Frequency Therapeutics — Hearing Loss Regeneration

Discussion in 'Research News' started by RB2014, Dec 8, 2016.

    1. GSC
      Wishful

      GSC Member Hall of Fame

      Tinnitus Since:
      02/2019
      Cause of Tinnitus:
      Acoustic trauma.
      @Shelly75

      Hearing aids do not cover the range of hidden hearing loss. Those children could be suffering from hidden hearing loss, or their tinnitus can come from a 5 db dip that is still in the normal range of hearing. Maybe the hair cells aren't damaged enough so they can be salvaged with resting your ears, or nerve repair. Maybe your brain gets use to your new range of hearing, which is why some people's tinnitus fades or goes into remission. Those people who woke up with tinnitus probably broke the camel's back - and will not know, because hidden hearing loss is not tested for.

      Or even smaller cases - TMJ/TMD/ETD/NECK ISSUES etc<-- all other lesser causes that induce tinnitus.
       
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    2. d'Wooluf

      d'Wooluf Member

      Tinnitus Since:
      2010
      Cause of Tinnitus:
      unknown
      Their treatment improved functional hearing for at two people with sudden sensorineural hearing loss. I don't think that's ever been done before. Sounds like a step forward to me.
       
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    3. d'Wooluf

      d'Wooluf Member

      Tinnitus Since:
      2010
      Cause of Tinnitus:
      unknown
      I've brought this up before and didn't get any responses. What happens if all our dreams come true and FX-322 is proved to be a successful treatment for hearing loss? How many people are going to be seeking treatment? Well, millions if it's really that good. How many people are qualified to administer intratympanic injections right now? How much time can they spare from their current duties? What kind of waiting lists would you expect?

      I'm thinking a backup method of treatment that you could train nurses or techs to do might be nice to have.
       
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    4. JohnAdams
      Studious

      JohnAdams Member Benefactor Hall of Fame

      Location:
      Nasty Swamp
      Tinnitus Since:
      May 1st 2018
      Cause of Tinnitus:
      Aspirin Toxicity/Possibly Noise
      The beauty is that the procedure would only take like 30 seconds.
       
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    5. JoNo78

      JoNo78 Member

      Location:
      Kiel, Germany
      Tinnitus Since:
      2019
      Cause of Tinnitus:
      Sudden Hearing Loss
      The IT injection itself is quick to do and doctors have been using this method for years (here in Europe). But it needs time to diffuse the FX-322 through the round window into the cochlea. Maybe 30-60 minutes. But... That's OK if it works! I am really interested what Frequency Therapeutics will publish of the results from the Phase 1 trial.
       
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    6. Aleksa Uzunovic

      Aleksa Uzunovic Member

      Tinnitus Since:
      2014
      Cause of Tinnitus:
      Noise induced hearing loss
      30 seconds means shit if we're going to have to wait for 3 more years.
       
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    7. JoNo78

      JoNo78 Member

      Location:
      Kiel, Germany
      Tinnitus Since:
      2019
      Cause of Tinnitus:
      Sudden Hearing Loss
      3 years? Well... I think 5 years at a minimum... Does anyone know the big conference where Frequency Therapeutics wants to present the results from the phase 1/2 trial?

      And I think that if they say something about audiograms and word scoring it could be remarkable!
       
    8. d'Wooluf

      d'Wooluf Member

      Tinnitus Since:
      2010
      Cause of Tinnitus:
      unknown
      How quick? How much of the doctor's time?

      By 'doctors' you mean general practioners? The same guys you go to for a chest infection or to get your cholesterol checked? I thought it was something that only specialists did.
       
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    9. tarmaced
      Wtf

      tarmaced Member

      Tinnitus Since:
      2004 (mild) 2018 (not so mild)
      Cause of Tinnitus:
      Ear infections, compounded by noise exposure
      There are people on here that have already waited 10+, 20+ years. I think 3 years to go would mean quite a bit to them and should do for others vs. diddly-squat.
       
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    10. JoNo78

      JoNo78 Member

      Location:
      Kiel, Germany
      Tinnitus Since:
      2019
      Cause of Tinnitus:
      Sudden Hearing Loss
      Well... the injection itself takes seconds, then one has to lie down and wait a specific period of time to allow the drug to go into the cochlea. But this can be done while lying outside of the doctor's room, and the doctor can see another patient in the meanwhile.

      And here in Germany the ENT doctors are doing the IT method. How is it in the US?
       
    11. Fabrikat

      Fabrikat Member

      Tinnitus Since:
      1973
      Cause of Tinnitus:
      Otosclerosis then volume then viral infection
      And if Audion is successful in Europe, perhaps four years, considering Europe's speedier approval process.
       
