Frequency Therapeutics — Hearing Loss Regeneration

Discussion in 'Research News' started by RB2014, Dec 8, 2016.

    1. Misticvega

      Misticvega Member

      Tinnitus Since:
      2018
      Cause of Tinnitus:
      Probably noise exposure?
      This. I think phase 3 is necessary to determine the maximum efficacy. What happens if we give this dude more? What if he comes back a 2nd or 3rd time? Does the patient with more hearing loss need more or is it all the same - once the process starts it's a chain reaction? How long until the hearing is restored? Does ones environment after the procedure affect results?

      Phase 3 is big-time. If we can get through this, we may be close.
       
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    2. JohnAdams
      Murderous

      JohnAdams Member Benefactor Hall of Fame

      Location:
      here
      Tinnitus Since:
      it started.
      Cause of Tinnitus:
      hearing loss
      All these questions could be answered with a phase 3 open trial, where they start offering it to the public and that's what I think will happen.

      Also, let's not get too hyped about this. Will McLean seems to have indicated his belief that restoring hearing will treat tinnitus, and I think that is true as well, but for some or many of us, this is not simply the case. If we have disregulated nerve synapses then this might not do anything for us, unless the disregulated synapses are staying disregulated because of the loss of input from lost hair cells, which might be the case. One thing I don't believe is that tinnitus starts in the brain unless you have a brain injury.
       
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    3. Misticvega

      Misticvega Member

      Tinnitus Since:
      2018
      Cause of Tinnitus:
      Probably noise exposure?
      Do you mean that the nerve synapses themselves have been damaged too, in addition to the loss of hair cells?
       
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    4. JohnAdams
      Murderous

      JohnAdams Member Benefactor Hall of Fame

      Location:
      here
      Tinnitus Since:
      it started.
      Cause of Tinnitus:
      hearing loss
      Yes.
       
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    5. Earing
      No Mood

      Earing Member

      Tinnitus Since:
      2010
      Cause of Tinnitus:
      noise
      As positive as this might be, and I am really hoping it is successful, there could be downsides. What if when the hair cells grow back tinnitus gets 10 x louder? What if some people get tumors? What if...?

      Caution must be exercised despite our need for a solution. I would wait for a completed phase 3. As I understand it, phase 1 is a very small sample of people who get a really small dose to see if it has negative effects. If phase one doesn't kill or maim anyone, they go to phase 2. Phase 2 is also only testing for negative effects using a larger test group. If phase 2 also doesn't kill or maim, then they go on to phase 3. Phase 3 is the only phase that tests to see if the drug actually works. So skipping phase 3 may not be in our best interests.

      I am not as knowledgeable about this stuff as others here, but this was what I read some time ago about a different drug trial I was following.
       
      • Agree Agree x 1
    6. Rb86

      Rb86 Member

      Tinnitus Since:
      5/31/19
      Cause of Tinnitus:
      Noise
      I believe it was noted in phase 1 that they already experienced positive results in hearing regeneration.

      Also, let's just be real here, multi millions of dollars just jumped on board here recently, so I think they feel very strongly about their chances here.
       
    7. d'Wooluf

      d'Wooluf Member

      Tinnitus Since:
      2010
      Cause of Tinnitus:
      unknown
      • Like Like x 1
    8. JohnAdams
      Murderous

      JohnAdams Member Benefactor Hall of Fame

      Location:
      here
      Tinnitus Since:
      it started.
      Cause of Tinnitus:
      hearing loss
      It won't.
      ¯\_(ツ)_/¯

      Bah humbug.
       
    9. Earing
      No Mood

      Earing Member

      Tinnitus Since:
      2010
      Cause of Tinnitus:
      noise
      It could be spin.
       
    10. Rb86

      Rb86 Member

      Tinnitus Since:
      5/31/19
      Cause of Tinnitus:
      Noise
      What do you mean?
       
    11. ajc

      ajc Member

      Tinnitus Since:
      11/2002; spike 2009; worse 2017-18
      Cause of Tinnitus:
      Loud music - noise damage
      • Agree Agree x 1
    12. Earing
      No Mood

      Earing Member

      Tinnitus Since:
      2010
      Cause of Tinnitus:
      noise
    13. Rb86

      Rb86 Member

      Tinnitus Since:
      5/31/19
      Cause of Tinnitus:
      Noise
      Yes, but, the articles you provide talk about Alzheimer's research and drugs to cure that, as well as other brain diseases. Then the trial they discontinued was for a separate and rare brain disease they were also hoping to cure.

      Similarly, Frequency Therapeutics is targeting mechanisms that could help aid a wide array of diseases, but the main focus is currently tinnitus.

      Everything is speculation at this point.

      What speaks to me is that they ran the first trial, and all the sudden a lot of additional money came out of the woodwork. I think investors had access to phase 1 results and now they really want to join.

      Apparently we'll be let in on the results in a month or two.
       
    14. Earing
      No Mood

      Earing Member

      Tinnitus Since:
      2010
      Cause of Tinnitus:
      noise
      I thought it was on hearing loss?
       
