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For the record, I have bilateral neurotinnitus, the infamous high pitch EEEE that is in the head but that is not the type of tinnitus I am having...
Just recently found out about the results from FX-322's Phase 2a clinical trial. I'm quite disheartened but I can't say I'm surprised as I...
That is good evidence. I like this support to the arguments. I'm glad this is true.
See, the point that I was trying to make is not to say "this doesn't work" but to give a plausible explanation that's different from just a dosage...
I am not throwing skepticism out there but discussing possibilities that there can be issues. I think my thought processing is logical and...
If there's no molecular guide, then I assume it's random. If it's not random, what mechanism will cause them to correctly grow toward the nerve? I...
I did post the alternative explanation in post #10981. I'll paste it here since there seems to be people not reading completely. Whether you agree...
I think you are missing an important aspect I'm trying to make. It's not just a matter of a drug plopping down a new neural cell. It's the fact...
Again, like @FGG stated, the in vitro study can not confirm if these hair cells are functional. They tell us the new hair cells are proliferating...
Yeah, the fact that they did not have significant improvements may show a possibility that not all hair cells are functional. You and I disagree...
Also, if you think about this logically, if you wasted all your space on faulty new hair cells, then you're permanently screwed. Carl LeBel says...
I disagree with you on that basis. If there's no evidence shown (in a properly documented scientific paper), I'm not fully convinced. NO...
I don't have evidence. Hence it's my hypothesis for a possible explanation for their phase 1 results. In my opinion, it's a valid and logical...
I'm not saying that they're lying. Have you even read my logic? I'm saying that their conclusion is based on the assumption that new hair cells...
That is one of my fears. The second is that we should identify all possibilities. I think the data from clinical phase 1 fits more in line with...
They have NOT demonstrated that ALL the new hair cells are functional. Where did you get that? Please cite to support your claims. Slides are just...
Again, my point is that we can not discount the fact that perhaps some, many, or most regenerated hair cells are non-functional And currently, we...
I think that's contradictory logic. As an investor, I would want hard proof and the least amount of ambiguities (i.e. show me proof from your...
I'm saying not all of them are dysfunctional. Some of them are connected correctly by chance. Because we don't know if there's any molecular...
Yes, thank you for pointing out I'm not a medical student. I am not. Then are you implying the PR slides are geared towards investors that have...
Like I said, personally, I need hard evidence. All these he says, she says, could have done, should have done, and etc are just that. Edit: What...
Exactly, you cannot test that and so, they did not conclusively provide evidence of it directly restoring auditory function. Assuming and...
Okay, so the whole point I want to bring this up is because: 1) I want to provide an plausible explanation why the majority of the patients did...
So the basis for my concern is that the new hair cells and the spiral ganglions are not connected to the receiving end of the cochlear nerve. The...
That is my point, which they obviously of course can not test auditory function based on their experimental procedures. Scientifically, if there...
You are confusing the Frequency Therapeutics' investor slides with research studies. Those investor slide claims it restores hearing in all...
I think there's some misconceptions that everyone who hasn't carefully read their actual animal studies here: Clonal Expansion of Lgr5-Positive...
Hey guys, I've originally only have pure tone tinnitus on my right ear due to ear infections two years ago. My symptoms have gotten worse. Left...
@Hazel I've been busy lately and haven't been checking on many posts. My primary concern for ENTs is: 1) Ear symptoms are not just an...
So with Frequency Therapeutics' recent press release, this related article popped up in my news feed:...
@Martinf Did you get your dental fillings (mercury ones) removed? If so, how did it go?
@Martinf around 14-15khz. Yours?
I don't think it will help with TTTS as that is caused by the tensor tympani muscle spasm or some disorder. The tensor tympani muscle has nothing...
Previously good ear can hear up to 15khz clearly. Now that tinnitus appeared, can no longer hear 15khz but only up to 14khz...
You can do an advance search on ClinicalTrials.gov and search by Sponsor with Hough or Oblato or Auditus (the latter two are partners with Hough)....
I've accidentally stumbled upon this on the ClinicalTrials.gov website. On PubMed, there was a pilot study, which found out that Oxytocin nasal...
@Steph1710 My bad ear has two sounds: a "eee" and the electrical static "zzzhhh". My former good ear developed the "eee" sound.
Ah. Nevermind, I forgot that FX's animal studies used gentamicin (aminoglycosides) to induce hair cell death for their in situ cochlear explant...
I don't suppose you know if it will also trigger support cell apoptosis too?
@FGG, Do you perhaps know how aminoglycosides damage the cochlea? Is it neuronal or hair cell damage, or both? Have there been proposed theories...
I stopped taking NAC after getting stomach ache and tinnitus spikes afterwards. It did not help my tinnitus.
What was your experience with this treatment? How does it feel to have the implant in your chest? Does the implant need a battery? And most...
Damn. I have tinnitus in both ears now. Good ear is no longer good.
@Christiaan Can you explain how this works exactly? Is it implanting a device into the neck and if so, what's the detail for this surgery? Does it...
I have either a hair or some needle like thing stuck in the ear drum. I have a lot of mosquitoes lately biting me and was wondering if anyone...
That's very discouraging...
It's not 10 years. It's frustrating that many either don't listen correctly or just join the bandwagon train from a fellow Tinnitus Talk member's...
Please discuss Hough Pill in the Hough Ear Institute thread. @Justin De Moss I have made a post in the Hough's thread regarding @ajc and...
@Justin De Moss, @ajc and @tommyd87 did misinterpret the answer regarding the off label use. Post #966 and specifically at the quoted answer at...
Recently, my good ear is acting up. A few days ago I noticed certain sounds would make me a crackling noise afterwards. This cracking noise sounds...
I'm sorry to say there isn't a cure or even an effective treatment to reduce tinnitus because most people, including medical professionals, do not...
Is this invasive? Sorry, I haven't kept up with the vagus stimulation treatment research.
Not just FREQ but EARS, OTIC are also dropping.
The fundamental concept to your idea is, at our current understanding, is not entirely correct. The assumption is that "damaged" out hair cell...
It looks connected. You have really clean ear canals btw. When I used my otoscope my ear canal has so much junk. Best wishes when you see the ENT.
I'm not a doctor nor have experience but... it looks like cholesteatoma. It usually takes a while for it to build up. Have you looked at your ear...
Developed a really loud unmaskable static hiss after the hour long fleeting tinnitus. The unmaskable nature is driving me nuts!
Me neither but if it truly eliminates tinnitus... and FX-322 doesn't work... this is the only route left. Then again, I don't think it's worth if...
Seems like your tinnitus spikes during sleep. Do you have some kind of TMJ issues? Do you grind your teeth at night that can aggravate your...
Out of curiosity, wouldn't something like canalostomy (which drills a hole through the canal into the endolymph) introduce risks for symptoms to...