Autifony Therapeutics Phase II Study for AUT00063, for the Treatment of Hearing Loss and Tinnitus

Discussion in 'Research News' started by attheedgeofscience, Sep 19, 2014.

    1. LondonGirl

      LondonGirl Member

      Tinnitus Since:
      11/2013
      There have been a few posts on this thread suggesting how one might 'blag' onto the trial despite not meeting the criteria. I'm not sure how serious people are (hard to 'get' tone of voice in an email). But can I respectfully suggest that however c*** we may feel, such action could mess things up for the long term viability of the drug going to market eventually and maybe helping a vast number of us sufferers. If you want to prove you can pole vault you start low and gradually increase the height. That's what drugs companies have to do. Otherwise they won't get the investment to progress the trials further.
       
      • Agree Agree x 3
      • Winner Winner x 1
    2. dboy
      Jaded

      dboy Member Benefactor

      Location:
      UK
      Tinnitus Since:
      1/2007 & 8/2013
      Plus, in my experience they sometimes repeat frequencies/volumes to double check the thresholds. I don't think it would necessarily be that easy to fake it consistently enough if they have a halfway decent audiologist. And, of course, lying is bad karma.
       
      • Agree Agree x 1
    3. Rube
      Fine

      Rube Member Benefactor

      Location:
      USA
      Tinnitus Since:
      7/2014
      Cause of Tinnitus:
      Loud shit
      Probably for all of phase 2.
       
    4. Christian_B
      No Mood

      Christian_B Member

      Location:
      Denmark
      Tinnitus Since:
      07-2014
      Im not on this forum so much anymore, because i think too much on my T. when searching this board all day long.

      Because of that, i'm not really up-to-date on the Phase-1 trial. did it show any success results released to the public? does any know about that? :)
       
    5. dan
      Chatty

      dan Member

      Tinnitus Since:
      06/2011
      yeah yeah it was a success - we're into phase 2 now.
       
    6. Marius T
      Fine

      Marius T Member

      Location:
      Marseille, France
      Tinnitus Since:
      08/2014
      Hello can someone tell me if the autofony trials had some success on ppl on this thread (don't really want to read another entire thread..) ? Thank you :)
       
    7. lapidus

      lapidus Member Benefactor

      Location:
      Sweden
      Tinnitus Since:
      1999
      Cause of Tinnitus:
      Noise induced
      The phase 2 trials hasnt begun yet. There has only been a phase 1 trial so far and in that they only tested the safety of the drug on people without T.
       
    8. Marius T
      Fine

      Marius T Member

      Location:
      Marseille, France
      Tinnitus Since:
      08/2014
      @lapidus Okay well that's why I couldn't find anyone.. when do you think the phase 2 is going to begin?
       
    9. lapidus

      lapidus Member Benefactor

      Location:
      Sweden
      Tinnitus Since:
      1999
      Cause of Tinnitus:
      Noise induced
      It's about to begin very soon. Sometime in October if everything works out.
       
    10. Marius T
      Fine

      Marius T Member

      Location:
      Marseille, France
      Tinnitus Since:
      08/2014
      Ok then and if i've fully understand you're legitable for the trials only if you have hearing loss ?
       
    11. Hudson
      Cowboy

      Hudson Member Benefactor

      Tinnitus Since:
      2003
      No, as far as we know you don't have to have a measurable hearing loss. I don't think it's a disqualifying factor either. You just have to have medically documented tinnitus. What that means is that they will want records from whatever medical provider you have seen (ENT, GP, Audiologist) who officially said "yep you have tinnitus." That way, they will know that you have had it between 6 and 18months.
       
      • Like Like x 1
    12. Rube
      Fine

      Rube Member Benefactor

      Location:
      USA
      Tinnitus Since:
      7/2014
      Cause of Tinnitus:
      Loud shit
      its mentioned on the clinical trial details:

      Hearing loss (Pure Tone Average (of thresholds at 250, 500, 1000, 2000 and 4000Hz) >20 and <60 dB Hearing Loss
       
      • Agree Agree x 1
    13. Christian_B
      No Mood

      Christian_B Member

      Location:
      Denmark
      Tinnitus Since:
      07-2014
      Just to be clear, Phase-2 will test people with T. right?
       
    14. rtwombly
      Bookworm

      rtwombly Member

      Location:
      Southeast USA
      Tinnitus Since:
      01/2014
      Cause of Tinnitus:
      Unknown
      Yes. The phase 2 trial is to prove the drug works.
       
      • Like Like x 1
    15. inadmin

      inadmin Member

      There was an inside info leaked by one of the of members here that people benefited from the drug.
       