    15. ChrisBoyMonkey

      ChrisBoyMonkey Member Podcast Patron

      Location:
      CA
      Tinnitus Since:
      04/2019
      Cause of Tinnitus:
      U.S. Army/Field Artillery Veteran / loud computer
      Just for clarification, the main thing they are trying to treat is hearing loss, not tinnitus.

      The hope for us is that tinnitus will be treated as a result of treating hearing loss, but that is not their main objective.

      It is true that a lot of money and new partners coming in doesn't guarantee that it will work, but it sure is a great sign that it probably will.

      Now if it cures our tinnitus is another story, we just don't know for sure. I really hope it will, but no one knows for certain. Logic says it should help, as most of the science community agrees. But what is almost certain, if it does work, it'll help those that are currently ineligible for treatments like Lenire become eligible by having their hearing restored.
       
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    16. Rb86

      Rb86 Member

      Tinnitus Since:
      5/31/19
      Cause of Tinnitus:
      Noise
      My mistake... "Hearing loss".

      Again, at any rate, this entire conversation is speculatory until we cross the next milestones, therefore I'll bow out.

      The ball is in our court though.
       
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    17. tarmaced
      Wtf

      tarmaced Member

      Tinnitus Since:
      2004 (mild) 2018 (not so mild)
      Cause of Tinnitus:
      Ear infections, compounded by noise exposure
      47 days!
       
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    18. Stefaniie

      Stefaniie Member

      Tinnitus Since:
      2017
      Cause of Tinnitus:
      Hereditary hearing loss/noise exposure
      Even if it does not cure the tinnitus, at least I will have better hearing! Which will do wonders in masking my tinnitus.

      And like @ChrisBoyMonkey said, those of us who aren't eligible to use Lenire because of hearing loss will be able to get the treatment in the future. I pray this drug is successful and that it comes out quickly.
       
      Last edited by a moderator: Aug 2, 2019
      • Agree Agree x 4
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    19. JohnAdams
      Murderous

      JohnAdams Member Benefactor Hall of Fame

      Location:
      here
      Tinnitus Since:
      it started.
      Cause of Tinnitus:
      hearing loss
      They have already said it worked.
       
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    20. JohnAdams
      Murderous

      JohnAdams Member Benefactor Hall of Fame

      Location:
      here
      Tinnitus Since:
      it started.
      Cause of Tinnitus:
      hearing loss
      • Good Question Good Question x 1
    21. JohnAdams
      Murderous

      JohnAdams Member Benefactor Hall of Fame

      Location:
      here
      Tinnitus Since:
      it started.
      Cause of Tinnitus:
      hearing loss
    22. Piney

      Piney Member

      Tinnitus Since:
      March 2018
      Cause of Tinnitus:
      Shingles virus
    23. Misticvega

      Misticvega Member

      Tinnitus Since:
      2018
      Cause of Tinnitus:
      Probably noise exposure?
      What makes you think there is a chance nerve synapses would be damaged as well?

      Are damaged nerve synapses a potential cause of hyperacusis?
       
    24. JohnAdams
      Murderous

      JohnAdams Member Benefactor Hall of Fame

      Location:
      here
      Tinnitus Since:
      it started.
      Cause of Tinnitus:
      hearing loss
      • Genius Genius x 2
    25. JohnAdams
      Murderous

      JohnAdams Member Benefactor Hall of Fame

      Location:
      here
      Tinnitus Since:
      it started.
      Cause of Tinnitus:
      hearing loss
      Probably.
       
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    26. Contrast

      Contrast Member Benefactor Hall of Fame

      Location:
      Retrovile
      Tinnitus Since:
      late 2017
      Cause of Tinnitus:
      injury from noxious noise
      The reality is we don't know when there becomes too little supporting cells for this to work. But they suggest moderate hearing loss is the limit to FX-322's effective. Noise damages so many different things in the cochlea not just hair cells.
       
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    27. JohnAdams
      Murderous

      JohnAdams Member Benefactor Hall of Fame

      Location:
      here
      Tinnitus Since:
      it started.
      Cause of Tinnitus:
      hearing loss
      Sauce?
       
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    28. Contrast

      Contrast Member Benefactor Hall of Fame

      Location:
      Retrovile
      Tinnitus Since:
      late 2017
      Cause of Tinnitus:
      injury from noxious noise
    29. Rb86

      Rb86 Member

      Tinnitus Since:
      5/31/19
      Cause of Tinnitus:
      Noise
      Huh?
       
    30. Stefaniie

      Stefaniie Member

      Tinnitus Since:
      2017
      Cause of Tinnitus:
      Hereditary hearing loss/noise exposure
      Oh, that's perfect. I have progressive hereditary hearing loss so by the time this comes out I probably won't have enough hearing for Frequency Therapeutics, either. Looks like both my tinnitus and hearing loss are here to stay :(. Nothing quite like having a whole bunch of new treatments for tinnitus for the first time ever, only to not be eligible for literally any of them. Staying optimistic is getting harder and harder...
       
      Last edited by a moderator: Aug 3, 2019

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