Paulmanlike

Too much earplugging?

No tried to remove was the safe way. Build up of wax. Moisture. Probably caused build up of bacteria.

Do you mean ibuprofen? I think with ibuprofen it is usually temporary. Switch to acetaminophen and start with lowest dose, lower if you can. I am not a doctor.

Yes. Extended use can be permanent and also hearing loss. Not too worried and its pretty much gone. Obviously the established T rings away still.

Ah yes. It seems almost any medication I take affects mine now. I usually don’t take anything for headaches until it becomes unbearable. I used to eat ibuprofen like candy.

Just kidding! Unless...

Xenons reformulations of Retigabine, especially XEN1101; Ebselen and OTO-313

FX322

would be awesome but everything for tinnitus or hearing loss is acute only at the moment, would be a damn shame if it ended up working for acute cases only because we would all be so fucked.

I know, I feel like I got kicked in the nuts. I think the takeaway from this is additional doses were worse in weekly succession and next time they should try monthly. They did another Phase 1b trial that showed that a single dose of FX-322 was effective, so that’s two Phase 1b trial that shows the single dose was effective. We still have age-related and severe hearing loss trial left.

I have a feeling the age-related hearing loss will be positive but I’m unsure about the severe category as the drug needs to go deeper in the round window.

I think it means that you either post a lot or have got a lot of ratings from people.

Same, I hope FX-322 has no problem reaching deeper in the round window with additional doses to be more effective and get rid of tinnitus and hyperacusis.

I can’t wait, I hope it’s good news.

I have a good feeling.

Same man. It is such a long wait but going through this I hope it was worth it and FX-322 will cure us.

I hope it helps my terrible hearing and rids me of this ringing.

This will be a pivotal year for so many.

And willingly gave an hour of interview time to a specifically tinnitus-themed podcast.

Did you mean 500 years

No

Not at all

Any spikes after ear irrigations?

None. There never is for me anyway.

Havent managed to get it done yet. I usually opt for irrigation as suctioning was hugely uncomfortable for me. It blocks occasionally. Praying it eases the tinnitus.

What about manual removal?

I've never had a problem irrigation and I've done it about 6 times. Fully blocked again this morning, cant hear shit!!

Do you use earplugs a lot? Possible reason?

Never. Just make lots of it and its affecting my hearing now.

It's not private you've wrote on my wall. You can directly inbox me if you wish. I was just curious to know how much people would invest in a company like Freq.

The concept of diversification implies that people with T Shouldn't invest into FX Therapeutics.

I agree Bill Bauer. The whole investment in T treatments, from an objective view, is incredibly high risk. Emotional investment clouds judgements. If you can take a sucker punch if it fails then go ahead.

There's a whole thread about it here:

https://www.tinnitustalk.com/threads/flare-audio-calmer-%E2%80%94-does-it-help-tinnitus.41689/

Thanks @Markku will check it out