Frequency Therapeutics — Hearing Loss Regeneration

Discussion in 'Research News' started by RB2014, Dec 8, 2016.

    1. JohnAdams
      Studious

      JohnAdams Member Benefactor Hall of Fame

      Location:
      Nasty Swamp
      Tinnitus Since:
      May 1st 2018
      Cause of Tinnitus:
      Aspirin Toxicity/Possibly Noise
      Hey man it's cool, I'm an irritable jerk. We are all in the same boat here.
       
      • Like Like x 2
      • Friendly Friendly x 1
    2. JohnAdams
      Studious

      JohnAdams Member Benefactor Hall of Fame

      Location:
      Nasty Swamp
      Tinnitus Since:
      May 1st 2018
      Cause of Tinnitus:
      Aspirin Toxicity/Possibly Noise
      FX-322 causes the supporting cell to divide first.
      I don't know, maybe someone else does.
       
      • Helpful Helpful x 1
    3. JohnAdams
      Studious

      JohnAdams Member Benefactor Hall of Fame

      Location:
      Nasty Swamp
      Tinnitus Since:
      May 1st 2018
      Cause of Tinnitus:
      Aspirin Toxicity/Possibly Noise
      I have sent my resume.
       
      • Like Like x 6
      • Agree Agree x 1
      • Genius Genius x 1
    4. Fightthearmy

      Fightthearmy Member

      Tinnitus Since:
      2012
      Cause of Tinnitus:
      work-related
      For each one who says the clinical trial system is broken, there are three or more people who think the former are full of cr*p. Hence no speedup.
       
      • Like Like x 1
    5. JohnAdams
      Studious

      JohnAdams Member Benefactor Hall of Fame

      Location:
      Nasty Swamp
      Tinnitus Since:
      May 1st 2018
      Cause of Tinnitus:
      Aspirin Toxicity/Possibly Noise
      NEAT!

      Tell them thanks for approving drugs that gave many of the people here tinnitus!
       
      • Agree Agree x 3
    6. Pero1234

      Pero1234 Member

      Tinnitus Since:
      02/2018
      Cause of Tinnitus:
      home theatre system + high pressure washer
      Plottwist... he already is :)
       
      • Funny Funny x 3
      • Agree Agree x 1
      • Informative Informative x 1
    7. AUTHOR
      AUTHOR
      RB2014
      Confused

      RB2014 Member Benefactor

      Location:
      US
      Tinnitus Since:
      12/2014 became noticable
      Cause of Tinnitus:
      Loss of hearing and then stress and anxiety
      I hope you're serious and I hope you get the job. We need someone in their team batting for us.
       
      • Agree Agree x 3
      • Like Like x 1
    8. JohnAdams
      Studious

      JohnAdams Member Benefactor Hall of Fame

      Location:
      Nasty Swamp
      Tinnitus Since:
      May 1st 2018
      Cause of Tinnitus:
      Aspirin Toxicity/Possibly Noise
      I'm not elite enough to work for them. I also don't have enough lab experience.
       
      • Like Like x 1
      • Hug Hug x 1
    9. Fightthearmy

      Fightthearmy Member

      Tinnitus Since:
      2012
      Cause of Tinnitus:
      work-related
      So there remains a lot of work left getting the dosage and dosing schedule right. However, they did see *some* improvement. That's a lot more than ANY currently available treatment offers, and presumably for tinnitus as well. But if the FDA says I have to wait til I'm 80 years old to get improvement (even a slight one), then it's no use boasting around how incredibly fast the FDA is, as the FDA executives and David Kessler are doing. * EVERYTHING IS SHIT *
       
    10. WickedCarnival

      WickedCarnival Member

      Tinnitus Since:
      Late Autumn 2016
      Cause of Tinnitus:
      Unsure between azithromycin or viral infection
      I hope they team up with Otomagnetics so that they can get the molecules into the inner ear more effectively, rather than just a crude injection with a needle:

      Otomagnetics Magnetic Injection Technology
       
      • Agree Agree x 4
      • Like Like x 1
    11. JohnAdams
      Studious

      JohnAdams Member Benefactor Hall of Fame

      Location:
      Nasty Swamp
      Tinnitus Since:
      May 1st 2018
      Cause of Tinnitus:
      Aspirin Toxicity/Possibly Noise
    12. john paul
      English

      john paul Member

      Tinnitus Since:
      11/11/17
      Cause of Tinnitus:
      acoustic trauma
      ^^^ eventually it will happen.
       
