Frequency Therapeutics — Hearing Loss Regeneration

Discussion in 'Research News' started by RB2014, Dec 8, 2016.

    1. Chriscom

      Chriscom Member Benefactor

      Location:
      Northern Virginia USA
      Tinnitus Since:
      May 2019
      Cause of Tinnitus:
      Likely infection/ear stress after walking pneumonia
      I don't want to claim more knowledge than I have, since I'm new to all this. But this doesn't surprise me.

      Part of the reduction in tinnitus as others have stated is the result of masking and distraction. You're hearing things through that ear or ears that weren't heard before, so the brain is busy processing that and it pushes tinnitus to the background.

      But based on what I've read, the evidence suggests it can also reduce tinnitus because now that sound is getting piped in again, the brain isn't sending the compensatory transmissions that started when the ear got shut down in the first place.

      Because everyone's ears and brains are different there sure doesn't seem to be any way to predict if and when this will happen to an individual, but this is not the only time I've seen a report like this.
       
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    2. JohnAdams
      Murderous

      JohnAdams Member Benefactor Hall of Fame

      Location:
      here
      Tinnitus Since:
      it started.
      Cause of Tinnitus:
      hearing loss
      Are you sure that's what's happening?
      they are?
       
    3. Mr Mister

      Mr Mister Member

      Tinnitus Since:
      1996
      Cause of Tinnitus:
      Hearing loss, loud music
      This is a bit off topic but it would be great to get similar imaging as above done on your own hearing hair cells.

      Does anyone know if that is possible? Then you could get confirmation that the problem is missing hair cells and maybe even find out which exact frequencies are gone instead of every 1000 Hz or so in a standard audiogram. Everything is imaged these days e.g. cancer tumors, calcium in heart, etc and hearing loss seems to be lagging behind here as well.
       
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    4. JohnAdams
      Murderous

      JohnAdams Member Benefactor Hall of Fame

      Location:
      here
      Tinnitus Since:
      it started.
      Cause of Tinnitus:
      hearing loss
      Completely impossible.

      Those images are from extracted and dissected cochleas and imaged with electron microscopes. The cochlear organ is located in your skull in a very hard bony structure. I think it is the hardest bone in the body.
       
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    5. ChrisBoyMonkey

      ChrisBoyMonkey Member Podcast Patron

      Location:
      CA
      Tinnitus Since:
      04/2019
      Cause of Tinnitus:
      U.S. Army/Field Artillery Veteran / loud computer
      I think they were full on regular hearing aids. I've read online in other places it can do that for some people too.
       
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    6. FGG

      FGG Member

      Tinnitus Since:
      01/2019
      Cause of Tinnitus:
      Meniere's
      We are getting closer to this, I think.

      https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3064988/
       
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    7. FGG

      FGG Member

      Tinnitus Since:
      01/2019
      Cause of Tinnitus:
      Meniere's
      If you go to YouTube and search for Hearing Test HD, you can see where your frequencies drop yourself. They increase numerically one by one instead of every 1000 Hz.
       
    8. JohnAdams
      Murderous

      JohnAdams Member Benefactor Hall of Fame

      Location:
      here
      Tinnitus Since:
      it started.
      Cause of Tinnitus:
      hearing loss
      veen if they could get an electron microscope on the end of an endoscope, there would still be no way to see the hair cells. The endoscope would have to penetrate the round window, or a hole would have to be drilled in the cochlea. Imaging hair cells in the cochlea of a living organism is Start Trek level stuff that is nowhere close to existing. Just look how big they are right now.

      The Scanning Electron Microscope
       
    9. FGG

      FGG Member

      Tinnitus Since:
      01/2019
      Cause of Tinnitus:
      Meniere's
      Dr. Schnitzer at Stanford seems to working on one with a tip so small and flexible that it fits through the round window.

      The gerbil studies are attempting to correlate hair cell morphology and other inner ear pathologies with the lesions and other fibrotic changes seen with the microendoscopy. With a high correlation, this would give otologist a very good estimate of what they would likely look like with electric microscope. It's pretty awesome research and may eventually allow this kind of in vivo diagnostics. It's not perfect but would provide infinitely more individual diagnostic ability than we have now.
       
