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Introduction: During the last decade, a number of candidate drugs for the treatment of tinnitus have emerged with the hope of alleviating the...
Otonomy posted their 1st quarter financial results today. I think most of the stuff in there is already known, however, it gives a nice short...
The results have been published: https://www.ncbi.nlm.nih.gov/pubmed/29712507 The full article is freely available, too! ;)...
Only slightly interesting despite the title: Apawu AK, Curley SM, Dixon AR, Hali M, Sinan M, Braun RD, Castracane J, Cacace AT, Bergkvist M, Holt...
Quite interesting. If it would be possible to take a high-resolution look at the cochlea of people with T/HL, this would probably be a game...
Not really big news, as Auris already announced they would continue the phase 3 trial with an "amended protocol". Seems like that restart just...
But don't you know that Big Pharma is not in control because all their T advances are destroyed by the mighty hearing aid industry? I read it on...
Didn't see that coming... This might be of interest for people taking part in the AM-101 (or similar) trial or having intratympanic steroid...
https://www.boehringer-ingelheim.com/press-release/china-southeast-university-collaboration-develop-hearing-loss-treatments 360 million people...
I guess the study finished, at least there's a matching publication: https://www.ncbi.nlm.nih.gov/pubmed/27716604
Well, sometimes you stumble upon strange things. This is definitely one of 'em... ;) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4803736/...
Just wanted to post this, too, but obviously it's old news. ;) Anyway, wanted to give this a boost as not all humble bundle customers might have...
Action on Hearing loss funds research on stem cell delivery. [...] Back in 2012, we funded Professor Marcelo Rivolta, at the University of...
See their NEWS page entry from September 1st (unfortunately there's no direct link to the article, only to the news page). PRAGMA Therapeutics...
Hmm, just stumbled over a previous study where they injected Gacyclidine (OTO-311) into the ear: Effects of extracochlear gacyclidine perfusion...
See the post of @James White above. Otonomy has taken over the research, and this is probably OTO-311. Otonomy Press Release
Wow, didn't expect this: The study included 33 subjects with noise-induced hearing loss diagnoses, of which 22 (66.7%) were men. Authors...
Hmm, you can find strange things on the internet: Boehringer-Ingelheim offers a $15k bounty for the Identification of Druggable Targets to...
Well, seems like AUT00063 is useless for age-related hearing loss, too. They just posted results for the CLARITY-1 study, and it didn't do...
Initially, we’re looking at ototoxicity as a targeted market. [...] Then there’s a larger population: noise-induced hearing loss, like what’s...
From the press release: "Top-line results from the TACTT2 and TACTT3 trials are expected in August 2016 and in the fourth quarter of 2016,...
Seems like it's almost there... [...]The US Food and Drug Administration (FDA) has granted fast track designation for Keyzilen™ (AM-101) in...
More interesting basic research on how hair cell regeneration works. Action on hearing loss has a nice article summarising the result. Or take a...
Seems like they're trying to find other uses for the drug. Reading this it seems like the CLARITY-1 trial is doing better than their QUIT-1 trial...
Sorry to Dis-dissapoint you ;), but "[...]the Data Safety Monitoring Board (DSMB) for the Phase 1/2 clinical trial of CGF166 in patients with...
Somewhat off-topic, but I just stumbled over an interesting article in Scientific American about chronic pain. While it's not about tinnitus, it...
Saw this, too. However, seeing that they still list Merz/Neramexane I wouldn't count on this report being up to date. I don't think it contains...
I wouldn't get my hopes too high. Seeing that there was really no difference between placebo and AUT00063 and considering that they had ~80...
Not sure why no one found this yet, but Autifony posted a summary of the QUIET-1 study:...
Actually, dead hear cells don't leave any free seats either for the stem cells. They are replaced by supporting cells to protect the underlying...
Obviously, that yellow guy habituated pretty well, just look at him. So why should he risk his health swallowing some untested drug? ;)
Sorry to say, but that's NOT what they are saying. hey did preliminary experiments on Chinese ovary hamster cell cultures which evaluated one...
Ohh, just found this on the net: There's a study being conducted in Pittsburgh where they try this "balloon dilation" procedure for ETD. Seems...
I guess you already saw an ENT about the issue? What kind of ETD do you have? Clogged tubes? In that case, regular (and careful) nasal irrigation...
Sorry, just saw that Glynis already gave basically the same answer.
Hi Sarah, don't panic. There's indeed something moving in your skull, it's your jawbones. Hearing it from time to time is normal. You could ask...
I didn't mean when screening molecules, but before entering phase I in humans. You have to do some tests, and as far as I know for toxicity tests...
They did that, but studies showed that this stuff is just as fake as most other therapies. There are studies showing benefit of those therapies,...
There are tons of tests to be done before a drug can even enter human trials. Concerning the vast amount of potential drugs tested each year, I...
B.t.w., just a quote from an article in the Time magazine with a leading Alzheimer researcher: "My biggest frustration is that we’ve cured...
If you don't care about it, it's no problem if you can't mask it. For example, after my T got bad, it was real hard for me to concentrate and be...
Apart from the issues listed there, a vestibular schwannoma normally causes high-frequency hearing loss and T, often only in one ear (although you...
It's there, it's as loud as ever, with as many different frequencies. But I don't notice it for a long time, and when I notice it, I don't care no...
There's a good reason new drugs take so long until they even start Phase I studies....
Uhh, where did you find this information?
Well, there are many many people taking this kind of drugs, compared to the number of people that get stem cell treatment or gene therapy. So the...
Me. I have HL and T in my left ear. I don't know how bad your HL is, but mine is worst at around 2kHz, where I lost ~50kHz according to my last...
Same here, happy and content, and I'm just fighting to get there again. And slowly, it's working.
Hi glynis, just out of curiosity, what dose of prednisolone do you take? Did the T go away on the first day already? And what's the stuff you're...
Btw, for those with Meniere's: The European part of the OTO-104 Phase III trial just started....
Some googleing brought up a book by Dr. Eberhard Biesinger "Tinnitus - Endlich Ruhe Im Ohr" (rough translation: Tinnitus - Silence in your ear at...
"Profiles of NMDA-R antagonists in clinical development for the treatment of tinnitus" According to the booklet it was presented in the...
I don't think there's any condition where cuddling won't help. My girlfriend has been a real great support. And my cat, too. I think there's even...
Hi @Steve , Thanks for the report! I browsed the booklet and saw that one of the posters (P111) is from Autifony concerning their AUT00063...
Interestingly, there is a trial for Ambroxol as a cure for Parkinson......
The patent states that it can be compared to Lidocaine, which seems to be useful (there's a discussion in the treatments section about it) but can...
Has someone here noticed any difference to their tinnitus when taking Ambroxol? It's the active ingredient of several cough medicines and seems...
One more thing. I just got hold of the paper. It seems to be pretty basic research. They did some computational biology (i.e., simulations) to...
Time to try another drug? ;) Interesting side node: While googling this stuff, I came across the following post on a German forum:...