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    12. FGG

      FGG Member Podcast Patron Benefactor

      Tinnitus Since:
      01/2019
      Cause of Tinnitus:
      Multi-factorial
      This might belong in a different thread but if I'm reading this correctly, the phase 2 trial for Audion should be completed by end of December:

      http://www.isrctn.com/ISRCTN59733689
       
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    13. JoNo78

      JoNo78 Member

      Location:
      Kiel, Germany
      Tinnitus Since:
      2019
      Cause of Tinnitus:
      Sudden Hearing Loss
      That would be great!! But do you all really think this time window is realistic?
       
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    14. Fabrikat

      Fabrikat Member

      Tinnitus Since:
      1973
      Cause of Tinnitus:
      Otosclerosis then volume then viral infection
      If they finish Phase 2 by the end of the year, that leaves another three years to get through Phase 3 and the approval process. That's if it's successful and there are no hold ups. That doesn't sound overly ambitious to me. But then again, anything can happen.
       
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    15. JoNo78

      JoNo78 Member

      Location:
      Kiel, Germany
      Tinnitus Since:
      2019
      Cause of Tinnitus:
      Sudden Hearing Loss
      Well... I agree with that. Maybe this is the reason for Frequency Therapeutics to talk about "fast tracking" with the FDA? I mean, the company who is the first to the market will make it big time, or am I wrong?

      Nevertheless it is a very optimistic beginning and maybe (hopefully) we will have the drug available in a couple of years! It is so fascinating, because it's not only about the regeneration of the hair cells itself but also about their connection to the nerves to make it all work.

      What do others here think about it?
       
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    16. d'Wooluf

      d'Wooluf Member

      Tinnitus Since:
      2010
      Cause of Tinnitus:
      unknown
      I'm not in the US, but I guess the same. I'm trying to think myself around how this might work. In Australia, there aren't many medical specialists to go around. Medical specialists are trained by medical specialists, so there's never an oversupply for obvious reasons. If I need to see one, I get a referral from my GP and I usually need to wait for 2 weeks or more for an appointment.

      So, when a treatment for hearing loss becomes available, I get my referral and present at the ENT's "rooms". He/she gets my history, maybe does my audiogram (they might have an audiologist on hand to do it for them), explains the risks and the possible benefits of the it injection. Their consultation rooms don't have beds, so another appointment is made at some sort of treatment facility. That's twenty minutes minimum gone already.

      At the treatment facility I'm going to be taking up at least a few minutes of the ent's time (once he/she says hello, explains what they're about to do), plus there's a nurse to keep an eye on me, plus a bed for an hour. The bed requirement alone limits the number of procedures that could be done each day. Make it ten procedures per day per bed. I don't think there's a great oversupply of hospital beds around here either.

      So, was it 20% of the population with hearing loss? Ok, halve that, and take another 90% off for those who can't afford the treatment or can't be bothered. That's still a huge tsunami of need descending on a health system that's not equipped to deal with it.

      That's why I say don't discount the need for alternative delivery methods. I'd be happy with an it injection myself. If a non-invasive delivery method means I get treatment sooner, I'd be even happier.
       
    17. reggie green
      Balanced

      reggie green Member

      Tinnitus Since:
      03/08/2001
      How much will FX-322 cost?
       
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    18. Daniel Lion
      Ape-like

      Daniel Lion Member Podcast Patron Benefactor Hall of Fame

      Location:
      SE Asia
      Tinnitus Since:
      2017
      Cause of Tinnitus:
      Noise trauma, hearing loss
      Hi reggie green, I am Daniel.

      Let's do a betting poll to see how much it will cost. Let's say insurance will not cover it and it has to be paid out of pocket? How much would a person have to pay?

      Difficult question for somebody with no financial breakdown. I would sacrifice a hand and other bodily parts to restore hearing and be tinnitus free. So considering I'm a low budget operation, I'd love to see the shots, audiograms, checkups, the whole package for 10 to 12 thousand dollars. If it was 6 to 8 thousand dollars I may actually have to become religious. Cheaper is better, they will certainly have millions of customers.

      I predict that in 2022 there will be a wave of "nerd crimes".
      Acts of depravity, bank robberies, cyber crimes all to feed the desperate hordes of hearing loss, hypercusis and tinnitus sufferers trying to get their FX-322 fix.

      Like Breaking Bad times 5 million.

      What do you think reggie green?
      How much for the drug?
      How much for the full service?
       
