Tinnitus Research Initiative / Annual TRI Conferences

[Markku]

Out of curiosity, I've spent many hours reading TRI's PDFs, which are very informative.

A few links for those who are interested in tinnitus research and what kind of studies/results are being carried out:

http://www.tinnitusresearch.org/en/meetings/meeting2010_en.php
(check: http://www.tinnitusresearch.org/en/meetings/files2010/abstractbook_Dallas_2010.pdf - which includes the abstract book for their 2010 meeting in Dallas)

And the TRI's newsletters are worth a read too: http://www.tinnitusresearch.org/en/news/news_en.php

They include all the latest recently published literature and case studies and such. Indeed worth a read.

 

[Michelle78]

Having always been a science "freak" I will take a look. If anything I'm happy there are initiatives like TRI.

 

[Mukul Kumar Sharma]

Hey this is good stuff... Thanks admin!

 

[Markku]

2011 meeting was held in Buffalo, NY/US: http://www.tinnitusresearch.org/en/meetings/meeting2011_en.php

Actually I haven't looked into this yet (I'm late I know), but it's going to be a good read, the abstract book I mean: http://www.tinnitusresearch.org/en/meetings/files2011/5th TRI Conference ABSTRACTS.pdf

Tinnitus: Pharmacological Intervention, What Should We Target?
Ana Belén Elgoyhen
Instituto de Investigaciones en Ingeniería Genética, CONICET. Buenos Aires, Argentina
One in 10 adults has clinically significant subjective tinnitus, and for 1 in 100, tinnitus severely affects their quality of life. Despite the significant unmet clinical need for a safe and effective drug targeting tinnitus relief, there is currently not a single FDA-approved drug on the market. Since in some individuals, tinnitus causes irritability, agitation, stress, depression, insomnia and interferes with normal life, even a drug that produces a small but significant effect would have a huge therapeutic impact. The search for drugs that target tinnitus is hampered by the lack of a deep knowledge of the underlying neural substrates of this pathology. Initially considered an inner ear pathology, it is now clear that at least chronic tinnitus is a central nervous system disorder. Based on recent progress in the understanding of tinnitus, I will focus my talk on a brief overview of the pharmacotherapies that have been used, on the challenges faced when designing a tinnitus pharmacotherapy, on potential neural substrates as targets for pharmacological intervention and on the approach followed by the TRI Pharma Workgroup.

So basically these are just what it says on the tin: abstracts.

TRI has tons of good newsletters too, with more detailed conclusions of studies etc. If you are interested in such stuff, check these (especially the newsletters):
Recent TRI related publications: http://www.tinnitusresearch.org/TRI_related_publications.pdf
TRI Newsletters: http://www.tinnitusresearch.org/en/news/news_en.php


Next year their meeting will be in Belgium.

 

[Markku]

Research Projects 2010/2011 on Tinnitus / Vertigo / Hearing Loss

 

[joe]

Who do you think is going to bring out the first proper treatment that's going to work for Tinnitus?

 

[Markku]

I'd rather not guess.

It depends on the definition of working treatment. I think it's a long shot we'll see a treatment that completely silences the majority of tinnitus in the near future. Near future meaning within the next 5 years.

It's far more likely that there will be some treatments that may reduce the intensity of tinnitus, for example. Many people would kill for a 50% reduction.

Who knows, the Vagus Nerve Stimulation looked somewhat promising when it made news the beginning of last year. Although it was based on tests with rats, so needs further studies. Vagus Nerve Stimulation Helps Resolve Tinnitus in Rats

There are some pharmaceuticals that might help some people. Neramexane is being researched and tested. Neramexane Clinical Study

Even though I would like to get rid of my tinnitus completely, I'm not really holding my breath for that. I'd be so, so happy for a treatment that made my ringing and clicking less intense. I guess many people would settle for the same at least until better and more effective treatments came along.

 

[joe]

Yes, I would agree, I got my money on Vagus Nerve Stimulation, I think Neramexane trial will be suspended soon.

 

[Markku]

Yes, I would agree, I got my money on Vagus Nerve Stimulation, I think Neramexane trial will be suspended soon.

