Neramexane for Tinnitus

[Tinnitus Talk]

Tinnitus Talk submitted a new resource:

Neramexane for Tinnitus (version 1.0) - To assess the safety and efficacy of Neramexane compared with placebo.

Tinnitus is commonly referred to as "ringing of the ears" - the perception of sounds in the absence of an external source of acoustic signals. Tinnitus may represent a severe disease and symptoms include depression, sleeping difficulties, decreased sound tolerance and hearing loss. One hypothesis is that tinnitus is caused by an increased activity of NMDA glutamate and dysfunctional alpha9/alpha10 acetylcholine receptors in the inner ear and central nervous system. Neramexane may alleviate...

Read more about this resource...

 

[Hudson]

http://www.biomedcentral.com/1472-6815/11/1

I remember that everyone in the forums had utterly given up on this. The results point to some improvement which may warrant further studies. Who knows.

 

[jazz]

Another drug (probably) bites the dust....

From their website, Merz notes it is no longer actively involved in Neramexane, but is still functioning in a supportive role. I believe this pertains to a "clinical study" with a drug partner in Japan:

http://www.merz.com/research_and_development/neramexane_tinnitus/neramexane/index.jsp

From their annual report, 2012, Merz wrote their phrase III clinical trial failed to demonstrate significant amelioration of tinnitus symptoms, i.e., the drug did not meet standards necessary for approval.

http://download.merz.de/media/publi...pdf/en/EN_Merz_GB11-12_01-Umschlag_121122.pdf
(also attached)

 

[Frédéric]

Just to recall the reference of the clinical trial:
https://clinicaltrials.gov/ct2/show/NCT00405886
Status: still completed. Study completion date: March 2007.

@jazz, thanks for posting the results. However, according to this link below, results were rather conclusive:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3031239/

As @jazz mentioned, the study of this compound has been resumed by the Japanese company Kyorin, see:
https://www.tinnitustalk.com/threads/krp-209-neramexane-by-kyorin.16400