@lapidus posted:
Dr. Nagler what is your take on this?
Is [trihexyphenidyl] something you have to get prescribed by a doctor?
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Yes.
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Since it's for parkinsons I really can't see how one could get a doctor to prescribe [trihexyphenidyl] for another issue [like hyperacusis or tinnitus].
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It is called prescribing for "off-label use" and is actually a rather common practice. For instance, back in 2005 the biggest craze in tinnitus treatment was Campral (acamprosate), a drug approved for use in the treatment of alcoholism. What happened was that a couple of investigators from Brazil published a really terrible study showing acamprosate to be 87% effective in providing significant relief in the treatment of tinnitus. Word spread across the tinnitus community like wildfire (through support boards), and everybody was asking physicians for prescriptions based on the study. So thousands of prescriptions for off-label use of acamprosate were written. (Subsequently the flaws in the Brazilian study became evident, and a meticulous reliable conclusive study done by respected investigators at the Oregon Health and Science University in Portland showed acamprosate to be no more effective in the treatment of tinnitus than placebo.)
Having been there myself, I can readily understand how in their desperation, tinnitus sufferers will willingly grasp at anything in search of relief. But please trust me on this: When a treatment (acamprosate, lipoflavinoids, ginkgo, LLLT, acupuncture, whatever) is found to reliably mitigate the tinnitus signal in a statistically significant percentage of the tinnitus population, everybody will know about it.
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And also, I think that H just like T is a very complex disorder, and one thing that works for someone will probably not work for everyone. Some people have been completely cured with xanax following this protocol http://www.chat-hyperacusis.net/post/jack-vernon-and-hyperacusis-xanax-protocol-5929777 while it had little to no effect on others.
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Well, if you go to the above link and read through the thread, you will see reference to a "member deleted" who was a close friend of Dr. Jack Vernon. I am that close friend of Dr. Vernon's. But Xanax does not cure anybody with hyperacusis! Dr. Vernon, ever the optimist, noticed that a handful of folks showed improvement and spoke about it. But the effect was no greater than placebo. Just because a person shows improvement after taking drug A, that doesn't mean that the improvement was
caused by drug A. Same with Xanax and tinnitus, by the way. Xanax is probably the most common drug prescribed for tinnitus; however, the
1993 Johnson, Brummett, and Schleuning study that stimulated all the interest was poorly controlled, and the findings were never duplicated. Any effects of Xanax on tinnitus are achieved by decreasing anxiety (which is what Xanax does) and not by mitigating the tinnitus signal itself.
Hope this helps more than confuses.
Stephen Nagler