Aripiprazole (Abilify): Case Reports of Diminishing/Lowering Tinnitus

I am staring at a bottle of this right now. My psychiatrist has been trying many different antidepressants over the last year. We have made our way through SSRIs, tricyclics, tetracyclics, and now atypical antipsychotics. Everything up until the antipsychotics spiked my tinnitus.

I started with Quetiapine, but it would knock me out and leave me drowsy and mentally foggy all the time. However, it did not affect my tinnitus. So now I have Abilify.

I am going to give it a try next week.

It appears to be both a dopamine D2 agonist and antagonist, depending on the level of dopamine present. It is supposed to balance dopamine levels appropriately.
I'm taking my first dose now. I had been trying to wait and see if my tinnitus spike would settle, so I could better evaluate how it might be affected. But since it has been a month with no signs of improvement, I have decided to start taking Abilify.
 
I'm taking my first dose now. I had been trying to wait and see if my tinnitus spike would settle, so I could better evaluate how it might be affected. But since it has been a month with no signs of improvement, I have decided to start taking Abilify.
Let us know how it goes.
 
After taking my first dose yesterday (2 mg), my tinnitus felt calmer than usual for an hour or two, possibly close to the level it was before my trip to Los Angeles. However, after that, the usual intense hissing that antidepressants tend to cause returned.

I also felt somewhat nauseous, and my hands were shaky and unsteady. That made me a bit nervous, as I do not want to risk developing dyskinesia from this drug. Because of that, I doubt I will continue taking it.

This drug appears to have a very long half-life, about 75 hours, so it will likely take around two weeks for it to be completely cleared from my system.
 

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