Rinri Therapeutics

Research in the UK, human trials for sensorineural hearing loss in 1-2 years - Rinri Therapeutics

Tinnitus Talk Podcast episode from 2019:

→ Episode 5: Hearing In, Tinnitus Out — Prof. Marcelo Rivolta

 

Interesting. Are they making a distinction between hair cells and neurons, with the emphasis being on fixing neurons? Bit confused after reading their website.

 

This is the email I received from Nottingham Biomedical Centre, about the research taking place at Sheffield University.

You MUST meet at least one of the criteria below to complete the survey.

I'm not sure if you need to be in the UK or not to complete the survey. It probably doesn't matter.

However, you MUST meet at least one of the criteria above!

@UKBloke, I took it as they are not focused on IHC/OHC/synapses but on the auditory nerves. They say about 75% have hearing loss due to damage of these nerves. I have to say I'm not clear myself on this.

 

Just took a bit of a deeper dive on this. Long and short from what I can gather:

• In surgical studies they utilised a synchotron x-ray to heatmap the cochlear with the (succesful) aim of targeting a surgical delivery route for their therapy.
• Therapy seems to be stem cell based.
• Current target appears to be spiral ganglion, so we're looking at auditory neuropathy/speech-in-noise/hidden hearing loss type of situation (some studies suggest the tinnitus associated with this may be the low rumbling <1000 Hz type.

 

New article about Rinri. Three drugs seem to be in the pipeline, with Phase 1 trial for the first drug starting in 2024.

Stem cell therapy: a potential cure for hearing loss?

 

"Its lead product is Rincell-1, a first-of-its-kind inner ear cell therapy that hopes to recover sensorineural hearing loss, specifically hearing loss caused by damage to the auditory nerves in the cochlea."​

That sort of cleared it up a bit for me. Using more objective measures through the use of Cochlear Implants should be better than speech-in-noise or word recognition tests.

Rinri Therapeutics have the funding and don't need to rely on the dreaded stock market + they are tied to a university!

 

Looks like HOPE is back on the menu, boys.

 

@LAnative, you will need to follow them closely. You are unlikely to see the media coverage and self-promotion you see with some biotechs, which is why they are under the radar.

 

Rinri Therapeutics' Board of Directors still seems to be filled with biotech industry folks, right? Even Frequency Therapeutics liked to mention their connections to Harvard and MIT.

I suppose the hope here is that Rinri Therapeutics do not become publicly traded so as to not puff up their prospects?

 

Great news.

 

Hello, all. Long time occasional lurker, first time poster, going to jump right into it. (My apologies in advance if I break any implicit conventions or rules, please correct me.)

Rinri Therapeutics claims:

This raises some questions for me. They are confidently stating that they now have a correct understanding of the human auditory development at a molecular level after past failures. On what basis if they're preclinical? Do they even have animal models? The one study I see cited states in the abstract only in vitro testing, and testing in an "auditory neuropathy model".

Every one of these labs, public, private, or non-profit affiliated gives me hope as it adds to our body of knowledge on the issue, but I want to have an accurate assessment of what's been accomplished vs. hype.