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    10. GregCA
      Jaded

      GregCA Member Benefactor Hall of Fame

      Tinnitus Since:
      03/2016
      Cause of Tinnitus:
      Otosclerosis
      It is.

      The other fun fact is that the ossicle in contact with the cochlea (called "the stapes") is the smallest bone in the body.

      Otosclerosis is essentially the fact that this bony structure that is supposed to be hard and not undergo any remodeling, well, does undergo remodeling (like our other bones constantly do), leading to a "mushy" contact between the stapes and the cochlea, which itself is the root cause for the conductive losses.

      When things go bad - like in my case, lucky me - the actual bone remodeling process also releases enzymes into the cochlea that are toxic to the hair cells, killing them. That's why I had both conductive and sensorineural losses due to otosclerosis. I "fixed" the conductive losses via surgery, but as we all know well, there's nothing to be done for the sensorineural losses at the moment.
       
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    11. JohnAdams
      Murderous

      JohnAdams Member Benefactor Hall of Fame

      Location:
      here
      Tinnitus Since:
      it started.
      Cause of Tinnitus:
      hearing loss
      And penetrates the membrane?
       
    12. FGG

      FGG Member

      Tinnitus Since:
      01/2019
      Cause of Tinnitus:
      Meniere's
      Seems to be implied, yes.
       
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    13. JohnAdams
      Murderous

      JohnAdams Member Benefactor Hall of Fame

      Location:
      here
      Tinnitus Since:
      it started.
      Cause of Tinnitus:
      hearing loss
      That's a tiny camera then. But you do realize how small the hair cells are right? To image them you pretty much need an electron microscope. Right?
       
      • Good Question Good Question x 1
    14. FGG

      FGG Member

      Tinnitus Since:
      01/2019
      Cause of Tinnitus:
      Meniere's
      Right. That's why the gerbil studies are attempting to correlate the appearance and pattern of lesions found in the cochlea in real time to what they find after gerbil necropsy with an electron microscope.
       
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    15. JohnAdams
      Murderous

      JohnAdams Member Benefactor Hall of Fame

      Location:
      here
      Tinnitus Since:
      it started.
      Cause of Tinnitus:
      hearing loss
      I thought that study was talking about electrode placement in cochlear implants, sorry I just barely glanced at it. Is that the case?
       
    16. FGG

      FGG Member

      Tinnitus Since:
      01/2019
      Cause of Tinnitus:
      Meniere's
      It was about electrode placement. That's the immediate use for it.

      For the microendoscope to be used diagnostically, there
      is ongoing research ultimately aimed at correlating the microendoscope imaging in the cochlea with likely electron microscopy findings (gerbil necropsy studies).

      I posted the article with the cochlear implant just to show that they already have microendoscopes that fit into the cochlea through the round window.
       
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    17. Candy

      Candy Member Benefactor Advocate

      Tinnitus Since:
      06/2016
      Cause of Tinnitus:
      Unidentified
      When a diagnostic tool exists we’ll find out that we have slight damage to some hairs and so does most of the populations with some hearing loss and no tinnitus...?
      Wouldn’t a diagnostic tool analysing brain hyperactivity be more useful?

      Don’t think the hearing loss route will help us.
      Of course great for those with significant hearing loss for whom tinnitus sounds louder than it would otherwise...
       
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    18. JohnAdams
      Murderous

      JohnAdams Member Benefactor Hall of Fame

      Location:
      here
      Tinnitus Since:
      it started.
      Cause of Tinnitus:
      hearing loss
      Not if the hyperactivity originates in the cochlea, auditory nerve, or the DCN. I'm very confident that tinnitus doesn't originate in the brain unless you have had a brain injury.
       
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    19. BrStan@

      BrStan@ Member

      Location:
      London
      Tinnitus Since:
      1999
      Cause of Tinnitus:
      Acoustic trauma
      I can't say the same thing for me though..
       
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    20. ChrisBoyMonkey

      ChrisBoyMonkey Member Podcast Patron

      Location:
      CA
      Tinnitus Since:
      04/2019
      Cause of Tinnitus:
      U.S. Army/Field Artillery Veteran / loud computer
      Unfortunately, it is true that it doesn't happen for everyone. My hearing is normal so I can't even try that route. I will be trying Lenire though! That and anything else that may come up for treatment.
       