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    19. JoNo78

      JoNo78 Member

      Location:
      Kiel, Germany
      Tinnitus Since:
      2019
      Cause of Tinnitus:
      Sudden Hearing Loss
      Hello Daniel,

      Do you really think that in 2022 the drug could be on the market? If they pass the clinical trials and the approval process then they need to produce the drug in large quantities... Same with Audion...

      And I would spend money to get my hearing back!!!

      How much it will cost is a good question indeed. I would say that it won't be that much. Let's say around $5000 everything included?
       
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    20. reggie green
      Balanced

      reggie green Member

      Tinnitus Since:
      03/08/2001
      I don't know really.
      $5,000.
      $7,000.
       
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    21. Daniel Lion
      Ape-like

      Daniel Lion Member Podcast Patron Benefactor Hall of Fame

      Location:
      SE Asia
      Tinnitus Since:
      2017
      Cause of Tinnitus:
      Noise trauma, hearing loss
      It's still early days, a lot can go wrong.

      But if we are lucky and the universe gives us a break, 2024 or 2025 would seem most likely. They have to finish phase 2 and 3, and we don't even know how they will pan out.

      If they are awesome, it will take some time for production, and training up doctors with the correct protocol.

      Wish it was tomorrow... Fingers crossed.

      Post note- obviously the earlier the better......come on Frequency ...let's go asap please
       
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    22. reggie green
      Balanced

      reggie green Member

      Tinnitus Since:
      03/08/2001
      2024. That's a long way off.
       
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    23. Daniel Lion
      Ape-like

      Daniel Lion Member Podcast Patron Benefactor Hall of Fame

      Location:
      SE Asia
      Tinnitus Since:
      2017
      Cause of Tinnitus:
      Noise trauma, hearing loss
      I know it's a long way off... and that's if we're lucky. Suffering sucks. What can I say. Let's all be supportive of each other in the mean time, perhaps if we all wrote letters to the FDA and Frequency Therapeutics it might help. A few thousand letters saying please fast track this drug...

      No easy answers my friends, and the drug has yet to complete phase 2. At times like this I would like to have a cigarette, but I quit. Smoking would destress me. I am off to the sauna now, I need to chill.

      Take care all and fingers crossed Frequency Therapeutics keeps kicking ass.
       
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    24. JohnAdams
      Studious

      JohnAdams Member Benefactor Hall of Fame

      Location:
      Nasty Swamp
      Tinnitus Since:
      May 1st 2018
      Cause of Tinnitus:
      Aspirin Toxicity/Possibly Noise
      Hahaha no. They think we're stupid animals.
       
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    25. JoNo78

      JoNo78 Member

      Location:
      Kiel, Germany
      Tinnitus Since:
      2019
      Cause of Tinnitus:
      Sudden Hearing Loss
      Why do you think that?

      And... wouldn't Frequency Therapeutics ask the FDA for fast tracking?
       
    26. KMc24

      KMc24 Member Benefactor

      Tinnitus Since:
      3/2018
      Cause of Tinnitus:
      Noise induced
      If it is successful I can't imagine why the FDA wouldn't fast track it. It would be nothing short of miraculous if it cures tinnitus and hearing loss.
       
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    27. JohnAdams
      Studious

      JohnAdams Member Benefactor Hall of Fame

      Location:
      Nasty Swamp
      Tinnitus Since:
      May 1st 2018
      Cause of Tinnitus:
      Aspirin Toxicity/Possibly Noise
      Well they said they would.
       
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    28. JoNo78

      JoNo78 Member

      Location:
      Kiel, Germany
      Tinnitus Since:
      2019
      Cause of Tinnitus:
      Sudden Hearing Loss
      Well... Speaking for myself it would be fine if it restored hearing. And I think that in this case also tinnitus will reduce when we get back our natural hearing with our own ears!

      What do you think, so they have something on their hands that they will ask to be fast-tracked? It seems that they are sure that it might work what they are developing... Or?
       
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    29. Street Novelist
      Depressed

      Street Novelist Member

      Location:
      Bay Area
      Tinnitus Since:
      February 2018
      Cause of Tinnitus:
      Listening to loud music through headphones
      I think we should wait for the results of the next trial before we start guessing when the drug will be commercially available. Posting far away dates can only make us more depressed. How about just wait and see? It will probably happen sooner rather than later.
       
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    30. KMc24

      KMc24 Member Benefactor

      Tinnitus Since:
      3/2018
      Cause of Tinnitus:
      Noise induced
      I just got back from my appointment with my ENT today. I mentioned FX-322, and she is aware of it. She said that the capability for regeneration already exists, it's just a matter of time. They've got something. Just have to wait for the trials to be completed to find out exactly what...
       
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