    16. Rube
      Fine

      Rube Member Benefactor

      Location:
      USA
      Tinnitus Since:
      7/2014
      Cause of Tinnitus:
      Loud shit
      I emailed Autifony last week to see if they would provide any additional information. Here is what I received today from them:

      Thank you for your email and your interest in Autifony's clinical trial with AUT00063 in subjective tinnitus. As I am sure you will know, the clinical evaluation of any new drug proceeds in a stepwise manner, and at each step the safety and efficacy of the new drug must be thoroughly evaluated. We are just at the beginning of that process for AUT00063, and it is still too early to predict the road ahead. However, at Autifony we fully appreciate the need for an effective treatment for people suffering with tinnitus, and hope the wait will not have to be long!
       
      • Optimistic Optimistic x 1
    17. Marius T
      Fine

      Marius T Member

      Location:
      Marseille, France
      Tinnitus Since:
      08/2014
      @Rube what you're saying to me here is in contradiction with the previous @Hudson fact ..
       
    18. dboy
      Jaded

      dboy Member Benefactor

      Location:
      UK
      Tinnitus Since:
      1/2007 & 8/2013
      Rube is correct - there is unfortunately a hearing loss requirement as he describes.
       
      • Informative Informative x 1
    19. inadmin

      inadmin Member

      Hearing loss or not, 6 to 18 months, it will hit the market and then we will be able to try it.
       
    20. Rube
      Fine

      Rube Member Benefactor

      Location:
      USA
      Tinnitus Since:
      7/2014
      Cause of Tinnitus:
      Loud shit
      @inadmin Just curious where did you get this information? I would love for it to be true but doesn't seem likely for it to come to market so quickly.
       
    21. inadmin

      inadmin Member

      No i was talking about the 6-18 months T criteria.
       
    22. lapidus

      lapidus Member Benefactor

      Location:
      Sweden
      Tinnitus Since:
      1999
      Cause of Tinnitus:
      Noise induced
      No, there was not.

      Maybe you think of what attheedgeofscience said. He said that they have tested the drug on some people with T but he never said that anyone had benefit from it or not. He didnt even have a proper source to prove his statement. It's only hearsay.
       
    23. inadmin

      inadmin Member

      I stand corrected then it must be my mind and the wishful thinking playing tricks
       
    24. Christian_B
      No Mood

      Christian_B Member

      Location:
      Denmark
      Tinnitus Since:
      07-2014
      Im gonna be so sad if this doesn't work out as we hope.
       
      • Hug Hug x 1
    25. Marius T
      Fine

      Marius T Member

      Location:
      Marseille, France
      Tinnitus Since:
      08/2014
      I don't think I have hearing loss.. going to see this with my ENT doctor, but do you think that an acoustic trauma is inducing hearing loss in all cases ?
       
    26. SteveToHeal
      Insomnious

      SteveToHeal Member

      Location:
      Unknown
      Tinnitus Since:
      10/2013
      Cause of Tinnitus:
      Acoustic trauma
      From my audiologist:

      You don’t fit the criteria given, as that is describing somebody with a mild to moderate loss across the whole spectrum.

      No AUT00063 for me then :( I'm really perplexed as to why hearing loss across the whole frequency spectrum is an inclusion criteria. Anyone?
       
      • Hug Hug x 1
    27. lapidus

      lapidus Member Benefactor

      Location:
      Sweden
      Tinnitus Since:
      1999
      Cause of Tinnitus:
      Noise induced
      Arent Autifony targeting hearing loss as well? This trial maybe is a 2 birds 1 stone kinda deal?
       
      • Agree Agree x 2
      • Informative Informative x 1
    28. dan
      Chatty

      dan Member

      Tinnitus Since:
      06/2011
      Hi Steve, can you elaborate on who told you this (did you go to an Autifony recruiter?) and what exactly did he/she tell you ? Also are you in UK ?
       
    29. SteveToHeal
      Insomnious

      SteveToHeal Member

      Location:
      Unknown
      Tinnitus Since:
      10/2013
      Cause of Tinnitus:
      Acoustic trauma
      As it said in my post "my audiologist"... The Autifony hotline isn't open yet ;)
      No. I am not in the UK i'm in SA but maybe speaking English is ok enough to get on it. So i will apply and see.
       
    30. dan
      Chatty

      dan Member

      Tinnitus Since:
      06/2011
      So why would you ask this statement ? If some "audiologist" who isn't affiliated with Autifony told you this.
      I don't understand you.
       

Share This Page

Loading...