Neramexane for Tinnitus

To assess the safety and efficacy of Neramexane compared with placebo.

  1. Tinnitus Talk
    Tinnitus is commonly referred to as "ringing of the ears" - the perception of sounds in the absence of an external source of acoustic signals. Tinnitus may represent a severe disease and symptoms include depression, sleeping difficulties, decreased sound tolerance and hearing loss. One hypothesis is that tinnitus is caused by an increased activity of NMDA glutamate and dysfunctional alpha9/alpha10 acetylcholine receptors in the inner ear and central nervous system. Neramexane may alleviate tinnitus symptoms due to its NMDA and alpha9/alpha10 nACh receptor blocking activity. The purpose of this study is to assess the safety and efficacy of Neramexane compared with placebo in patients with subjective tinnitus.


    Enrollment: 431
    Study Start Date: October 2005
    Study Completion Date: March 2007
    Primary Completion Date: March 2007 (Final data collection date for primary outcome measure)
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