Withdrawn/Terminated Caroverine and Inner Ear Diseases

The study will investigate the transtympanic treatment with a 1,5% caroverine solution.

    1. Tinnitus Talk
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      Tinnitus Talk Knowledge Base

      Tinnitus Talk submitted a new resource:

      Caroverine and Inner Ear Diseases (version 1.0) - The study will investigate the transtympanic treatment with a 1,5% caroverine solution.

      Read more about this resource...
       
    2. Frédéric

      Frédéric Member Benefactor

      Location:
      Marseille, France
      Tinnitus Since:
      11/19/2012
      Cause of Tinnitus:
      acoustic trauma
      https://clinicaltrials.gov/ct2/show/NCT01174979
      Status: this study has suspended participant recruitment.

      Caroverine remains a big mistery.

      I remember I sent an e-mail on November 27th, 2014 to the company Phafag, the sponsor of this study, to ask for the results. They never replied me. By the way, the company’s website is very minimalist (www.phafag.at) but it markets a product named Tinnitin for tinnitus. (http://www.phafag.at/tinnitin/).

      I also sent an e-mail on January 6th, 2015 to Landeskrankenhaus Feldkirch, the investigator (medical center) of this study, to ask for the results. They replied me the day after:

      Dear Frederic,
      Thank you for writing us. I am very sorry to tell you that we canceled the trial in the end of 2010, because the company (Phafag) that initiated the trial broke down. So we are unfortunately not able to present you any results. Yours sincerely
      Joachim Kronberger


      Then, the search on the net with the sentence “caroverine and inner ear diseases” redirects to these links:
      https://www.ncbi.nlm.nih.gov/pubmed/11885656
      http://www.tinnitusjournal.com/arti...c-tinnitus-treatment-proofofconcept-study.pdf

      Two studies conducted by Klaus Ehrenberger, from the Department of Otorhinolaryngology, University of Vienna, Austria, with conclusive results.

      I sent an e-mail to Klaus Ehrenberger on January 26th, 2016, to find out where his studies have been since these last encouraging results. He never replied me.


      Finally, see also the thread:
      https://www.tinnitustalk.com/threads/tinnex-caroverine.46/

      Indeed, according to these links: http://economictimes.indiatimes.com...pray/articleshow/18116922.cms?intenttarget=no
      http://www.pharmabiz.com/NewsDetails.aspx?aid=62389&sid=2

      The indian company Lincoln Pharmaceuticals Ltd entered into an agreement with Phafag AG, Switzerland, for its Caroverine molecule for the treatment of Tinnitus. It now markets Caroverine under the brandname Tinnex.

      I sent an e-mail to Lincoln Pharmaceuticals on January 8th, 2015 to ask if they are keen on marketing Tinnex outside India (especially in France). They did not reply to me.
       
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