Dietary Vitamin C Supplementation Reduces Noise-Induced Hearing Loss in Guinea Pigs

Discussion in 'Research News' started by Danny Boy, Feb 26, 2016.

    1. Danny Boy

      Danny Boy Member Benefactor Hall of Fame

      Tinnitus Since:
      Cause of Tinnitus:
      Ear infection
      Dietary vitamin C supplementation reduces noise-induced hearing loss in guinea pigs.
      McFadden SL1, Woo JM, Michalak N, Ding D.
      Author information

      Vitamin C (ascorbate) is a water-soluble, low molecular weight antioxidant that works in conjunction with glutathione and other cellular antioxidants, and is effective against a variety of reactive oxygen species, including superoxide and hydroxyl radicals that have been implicated in the etiology of noise-induced hearing loss (NIHL). Whereas most animals can manufacture their own vitamin C, humans and a few other mammals such as guinea pigs lack the terminal enzyme for vitamin C synthesis and must obtain it from dietary sources. To determine if susceptibility to NIHL could be influenced by manipulating dietary levels of vitamin C, albino guinea pigs were raised for 35 days on a diet with normal, supplemented or deficient levels of ascorbate, then exposed to 4 kHz octave band noise at 114 dB SPL for 6 h to induce permanent threshold shifts (PTS) of the scalp-recorded auditory brainstem response. Animals that received the highest levels of dietary ascorbate developed significantly less PTS for click stimuli and 4, 8, 12, and 16 kHz tones than animals on normal and deficient diets. Outer hair cell loss was minimal in all groups after noise exposure, but permanent damage to stereocilia were observed in noise-exposed ears. The results support the hypothesis that dietary factors influence individual susceptibility to hearing loss, and suggest that high levels of vitamin C may be beneficial in reducing susceptibility to NIHL.
    2. Asvalian

      Asvalian Member Benefactor

      Barcelona (Spain)
      Tinnitus Since:
      Cause of Tinnitus:
      Unknown at the moment, prob hearing lost/stress.
      I find interesting the fact tha vitamin C can work to prevent hearing loss, although if I'm not mistaken cannot reverse the damage done, right?
    3. Silvio Sabo

      Silvio Sabo Member Benefactor

      Gothenburg, Sweden
      Tinnitus Since:
      Cause of Tinnitus:
      Noise - I think
      Vitamin C is a potent anti-oxidant and thus can take care of free radicals that can cause damage to cells. If I'm not mistaken a cascade reaction that involves free radicals is set off in the cochlea in response to loud noise. I know that there is a cascade reaction that kills hair cells as this is what AM-101 is supposed to treat but I'm unsure about the involvement of free radicals. But I think I have read it somewhere.
      • Informative Informative x 1

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