Flupentixol and Melitracen on Curative Effect of Sudden Deafness Patients w/ Anxiety and Depression

Discussion in 'Research News' started by Frédéric, May 22, 2018.

    1. Frédéric

      Frédéric Member Benefactor

      Location:
      Marseille, France
      Tinnitus Since:
      11/19/2012
      Cause of Tinnitus:
      acoustic trauma
      I found this article today:

      Observation of Flupentixol and melitracen on curative effect of sudden deafness patients with anxiety and depression in different stages
      Zhang T , Yu GD
      Department of Otolaryngology Head and Neck Surgery, Affiliated Hospital of Guizhou Medical University, 550002, Guiyang,China.

      Abstract

      Objective:To investigate the efficacy of flupentixol melitracen on different stages of sudden deafness patients with anxiety and depression.Method:Totally one hundred and sixty-three sudden deafness patients with anxiety and depression were randomly divided into two groups: experimental group(81 cases) and control group (82 cases). All patients were given routine treatment for 2 weeks. The experimental group was given oral flupentixol melitracen (1 tablet/day)for a period of 3 months. The hearing, tinnitus effect and vertigo treatment course were observed and compared. Curing rate of tinnitus at 2 weeks, 3 months and 6 months after treatment, self-rating anxiety scale (SAS) and depressive state scale (self-rating depression scale, SDS) score were collected and compared.Result:Total efficiency of hearing and tinnitus of experimental group(86.42%,84.21%)were higher than that of the control group(67.07%,61.29%);the vertigo cured the average treatment time of experimental group days was less than that of the control groupdays,all the differences were statistically significant.After treatment,the average hearing threshold value of the two groups of patients were lower than that before treatment,the low frequency descent type, high-frequency descent type,flat down type and total deafness type thresholds of the experimental group were lower than of the control group,all the differences were statistically significant.The tinnitus cure rate of experiment group were higher than the control group at 3months and 6 months after treatment,the differences were statistically significant;and after 3months and 6 months treatment tinnitus cure rate higher of the experimental group than that of after 2 weeks the treatment,the difference was statistically significant.After 2 weeks,3 months and 6 months treatment,the SAS and SDS scores of two groups were lower than that before treatment.The SAS and SDS scores of the experimental group decreased after 2 weeks,3 months and 6 months treatment, and the difference was statistically significant at different time points,the SAS,SDS scores of experimental group after treatment were lower than the control group at the same time,the differences were statistically significant.Conclusion:For the sudden deafness patients with anxiety and depression , the combination of flupentixol melitracen on the basis of conventional therapy can improve the clinical efficacy, the patient's mental status and long-term therapeutic effect of tinnitus.

      Link: https://europepmc.org/abstract/med/29771077
       
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    2. grate_biff
      Alone

      grate_biff Member Benefactor

      Location:
      Oslo, Norway
      Tinnitus Since:
      09/2014
      Cause of Tinnitus:
      Acoustic trauma, benzo/mirtazapine withdrawal, or combo!
      Flupentixol actually helps my tinnitus. I take 1 mg as needed.
       
    3. Daniel Lion
      Ape-like

      Daniel Lion Member Podcast Patron Benefactor Hall of Fame

      Location:
      SE Asia
      Tinnitus Since:
      2017
      Cause of Tinnitus:
      Noise trauma, hearing loss
      How does it help?
      What are the effects like?
      Could you describe a bit, I have never heard of this drug.

      Thanks.
       
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    4. grate_biff
      Alone

      grate_biff Member Benefactor

      Location:
      Oslo, Norway
      Tinnitus Since:
      09/2014
      Cause of Tinnitus:
      Acoustic trauma, benzo/mirtazapine withdrawal, or combo!
      I take it before bedtime and my tinnitus will be much lower the next day. Sometimes, when I take it 3 days in a row it can totally quiet my tinnitus.
      Weak anxiolytic and antidepressant effect in addition to said effect on tinnitus.
      It´s an antipsychotic med, but also used in withdrawals of different kinds.

      As I understand it, it works on selected serotonin receptors, all dopamine receptors and as an antihistamine. It´s not approved in the US though. See if you can get it in SE Asia.

      I learned of its effect on my tinnitus purely by accident. Can be because I´m in severe benzo withdrawal.

      https://en.wikipedia.org/wiki/Flupentixol
       
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    5. Daniel Lion
      Ape-like

      Daniel Lion Member Podcast Patron Benefactor Hall of Fame

      Location:
      SE Asia
      Tinnitus Since:
      2017
      Cause of Tinnitus:
      Noise trauma, hearing loss
      Thanks for the info.

      Sounds very effective... cheers for that.
       
    6. all to gain

      all to gain Member

      Tinnitus Since:
      June 2019
      Cause of Tinnitus:
      ototoxic reaction
      Flupentixol gave me terrible side effects.
       
    7. FGG

      FGG Member Podcast Patron Benefactor

      Tinnitus Since:
      01/2019
      Cause of Tinnitus:
      Multi-factorial
      They use this class of drugs as an antiemetic, too. I had a similar drug in the same class when i had a vestibular attack and it gave me akathasia for days.

      Most people tolerate it fine from what the nurse told me but it can give terrible side effects (like the akathasia) in some people.
       
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    8. all to gain

      all to gain Member

      Tinnitus Since:
      June 2019
      Cause of Tinnitus:
      ototoxic reaction
      Yes, I had the same side effects. So I went off it, only for my tinnitus to be then caused by a too bigger increase in Prozac and Propranolol.

      I would take the akathasia over the tinnitus any day.

      But it was still horrible.
       
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