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Autifony Therapeutics and Boehringer Ingelheim

Michael Larsen

Member
Author
Aug 1, 2016
92
Tinnitus Since
2000
Cause of Tinnitus
Noice
https://autifony.com/

Boehringer Ingelheim and Autifony Therapeutics Limited ("Autifony") today announced that they have signed an agreement about certain aspects of Autifony's voltage gated potassium channel modulator platform. Boehringer Ingelheim now has an exclusive option to purchase Autifony's Kv3.1/3.2 positive modulator platform.

Both Autifony and Boehringer Ingelheim have a strong interest to explore the Kv3.1/3.2 mechanism for other indications, including hearing disorders
 
It's for schizophrenia and other CNS disorders.

Well... a recent (december 2017) researchpaper still reported positive effects of kv3.1 modulation with aut63 (failed in trails) on fast spiking neurons in the auditory pathway (read: tinnitus). The abstract of the paper is accessible on pubmed:

https://www.ncbi.nlm.nih.gov/pubmed/29235497/

The difference between the failed trail on humans and this research was the focus on direct cellular interaction (lab trail) and direct injection of the compound (aut63) in mice brains.

Probably the scientist behind this compound still believe in success via another route for administration (injection instead of pills). The partnership with Boehringer Ingelheim could be related with this new insight.
 

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