as recommended for the parkison desease!
      Side effects: Happy and more energy
       
    13. jacob21
      Amazed

      jacob21 Member Benefactor

      Tinnitus Since:
      2008 > 2009 "cured" >2nd onset June 2016
      Cause of Tinnitus:
      Noise Induce ( loud music )
      whoua ! :)

      Question , sorry to bother :
      how long it take to reduce the level of your T.
      Is it something we could use as a painkiller only the day we have spike ?
       
    14. Tigo

      Tigo Member

      Tinnitus Since:
      2 years
      Cause of Tinnitus:
      genetic hearing loss
      For me it takes a week to notice effect. The dopamine has to build up in your brain!
       
    15. Pleasure_Paulie

      Pleasure_Paulie Member

      Location:
      Australia
      Tinnitus Since:
      06/2016
      Cause of Tinnitus:
      Noise or maybe... unicorns!
      No. The medication takes 1-2 weeks before you notice any effect. Stick to Benzodiazepines if you want to use on an ad hoc basis :)
       
    16. Pleasure_Paulie

      Pleasure_Paulie Member

      Location:
      Australia
      Tinnitus Since:
      06/2016
      Cause of Tinnitus:
      Noise or maybe... unicorns!
      What dosage is that as the max dosage is 4.5mg a day - is that what you're on?
       
    17. Tigo

      Tigo Member

      Tinnitus Since:
      2 years
      Cause of Tinnitus:
      genetic hearing loss
      0,088 Mg 6 times a day
       
    18. Pleasure_Paulie

      Pleasure_Paulie Member

      Location:
      Australia
      Tinnitus Since:
      06/2016
      Cause of Tinnitus:
      Noise or maybe... unicorns!
      That's huge ha!
       
    19. Jim51042

      Jim51042 Member

      Tinnitus Since:
      3/28/16
      Cause of Tinnitus:
      Headphone use
      I think he is using the comma as a decimal. They do that in Europe. So I think he means 88 micrograms 6 times a day or .53 milligrams per day
       
      • Helpful Helpful x 1
    20. Tigo

      Tigo Member

      Tinnitus Since:
      2 years
      Cause of Tinnitus:
      genetic hearing loss
      Thats correct jim51042
      Whats the max dose that you can take? I dont know!
       
    21. Pleasure_Paulie

      Pleasure_Paulie Member

      Location:
      Australia
      Tinnitus Since:
      06/2016
      Cause of Tinnitus:
      Noise or maybe... unicorns!
      Max is 4.5mg a day either in single tablets spread over the day or extended release tablet like I'm on.
       
    22. Mic
      Buzzed

      Mic Member

      Tinnitus Since:
      -
      A month ago I posted the message below about the correspondence I had with a Parkinson patient with subsidising tinnitus after the use of meds for her condition.

      In my reply I asked for more and specific information. Her reply was as follows:

      "I'm sorry for not getting back to you sooner; you know how busy life can be. Yes, of course, you may share my response with the community. I'm happy to help if possible.

      Your interpretation is correct: my tinnitus was never 24/7, not even close. When I was on Pramipexole AND Neupro, it was virtually nonexistent. After weaning off Pramipexole, I noticed it occasionally. I've noticed it a little more lately, which I think may have something to do with the fact that, for some reason, I have sometimes been forgetting to change it near the 24 hour mark. On these occasions, it’s usually about 36 hours between patches.

      I'm not sure if the other medications I'm taking (Rytary 23.75mg/95mg, Amantadine 100mg, Selegiline 5 mg) have an effect on tinnitus, but I'm inclined to think not. I definitely think Neupro should be looked at as a possible drug therapy and perhaps others in the dopamine agonist class as well.

      I hope my answers are insightful. Keep me posted on any new developments or research. Best of luck to you & the others!"

      So... the fact she hadn't got tinnitus 24/7 is not pledging for evidence that Pramipexole is effective at the endpoint triggers in the brain of tinnitus perception but in the treatment of another condition in the chain of causality that leads to tinnitus.

      More likely (and I hope this is the case) Pramipexole is still weakly influencing the endpoint trigger for tinnitus but in itself it isn't effective as a compound to give relief at the safe dosing levels (this is common in meds as they are effecting multiple chemical processes in the body... this is why you also have side effects).
       
    23. Pleasure_Paulie

      Pleasure_Paulie Member

      Location:
      Australia
      Tinnitus Since:
      06/2016
      Cause of Tinnitus:
      Noise or maybe... unicorns!
      Thank you. Unfortunately I believe she is on too many medications to really prove the effectiveness of pramipexole either way.
       
    24. Michael Larsen
      Surfing

      Michael Larsen Member

      Tinnitus Since:
      2000
      Cause of Tinnitus:
      Noice
      where is the best place to buy Pra. (a safe place)
       
    25. Pleasure_Paulie

      Pleasure_Paulie Member

      Location:
      Australia
      Tinnitus Since:
      06/2016
      Cause of Tinnitus:
      Noise or maybe... unicorns!
      Your doctor :) Find one that will give you a prescription. Don't buy the Indian garbage.
       
    26. Michael Larsen
      Surfing

      Michael Larsen Member

      Tinnitus Since:
      2000
      Cause of Tinnitus:
      Noice
      Thank you, I will try to do that.
       
    27. Kekistan

      Kekistan Member

      Tinnitus Since:
      03/2017
      Cause of Tinnitus:
      Unknown
      So
      so is it worth a try?
       
    28. Pleasure_Paulie

      Pleasure_Paulie Member

      Location:
      Australia
      Tinnitus Since:
      06/2016
      Cause of Tinnitus:
      Noise or maybe... unicorns!
      I'm only on .75mg extended release. I don't think it's going to give you silence people reported on Trobalt, but it may sometimes make Tinnitus feel more in the background and thin the sound out. The side effects are hard the first week, than acceptable after that.
       
    29. Pleasure_Paulie

      Pleasure_Paulie Member

      Location:
      Australia
      Tinnitus Since:
      06/2016
      Cause of Tinnitus:
      Noise or maybe... unicorns!
      @Fabrikat @grate_biff
      The drug gives you a better mood, has positive sexual side effects, helped me at the gym gain more muscle, and may have reduced my tinnitus volume by around 5%. I went back to my very low dosage of .375mg extended release.
       
    30. Fabrikat

      Fabrikat Member

      Tinnitus Since:
      1973
      Cause of Tinnitus:
      Otosclerosis then volume then viral infection
      Will you keep taking this drug for the foreseeable future? And if so, will you continue to take it for tinnitus or for all the other benefits?
       

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