Drug Memantine Reduces Chronic Tinnitus Caused by Acoustic Trauma

Discussion in 'Research News' started by erik, Sep 30, 2012.

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    1. erik
      Breezy

      erik Manager Staff Benefactor

      Location:
      Washington State, USA
      Tinnitus Since:
      04/15/2012
      Cause of Tinnitus:
      Most likely hearing loss
      Memantine is used to treat the symptoms of Alzheimer's disease. Memantine is in a class of medications called NMDA receptor antagonists. It works by decreasing abnormal activity in the brain.

      Yiwen Zheng, Emily McNamara, Lucy Stiles, Cynthia L. Darlingtonand Paul F. Smith*
      • Department of Pharmacology and Toxicology, Brain Health Research Centre, School of Medical Sciences, University of Otago, Dunedin, New Zealand
      Subjective tinnitus is a chronic neurological disorder in which phantom sounds are perceived. Increasing evidence suggests that tinnitus is caused by neuronal hyperactivity in auditory brain regions, either due to a decrease in synaptic inhibition or an increase in synaptic excitation. One drug investigated for the treatment of tinnitus has been the uncompetitiveN-methyl-D-aspartate (NMDA) receptor antagonist, memantine, although the evidence relating to it has been unconvincing to date. We re-investigated the effects of memantine on the behavioral manifestations of tinnitus induced by acoustic trauma (a 16-kHz, 110-dB pure tone presented unilaterally for 1 h) in rats. We used a conditioned lick suppression model in which lick suppression was associated with the perception of high frequency sound resembling tinnitus and a suppression ratio (SR) was calculated by comparing the number of licks in the 15-s period preceding the stimulus presentation (A) and the 15-s period during the stimulus presentation (B), i.e., SR = B/(A + B). Acoustic trauma resulted in a significant increase in the auditory brainstem-evoked response (ABR) threshold in the affected ear (P≤ 0.0001) and a decrease in the SR compared to sham controls in response to 32 kHz tones in five out of eight acoustic trauma-exposed animals. A 5-mg/kg dose of memantine significantly reduced the proportion of these animals which exhibited tinnitus-like behavior (2/5 compared to 5/5; P ≤ 0.006), suggesting that the drug reduced tinnitus. These results suggest that memantine may reduce tinnitus caused by acoustic trauma.
       
      • Like Like x 1
    2. mock turtle

      mock turtle Member

      Location:
      puget sound
      Tinnitus Since:
      07/26/1992...habituated after 2 years; 11/04/11 new outbreak
      erik, thanks for the information

      yep, makes sense

      the vast majority of neuro connections are made by the transmitter glutamate... and memantine antagonizes glutamate

      nmda receptors require glutamate and glycine to make the connection and memantine inhibits nmda receptors

      i keep wondering if most of us who sufferer from tinnitus are type A personalities ...people that are "excitable" and high energy...and therefore things that get us to key down, slow down, amp down will help alleviate tinnitus ? !

      best wishes
      mock turtle
       
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    3. Fish
      Balanced

      Fish Member Benefactor

      Location:
      Poland
      Tinnitus Since:
      July 2012
      I thought I would mention this - ketamine, a drug often taken recreationally, is an antagonist that blocks NMDA receptors. So is AM-101...

      If NMDA antagonists could reduce "chronic" tinnitus, why then AM-101 can only be used up to 3 months since onset?

      And by the way, I know it's for greater good, but I think intentionally causing acoustic trauma in rats is kind of cruel :(
       
      • Like Like x 1
    4. Carlos Galiano

      Carlos Galiano Member

      Tinnitus Since:
      12/2014
      Nadie ha intentado este medicamento?
       
    5. Twitch

      Twitch Member

      Location:
      Earth
      Tinnitus Since:
      2014
      Cause of Tinnitus:
      Unknown
      Seeing as this 3 year old thread was recently necro'd, I thought this would be a perfect opportunity to share a link I bookmarked many moons ago:

      Memantine completely cured my tinnitus!

      Interesting that Memantine/Namenda cured his Celexa/citalopram drug induced tinnitus albeit temporarily. His T returned when he continued dosing another antidepressant Tianeptine.
       
      • Like Like x 2
    6. Carlos1

      Carlos1 Member Benefactor

      Location:
      Boston
      Tinnitus Since:
      08/2013
      Cause of Tinnitus:
      Root Canal
      Has anybody tried Memantine ?
       