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    21. JohnAdams
      Murderous

      JohnAdams Member Benefactor Hall of Fame

      Location:
      here
      Tinnitus Since:
      it started.
      Cause of Tinnitus:
      hearing loss
      Really??????????

      I've never heard that. Very interesting. Tinnitus. What a mysterious beast.
       
    22. BrStan@

      BrStan@ Member

      Location:
      London
      Tinnitus Since:
      1999
      Cause of Tinnitus:
      Acoustic trauma
      Yes my tinnitus is very reactive and when I use my hearing aids the tinnitus seems to be trying to be on the top of any sound. Very weird, it is hard to even explain it. I have high frequency hearing loss, it starts at 4 kHz all the way to 8 kHz. The biggest gap is at 8 kHz - 70 dB hearing loss. One will assume that I can benefit from hearing aids but unfortunately that is not the case.
       
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    23. SergioN

      SergioN Member

      Tinnitus Since:
      25/07/2005
      Cause of Tinnitus:
      Acoustic trauma + ototoxicity
      Will FX-322 help with ear damage caused by barotrauma? I think my tinnitus worsened yesterday due to pressing my tragus too quick and too vehemently because one loud sound surprised me. It was a reflex movement. I'm regretting it and hoping it will improve in time.

      Thanks.
       
      • Good Question Good Question x 2
    24. Mr Mister

      Mr Mister Member

      Tinnitus Since:
      1996
      Cause of Tinnitus:
      Hearing loss, loud music
      If there is a will there's a way. We got nuclear submarines and a man on the moon... It is a question of resource allocation.
       
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    25. jeff W

      jeff W Member

      Location:
      nakatomi plaza
      Tinnitus Since:
      04/2012
      Your post is self explanatory, you wouldn't be on this thread if you didn't take it seriously as a possible solution to hearing loss, hence the thread name:
      Frequency Therapeutics — Hearing Loss Regeneration
      There are plenty of threads on magic pills and neuroplasticity that can reportedly ease the perception of tinnitus.
       
    26. zhiyuan
      Depressed

      zhiyuan Member

      Location:
      China
      Tinnitus Since:
      03/2019
      Cause of Tinnitus:
      sudden hearing loss
      I find that generally the aim of a phase 3 trial is to compare the effects of a new drug with a present most useful drug. Since currently there exists no drug for hearing loss, so if phase 2 is successful, could FX-322 skip phase 3?
       
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    27. AfroSnowman
      Balanced

      AfroSnowman Member Benefactor

      Tinnitus Since:
      April 16 2019
      Cause of Tinnitus:
      Unknown
      Zhiyuan,

      I'm new to all this and I love the idea that they could go from phase 2 straight to public launch. Have you seen an example of this happening?

      The clinicalstudy.gov site described stage 3 as "A phase of research to describe clinical trials that gather more information about a drug's safety and effectiveness by studying different populations and different dosages and by using the drug in combination with other drugs. These studies typically involve more participants."

      I guess I took this to mean checking for interactions with common drugs, fine tuning dosages, developing protocols for maximum efficacy, and testing in a genetically/demographically diffuse group to make sure nothing weird popped up in certain sub groups.
       
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    28. Stefaniie

      Stefaniie Member

      Tinnitus Since:
      2017
      Cause of Tinnitus:
      Hereditary hearing loss/noise exposure
      Hi all.

      Would FX-322 be effective in treating hearing loss caused by Meniere's as well?
       
      • Good Question Good Question x 2
    29. tarmaced
      Wtf

      tarmaced Member

      Tinnitus Since:
      2004 (mild) 2018 (not so mild)
      Cause of Tinnitus:
      Ear infections, compounded by noise exposure
      https://www.forbes.com/sites/aroy/2...-after-phase-ii-a-response-to-matthew-herper/

      See the above link for the description of the 'conditional approval process'. This does happen.

      This might also be referred to as rolling review.

      Also see the link below to confirm that this has also happened 30 times in the EU:
      https://www.bmj.com/content/357/bmj.j2062
       
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    30. zhiyuan
      Depressed

      zhiyuan Member

      Location:
      China
      Tinnitus Since:
      03/2019
      Cause of Tinnitus:
      sudden hearing loss
      Sorry it's just my guess. Your reply may answer my question. Comparison is only one of the aims in phase 3. So they may not skip it.
       
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