      • Agree Agree x 4
      • Like Like x 1
    13. Fightthearmy

      Fightthearmy Member

      Tinnitus Since:
      2012
      Cause of Tinnitus:
      work-related
      EVENTUALLY you'll be six feet under.
       
      • Agree Agree x 1
    14. Aleksa Uzunovic

      Aleksa Uzunovic Member

      Tinnitus Since:
      2014
      Cause of Tinnitus:
      Noise induced hearing loss
      Maybe the Chinese have some treatment as their system is extremely efficient and they would approve it as soon as the treatment is proven to be safe and effective?
       
    15. tomytl
      Grumpy

      tomytl Member Benefactor

      Tinnitus Since:
      10 Years
      Cause of Tinnitus:
      unknown
      I guess delivery is less of a problem than triggering the correct cells in the inner ear to regrow and develop. The Draper Lab has been developing such a device years ago.
      But no worries, they work hand in hand. Things are amazing and if there is proof of regeneration with hearing enhancement the future will bring many different approaches.

      I guess the next 3 years will show what we can expect in the nearer future.
       
      • Agree Agree x 2
      • Like Like x 1
    16. Stoie

      Stoie Member

      Tinnitus Since:
      June 2018
      Cause of Tinnitus:
      Unknown / Nsaids
      Frequency Therapeutics's press release mentioned "signs of functional hearing improvement" but that could mean a broad range of results, from 3 dB to 20 dB. To my knowledge even 3 dB could make some people understand spoken words better given it doubles the perceived volume.

      To be honest sometimes their pitches, articles or rumours seem extremely well put together pieces of PR stuff, promising the moon to some (like some of us folks here) while to the skeptical eye nothing really exact in the event things go sideways.

      Guess we have to wait for the statistical data if they will release anything specific of it this year for Phase 1/2.
       
      • Like Like x 1
    17. d'Wooluf

      d'Wooluf Member

      Tinnitus Since:
      2010
      Cause of Tinnitus:
      unknown
      I don't like them particularly either, but I don't feel I really need to. The possibility of things 'going sideways' is just assumed in any clinical trial. They do control the information flow to their advantage. That's to be expected I guess.

      The thing is, they have achieved 'functional improvement'. It would be nice if that improvement were large, but even if it were small, it's still a beginning. I'm not sure why it's not all over the news to be honest.

      I found something on Reddit from a person who was involved in administration for that particular trial. She said it was the best trial she had ever been involved in and Frequency Therapeutics were great people to deal with. Can't find the link at the moment.
       
      • Like Like x 5
      • Informative Informative x 1
      • Optimistic Optimistic x 1
    18. JohnAdams
      Studious

      JohnAdams Member Benefactor Hall of Fame

      Location:
      Nasty Swamp
      Tinnitus Since:
      May 1st 2018
      Cause of Tinnitus:
      Aspirin Toxicity/Possibly Noise
      I've been in contact with some of the people with Frequency Therapeutics as well and they are very open and actively engaged. They have passion about what they are doing for sure. I don't think this is a typical pharmaceutical company at all. They definitely are fully engaged.
       
      • Like Like x 5
      • Agree Agree x 1
      • Optimistic Optimistic x 1
    19. Aleksa Uzunovic

      Aleksa Uzunovic Member

      Tinnitus Since:
      2014
      Cause of Tinnitus:
      Noise induced hearing loss
      Look bruv, I don't give a damn, I'm taking 20 shots of that thing per ear if it works, no big deal.
       
      • Like Like x 4
      • Funny Funny x 1
      • Winner Winner x 1
    20. 85dB T
      Malnourished

      85dB T Member

      Tinnitus Since:
      *
      Cause of Tinnitus:
      *
      Frequency Therapeutics Announces Positive Phase 1/2 Data for Drug Candidate for Hearing Restoration


      Primary safety endpoint met as FX-322 was well tolerated

      Preliminary clinical data suggests improvement on measures of hearing function

      Company now planning Phase 2 Study to commence later this year

      April 09, 2019 07:00 AM Eastern Daylight Time


      'https://www.businesswire.com/news/h...Therapeutics-Announces-Positive-Phase-12-Data
       
      • Like Like x 2
      • Informative Informative x 1
    21. 85dB T
      Malnourished

      85dB T Member

      Tinnitus Since:
      *
      Cause of Tinnitus:
      *
      Conventional experience is only worth so much. They may prefer someone competent, capable and passionate about the opportunity. They can train you their way without retraining inferior skills and techniques.
       