Neramexane is in Phase III though. So it's not just starting the trials.

If Phase III results are positive and nothing surprising happens, it's possible Neramexane could come into market (indicated for tinnitus).

But I haven't found one single positive experience of Neramexane for tinnitus on the internet. Okay, I have only seen like 5 people mention that they are in the Neramexane trial, and of course they weren't sure whether they are getting the placebo or the real deal. But none of those that I remember did notice any effect on their tinnitus.

 

[joe]

http://www.aerztezeitung.de/praxis_...-steckt-neramexane-schlappe-gelassen-weg.html
Its failed, and its cost Merz Pharma Millions, the company has taken a huge financial blow, Its sad and disappointing for all us sufferers. This will now be talk in the Pharma Industry, and other Pharma's are going to think twice about investing into Tinnitus now But lets hope Quark, and Sound Pharma keep going as they are now the only hope !!! Auris's Medical AM 101 treatment is only effective if their drug is administered within a 3 month window of Tinnitus, " And thats not going to help us old timers Damm !!! Markku I am keeping my Money On Vagus Nerve for Now, unless you have any other news of any other Drug coming out Shortly? Over to you my Friend, I am going to go and put my head in the SAND

 

[Markku]

http://www.aerztezeitung.de/praxis_...-steckt-neramexane-schlappe-gelassen-weg.html
Its failed, and its cost Merz Pharma Millions, the company has taken a huge financial blow, Its sad and disappointing for all us sufferers. This will now be talk in the Pharma Industry, and other Pharma's are going to think twice about investing into Tinnitus now But lets hope Quark, and Sound Pharma keep going as they are now the only hope !!! Auris's Medical AM 101 treatment is only effective if their drug is administered within a 3 month window of Tinnitus, " And thats not going to help us old timers Damm !!! Markku I am keeping my Money On Vagus Nerve for Now, unless you have any other news of any other Drug coming out Shortly? Over to you my Friend, I am going to go and put my head in the SAND

Oh shoot...

First time I heard about this.

Google translated quote from that article:

"Several reasons for the failure of phase III trials
According to the reins, there are several reasons for the failure of previous attempts. Thus, all three study arms with an average of 300 patients were probably occupied too low.
In addition, we have underestimated the high placebo effect, which amounts to about 40 percent of the tinnitus, which hinders the efficacy significantly.
Another reason for the unsatisfactory results is the subjective factor, which correlates with the severity of the disease. There were patients that tinnitus did not perceive as a nuisance and such, so reins, "prefer to jump out the window would be."
A set of tools to filter out those patients specifically have been missing. Reins: "We must be in a better diagnosis." That would account for the present test by Kyorin."

Thanks for letting me know, now we can cross Neramexane off the list.

 

[joe]

Ok, So whats the next Drug in the pipeline?????

 

[Markku]

Ok, So whats the next Drug in the pipeline?????

No idea... for the not-so-recent cases, I don't know if there's anything interesting in the pipeline.

Regarding AM-101 I last year wrote this;

As always, I'm very much looking forward to the results from the trials. So far it's not really 100% certain how long the window of administration is after the onset of tinnitus. The trials exclude people who have had tinnitus for longer than 3 months, but it doesn't necessarily mean the drug won't work for tinnitus cases that are, say, 6 months old. But if the brain maps in the somatosensory and auditory cortex have already changed, then this might not work.

 

[Karl]

My audiologist sent me the following program for the 6th International TRI Conference on Tinnitus 2012, held in Bruges, Belgium, June 13-16, 2012:

http://www.tinnitusresearch.org/en/news/pdfs/TRI Newsletter 2112.pdf

 

[mock turtle]

Karl

a treasure trove of information

im just going thru it now and checking out what links i can find from the list of authors and research papers

great stuff
i especially find this fascinating

"Pienkowski M, Eggermont JJ. Reversible long-term changes in auditory processing in mature auditory cortex in the absence of hearing loss induced by passive, moderate-level sound exposure. Ear Hear. 2012 May;33(3):305-14.
By demonstrating that cortical reorganization can be caused by moderate band pass filtered noise without causing any peripheral damage, the authors provide an explanation for tinnitus and auditory processing disorders with intact peripheral auditory function."


