Current Evidence of Chinese Herbal Constituents with Effects on NMDA Receptor Blockade

Discussion in 'Health Talk' started by Danny Boy, Dec 14, 2016.

    1. Danny Boy
      Cheerful

      Danny Boy Member Benefactor Hall of Fame

      Location:
      England
      Tinnitus Since:
      7/2014
      Cause of Tinnitus:
      Ear infection
      Published online 2013 Aug 21


      NMDA receptor (NMDA-R) is an important molecular entity governing a wide range of functions in the central nervous system. For example, the NMDA-R is involved in memory and cognition, and impairment of both (as in Alzheimer’s Disease) is attributed to NMDA-mediated neurotoxicity. With greater understanding of the NMDA-R structure, antagonists with varying degrees of binding-site and subtype selectivity have been developed and put into clinical use. Discovery of target-specific Chinese herbs have also been made in parallel. This article provides an overview of the known active sites on the NMDA-R, followed by a discussion of the relevant herbs and their constituents. Experimental evidence supporting the inhibitory role of the herbal compounds on the NMDA-R is highlighted. For some of the compounds, potential research directions are also proposed to further elucidate the underlying mechanisms of the herbs. It is envisaged that future investigations based on the present data will allow more clinically relevant herbs to be identified.


      https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3817734/
       
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    2. carlover
      English

      carlover Member Benefactor

      Location:
      London
      Tinnitus Since:
      1986
    3. Bill Bauer
      No Mood

      Bill Bauer Member Hall of Fame

      Tinnitus Since:
      February, 2017
      Cause of Tinnitus:
      Acoustic Trauma
      http://www.sciencedirect.com/science/article/pii/S0965229915000035
      "After 2 months of treatment, THI and PSQI scores were reduced significantly more in the CHJLGMIT group (p < 0.05) than in the non-CHJLGMIT group. Scores on the emotional subscale of the THI were significantly reduced in the CHJLGMIT group (p < 0.05) after treatment, but the effects on the seven PSQI subscales did not differ significantly between the two groups (p > 0.05). Scores on the VAS for tinnitus loudness were significantly reduced in both groups (p < 0.05)."
       

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