Frequency Therapeutics — Hearing Loss Regeneration

Discussion in 'Research News' started by RB2014, Dec 8, 2016.

    1. Telis

      Telis Member Hall of Fame

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      To me personally, a lot.
       
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    2. d'Wooluf

      d'Wooluf Member

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      Look up the resumes of the principals. Is there a chance that it will not work? Yes. Is there a chance of outright fraud? I'd say close to zero.
       
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    3. JohnAdams
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      They already said it worked so wouldn't the chance that it will not work be zero?
       
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    4. JohnAdams
      Murderous

      JohnAdams Member Benefactor Hall of Fame

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    5. Reinier
      Not amused

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    6. JohnAdams
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      JohnAdams Member Benefactor Hall of Fame

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    7. Ivkopivko
      Speechless

      Ivkopivko Member

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      don't know, probably motorsport + headphones for last years
      From such a small trial with non-publicly released results/outcome? I obviously don't understand what's behind but doesn't make a sense as they completed phase of trial with such a low number of participants. (Of course I hope I'm wrong and they and their investors that might be acknowledged with results already sees another breakthrough).
       
    8. JohnAdams
      Murderous

      JohnAdams Member Benefactor Hall of Fame

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      They also have robust in vitro and in vivo evidence that the drug regrows the hair cells and that they reconnect and restore hearing function.
       
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    9. Reinier
      Not amused

      Reinier Member Benefactor

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      But I think there is more to it.
      Don't forget that investors will be able to make more informed decisions to invest or not to invest. Investors will try to find information to make the investment as low risk as is possible. I assume FT will give investors more information than the information they share with non investors.
       
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    10. Mathieulh
      Busy

      Mathieulh Member Benefactor

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      Well, it'd still make sense if you were totally deaf, otherwise I wouldn't risk such an invasive procedure xD
       
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    11. 85dB T
      Malnourished

      85dB T Member

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      @JohnAdams I forgot your opinion. What are the chances that hair cell regrowth will reduce or eliminate tinnitus? Of course we'll wait and see, am just curious.

      I pray this miracle will happen. Don't we all.
       
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    12. zhiyuan
      Depressed

      zhiyuan Member

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      Does anyone know if the loss of hair cells cause damage to the supporting cells?

      FX-322 use supporting cells but if someone's supporting cells get hurt, it means nonsense?

      And it seems like there are different types of hair cells since they sense different frequencies, so FX-322 could regenerate various types of hair cells?
       
    13. ChrisBoyMonkey

      ChrisBoyMonkey Member Podcast Patron

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      I don't think the supporting cells would get hurt from cochlear damage like sound, as they do not react to it like hair cells do. It's like skin cells being able to be damaged by those levels of sound. And yes, those cells should be able to restore any frequency so long as they are hair cells.

      Perhaps that's how they came up with their name...
       
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    14. Mathieulh
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      Mathieulh Member Benefactor

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      They can still get damaged from pathogens or ototoxic medications though. Sound however indeed wouldn't damage those.
       
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    15. PolishSoldier87
      Moonlighting

      PolishSoldier87 Member

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      I wonder if FX-322 doesn't damage the order of the hair cells. Playing with notch signaling can lead to unexpected proliferation of hair cells. Anyone know something about this?

      B - acceptable? What do you think?

      ffoojtv-png.png
      uz5jbbs-png.png

      A - No treatment
      B - Atoh1 over-expression
      C - g-secretase inhibitor in the Notch signal pathway
      D - Atoh1 over-expression + g-secretase inhibitor
       
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    16. Fabrikat

      Fabrikat Member

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      So do you think that FX-322 would not be able to regrow hair cells, where they have been damaged by virus or ototoxic medications?
       
    17. streeter1985
      Studious

      streeter1985 Member Benefactor

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      I already mentioned the hyperlink, if you are interested in it you can read it: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3637947/

      In summary if you have severe to profound hearing loss there could be a flat epithelium in the cochlea. The huge damage forms scars and can also eliminate Pillar and Deiter cells which in my opinion are very important concerning the right alignment of the new grown hair cells. It seems that there is a lack of supporting cells in that flat epithelium. So we can only hope that their approach also eliminates that problem. Only time can tell... if the sequence allows your body to automatically differentiate between the location of damage and the formation between Pillar and Deiter cells and the right position for regrowing hair cells everything is fine :)

      The flat epithelium only takes 1 week to be formed from your body after damage. If humans would be able to regrow hair cells (by nature) right after damage maybe that process would have been stopped... but thats just an idea.