    7. markoana

      markoana Member

      Tinnitus Since:
      2.2013
    8. JasonP

      JasonP Member

      Tinnitus Since:
      6/2006
      Anyone tried this?
       
      • Good Question Good Question x 1
    9. Beste
      Disappointed

      Beste Member

      Tinnitus Since:
      02/16/2016
      Cause of Tinnitus:
      Benzo/Clonazepam, Stress
    10. lapidus

      lapidus Member

      Location:
      Sweden
      Tinnitus Since:
      1999
      Cause of Tinnitus:
      Noise induced
      Abstract from a clinical study on Memantine called "Tinnitus Treatment with Memantine" (i.e., Namenda).

      Authors: Figueiredo RR, Langguth B, Mello de Oliveira P, Aparecida de Azevedo A.

      Affiliations: OTOSUL-Otorrinolaringologia Sul-Fluminense, Volta Redonda and Valenca, Brazil; Valenca Medical School, Rio de Janeiro, Brazil.

      Publication date & source: 2008-04, Otolaryngol Head Neck Surg., 138(4):492-6.

      OBJECTIVE: To evaluate efficacy and safety of memantine in the treatment of tinnitus.

      STUDY DESIGN: Prospective, randomized, double-blind crossover study.

      SUBJECTS AND METHODS: A total of 60 patients with tinnitus were randomized into a double-blind, placebo-controlled, prospective crossover study. Patients each received up to 20 mg memantine and placebo for 90 days, separated by a 30-day washout period. Treatment effects were assessed by using the Tinnitus Handicap Inventory (THI). A total of 43 patients completed the trial.

      RESULTS: There was no significant improvement of THI score after memantine treatment compared with placebo. A possible tendency for delayed effects of memantine was observed. The incidence of side effects during memantine treatment was 9.4 percent, leading to interruption of treatment in all cases.

      CONCLUSION: This study does not provide evidence to recommend memantine for the treatment of tinnitus. A possible late effect of the drug should be evaluated in further studies with longer observation periods.
       
    11. Poyraz

      Poyraz Member

      Tinnitus Since:
      February 2016
      Cause of Tinnitus:
      Benzos, Stress, Anxiety, Loud Music, Jaw Problems. Who knows
      And there goes my hopes away...
      What kind of hell is this? Why God..
       
      • Agree Agree x 1
    12. adrian_em

      adrian_em Member

      Tinnitus Since:
      2012
      Cause of Tinnitus:
      Firearm
      You will habituate. My ears are screaming and I'm fine now 3 months after acoustic trauma. Until a cure will be found, go to Back to silence thread and read.
       
    13. Ears Hurt

      Ears Hurt Member

      Location:
      USA
      Tinnitus Since:
      10/2012
      Cause of Tinnitus:
      Whiplash or Buzzer (abuse from ex)
      Been doing that and still waiting for silence
       
    14. Beste
      Disappointed

      Beste Member

      Tinnitus Since:
      02/16/2016
      Cause of Tinnitus:
      Benzo/Clonazepam, Stress
      Hi Ears Hurt
      Can I ask how long have you been taking this drug? No reducing in T even a bit?
       
    15. Aussie Lea
      Dramaqueen

      Aussie Lea Member

      Location:
      Melbourne Yarra Valley
      Tinnitus Since:
      01/09/2013
      Why all tinnitus drug trials are unsuccessful??
       
    16. Sailboardman
      Frustrated

      Sailboardman Member Benefactor

      Location:
      Florida
      Tinnitus Since:
      04/21/2014
      Cause of Tinnitus:
      Sensorineural hearing loss right ear.
      Finding a drug to cure Tinnitus, is like finding a needle in a haystack! Actually, That would be easier.
       
    17. Ludwig
      Aggressive

      Ludwig Member

      Tinnitus Since:
      17 february 2016
      Cause of Tinnitus:
      Acoustic trauma
      I believe that the "selectivity of the sample" is a problem. Different sounds, different damage at different levels, different people, different T.
      I don't know if for everyone the T it's just a neural damage. For me there is a sort of particular that still escapes. What is, no one knows.

      In my case: acoustic trauma - hearing loss on high freq. for left hear - something wrong in my mind or also a damage to the synapses of the auditory nerve - Tinnitus.
      For example... i think that if my hearing came back perfect I imagine that tinnitus would remain. I think it is no longer a problem of hair cells. This is the begin but after...
      After all no one deafen with their tinnitus. There are people with a 90 decibels of T. But it does not worsen hearing. So where is this sound? Certainly does not pass from the ear.
       

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