      • Agree Agree x 2
      • Like Like x 1
    22. David Dorci

      David Dorci Member

      Tinnitus Since:
      02/09/19
      Cause of Tinnitus:
      Medication, Depression
      Dear David - thank you for your nice email and sorry to hear about your hearing loss.
      Frequency is working to develop a therapy to combat noise-induced hearing loss in this initial study. While we are still some time away from a commercially available treatment, we are working hard to move as quickly as possible to that outcome. The clinical trials will be conducted in 3 separate stages as explained by the National Institutes of Health, but the overall time frame will be dependent on the trial design. You may find further information on how trials are crafted and conducted here: https://clinicaltrials.gov/ct2/about-studies

      The cause of tinnitus is not clear in all cases, but this condition is almost always accompanied by hearing loss due to damaged cells within the inner ear. Because of this, regenerating hair cells may be helpful in patient suffering from tinnitus.

      Also, in the meantime you can learn about existing clinical studies being performed around the world at the FDA website - here is a link: https://www.clinicaltrials.gov/ct2/results?term=hearing+loss&Search=Search
      Please visit this link and enter your contact info to be part of Frequency’s outreach efforts and keep people informed of our progress: http://frequencytx.com/contact/index.php
      and any questions you have about Frequency’s study should be sent directly to clinicaltrials@frequencytx.com

      With warm regards,
      Jeff
      Jeff Karp B.Eng. PhD.
      Professor of Medicine
      Brigham and Women’s Hospital, Harvard Medical School
       
      • Like Like x 5
      • Winner Winner x 3
      • Informative Informative x 2
    23. Gorbeh3

      Gorbeh3 Member

      Tinnitus Since:
      2012
      Cause of Tinnitus:
      Hearing Loss
      On Friday, I called the number on the website regarding clinical trials and gave them my information, the woman who I was speaking to said I would get an email soon.

      I received the following:
       
      • Like Like x 3
      • Informative Informative x 2
    24. Piney

      Piney Member

      Tinnitus Since:
      March 2018
      Cause of Tinnitus:
      Shingles virus
      I got the same. I wonder if my VA audiologist has to call. It’s probably a long shot.
       
      • Genius Genius x 1
    25. meirzhu15

      meirzhu15 Member

      Tinnitus Since:
      01/10/2018
      Cause of Tinnitus:
      SSNHL
      Only noise induced hearing loss... not my case.
       
    26. Graig

      Graig Member

      Tinnitus Since:
      10/17
      Cause of Tinnitus:
      Sudden Hearing Loss
      I think they have included sudden hearing loss in many of their postings. The last trial included people with hearing loss due to noise exposure or sudden sensorineural hearing loss.
       
      • Like Like x 1
    27. tarmaced
      Wtf

      tarmaced Member

      Tinnitus Since:
      2004 (mild) 2018 (not so mild)
      Cause of Tinnitus:
      Ear infections, compounded by noise exposure
      Same response I got when enquiring about UK clinical trials of FX-322.
       
      • Like Like x 2
    28. hopeful4future

      hopeful4future Member

      Tinnitus Since:
      2013
      Cause of Tinnitus:
      Gun Shot
      So would genetic hearing loss not be included? I’m not sure if mine is noise induced or genetic. I have about the exact same hearing loss in one ear as my mother but perfect hearing in the other ear as she is deaf in the other ear. I never noticed my hearing loss until after firing a gun and tinnitus started, then went to an audiologist and found out about the reverse slope hearing loss which is very identical to my mom's.
       
      • Hug Hug x 2
    29. bell

      bell Member Benefactor

      Tinnitus Since:
      2004
      Is there going to be an UK clinical trial? I am so interested in what you are saying mate!
       
    30. AUTHOR
      AUTHOR
      RB2014
      Confused

      RB2014 Member Benefactor

      Location:
      US
      Tinnitus Since:
      12/2014 became noticable
      Cause of Tinnitus:
      Loss of hearing and then stress and anxiety
      Mine is genetic as well as noise induced so I am in the same boat. I've read a lot and I don't think there is a clear answer. Usually when they exclude genetic hearing loss they mean your ear wasn't built right at birth. Many people just have bad genes, like myself, that makes the hearing loss in the high frequencies go faster. I think the answer is it should work for us just the same, but right now it is not really known.
       
      • Like Like x 1

Share This Page

Loading...