      Well that's how I understand that manuscript...
       
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    18. Mathieulh
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      Mathieulh Member Benefactor

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      I don't know, it would take clinical trials to find out.
       
    19. PolishSoldier87
      Moonlighting

      PolishSoldier87 Member

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      It's probable that they can be regrown, unless pillar and phalangeal cells are destroyed.
      Anatomy-of-the-cochlea-A-The-overall-structure-of-the-inner-including-vestibular.jpg

      On the other hand I found a view where proliferation of supporting cells also happens.
      Conceptual-drawings-of-the-normal-damaged-and-repaired-organ-of-Cortia-In-the-normal.jpg
       
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    20. zhiyuan
      Depressed

      zhiyuan Member

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      That's sad. So when FX-322 comes, we all have some flat epithelium that may decrease the effect.
       
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    21. zhiyuan
      Depressed

      zhiyuan Member

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      Here is the publication from Frequency Therapeutics:

      http://dx.doi.org/10.1016/j.celrep.2017.01.066.

      I just had a quick read and think the paper says they can expand the number of positive supporting cells. So maybe even if you have some injury to your supporting cells, the drug can still work.
       
    22. JohnAdams
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      JohnAdams Member Benefactor Hall of Fame

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      Well, if the loss of hair cells is what has caused your tinnitus then I think it will help. If there is damage to nerves in other parts of the system that is causing hyperactivity then I don't see how this could work unless there is some kind of healing cascade effect.
       
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    23. streeter1985
      Studious

      streeter1985 Member Benefactor

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      That depends on the individual situation of the cochlea after the damage - not everyone has severe to profound hearing loss. We have to wait until we know more and get some data from the trial. Maybe the power of the human body itself can solve some problems when FX-322 starts the sequence in the supporting cells like the miracle that nerves connect to the regrown hair cells etc. We also don't know anything about the quality (hearing) of regrown hair cells. I think the flat epithelium is only mentioned in connection with severe to profound hearing loss.

      My personal opinion is that we are allowed to put hope into this approach. The idea behind FX-322 is great and the investments and co-operations also look very very promising.
       
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    24. Daniel Lion
      Ape-like

      Daniel Lion Member Benefactor

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      “allowed to put hope into this approach”

      Amen to that...

      Lots of hope and faith for better days, and better hearing.

      Speed it up Frequency Therapeutics, bring it on, you got your cash...
      Let’s get the next trial started...

      Sincerely, Daniel
       
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    25. Enclave

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      In the 2nd diagram, what year was this created? Where is the literature you pulled this from?

      I’m curious, did the verbiage mention what happens to the Tunnel of Corti between B and C in this diagram?
       
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    26. Chriscom

      Chriscom Member Benefactor

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      Hearing aids apparently help reduce tinnitus in some people, judging from what I've read around the web and heard from my audiologist and ENT.
       
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    27. BrStan@

      BrStan@ Member

      Location:
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      Hearing aids reduce tinnitus by acting like maskers.
       
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    28. ChrisBoyMonkey

      ChrisBoyMonkey Member Podcast Patron

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      I have a coworker whose use of hearing aids stopped his tinnitus, even when he's not using them.
       
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    29. Daniel Lion
      Ape-like

      Daniel Lion Member Benefactor

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      That’s amazing.
      First I ever heard of that.
      Maybe that could happen for a few of us... wouldn’t that be a miracle.

      Take care Monkey.
       
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    30. 85dB T
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      85dB T Member

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      Were the hearing aids simply providing amplification or were they programmed a certain way to help tinnitus? (supposedly).

      Instead of purchasing $3000 to $6000 hearing aids (prescribed by audiologist), I've been told many people are buying amplifiers like these at Bass Pro Shop for $150:

      https://www.basspro.com/shop/en/gam...&pageView:grid&minPrice:&maxPrice:&pageSize:&
       

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