thanks for the information!
mt

 

[erik]

Video
Openings Speaker Rik Torfs

Keynote Speaker Nathan Weisz

Keynote Speaker Roland Schaette (research grant by the British Tinnitus Association)

Keynote Speaker Pawel Jastreboff

 

[click]

Hi Erik - having real trouble with understanding the accent (Jastreboff video) - do you know if there is a transcript anywhere? Thanks. Click

 

[erik]

Sorry Click, I am not aware of a transcript

 

[jazz]

Hi all,

I don't know if someone has already posted this link, but I just found the most recent (looks like Dec. 2012) newsletter from the TRI. Lots of good stuff!!

http://www.tinnitusresearch.org/en/news/pdfs/TRI Newsletter 2312.pdf

 

[daedalus]

Forgot to post this here. The 7th TRI conference on tinnitus happens in may this year (2013). As always there will be top notch researchers. Familiar names and a few new ones. You can find the complete program here: http://www.tinnitusresearch.org/en/meetings/files2013/TRI2013_scientific_program.pdf

I found this particularly eye catching:

Towards an objectivation of tinnitus.
Machine learning approach of resting state electrical
brain activity can detect the presence of tinnitus by K Joos

 

[Hudson]

It would be nice to hear of some moving research at this years TRI conference happening this week. I know of a researcher (grad student) who will be in attendance at this years conference in Spain. He said that he would be posting some information about what research he finds particularly interesting and moving on the Tinnitus subreddit that he follows. Perhaps he'll be posting there in about a week, you guys can check it out.

www.reddit.com/r/tinnitus

 

[Hudson]

I think the TRI conference is underway in Valencia, Spain ATM. It would be very interesting to hear some of the speakers. The opening speech "To Dream is to Cure Tinnitus" is being put on by Dr. Ridder. I wonder if they will have any transcripts or other information posted online? I doubt there's going to be any minute to minute coverage, but considering this conference is the cadillac of Tinnitus research conferences, I bet there will be a lot of previously unreleased research results, insights, opinions and prognostications about research direction. Post up in here if you guys find anything over the next few days!

 

[Louise]

The opening speech "To Dream is to Cure Tinnitus"

The "dream"?, "dream"? I had hoped they felt a bit closer than that

 

[dan]

#$%@ing dream.

 

[michalCZ]

Adding abstracts of the 6th International Conference on TRI tinnitus. There is more information than in the program (see above).
I know that currently takes place 7th International Conference on TRI Tinnitus, but I registered here until today.

 

[michalCZ]

The 6th last year I found somewhere on the web abstracts and gave it to another topic. So I hope someone will find it somewhere ( from 7th ).
On the 7th of this year I have only this link:
tri2013.tinnitusresearch.org

 

[Hudson]

The 2013 abstract pdf is up folks. Happy reading!


http://tinnitusresearch.org/en/meetings/files2013/TRI2013_program_book.pdf

 

[Hudson]

I was hoping to have a look at AM-101's results from their trial that they recently completed (within the last month) but at the TRI conference (and on their website for that matter) they posted only the safety aspects of the trial. They go on to state efficacy results will be posted in a scientific journal later this summer.

This is all supposition, but I'm assuming that the results from that trial will be decent to good anyway, otherwise they would not have recently secured as much funding from a private equity organization like they did. Nobody bets their cookies on a crappy deal, at least no one wise does.

 

[michalCZ]

The 2013 abstract pdf is up folks. Happy reading!


http://tinnitusresearch.org/en/meetings/files2013/TRI2013_program_book.pdf

Cool, that was fast ! Thanks.

 

[Hudson]

I thought that the paper about AUT3, a KV3 channel modulator was pretty cool. It looks like Autifony Theraputics was in on it as well, and that seems to fit in nicely with their drug development strategy as stated on their website. Perhaps they have a somewhat promising drug in the pipeline, but I'm sure it will take some time to get to clinical trials if it does.