Frequency Therapeutics — Hearing Loss Regeneration

Hi folks, it would be nice if someone would summarize the updates about Frequency Therapeutics — Hearing Loss Regeneration in a separate thread.

 

Hello, David007.
I'm new here. Where or how do I find where a new separate thread would be? Is not this the thread being used for updates or are there others?

 

The moderators don't want multiple threads for the same topic and will close the new one down if we add another one. If there is something specific you are looking for try doing a search. We try to keep the threads on topic to make them easier for people to find information. thanks.

 

the xenforo's forums search feature has flaws. I can search for an exact keyword I posted and not find it sometimes.

 

Has anybody here been accepted into the San Antonio trials? If so, please PM me!

 

http://frequencytx.com/news-events/news-events-press-release-08-14-2018.php

Frequency has added additional scientists to their regenerative medicine board.

 

Big time leading scientists.

 

Hi Jake,
Yes this thread used for updates, but also for discussions.

Ok, but 90%+ of this thread is discussions and it's little difficult to see "pure" updates information, especially for those with ADHD/ADD.

 

Your best bet is to Google "Frequency Therapeutics."

 

@David077 most things here are discussions and interpretations of official news/announcements of Frequency Therapeutics. Dont get me wrong but concerning interpretations/bias/hopes from other users (I of course include myself here) a summary of one person might not be helpful to you or deliver you the correct/current content and view on the whole situation.

So I think you should look up some official news about the company itself and then come back and track that thread for a while and you will see that most things are not for 100% set in stone and that many questions will be discussed a few times. Thats what I did a few months ago.

 

https://www.in-pharmatechnologist.c...nitor-cell-activation-for-hearing-restoration

Carl LeBel of Frequency discusses the design of the current trial in an interview.

 

You can't even copy-paste from that article. Never seen that before. He says in a roundabout sort of way that they will be measuring hearing but hearing improvement is not a goal of the study. I take that to mean that they can keep those results to themselves. Commercial reasons probably. I've kind of decided that- brilliant though they may be- I don't like these people very much.

 

Just saw that the Co-founder of Frequency Therapeutics about tinnitus and hearing loss on Reddit today:

 

Frequency Therapeutics' researcher "most likely" William McLean on Reddit stated that cochlear hair cell regeneration should reduce tinnitus if tinnitus is related to hair cell death. This is exciting!

 

Sounds like common sense to me.

 

I know right, but the ATA never publicly suggested cochlear hair cell regeneration
but nor have they said anything against it.

 

I think more illuminating are his quotes regarding the link between high frequency hearing loss undetected by standard hearing tests and tinnitus.

 

the same thing i do, annoy people on the forum by telling them there ENT is wrong about hearing loss.

 

Because people are taught to believe that they are stupid and only people with degrees and badges of authority are allowed to use their minds. Of course this is a dumbass lie. This is nothing new. This is how the powers that be have always controlled people's minds.

 

I don't have that mindset, nor encourage it. I would be more then happy if an actual phD researcher came here and corrected my errors. (speculation, early on post I made, and things I misunderstood,over simplified or outright got wrong)

I'm a college drop out suffering from hearing problems and actual mental problems, I'm not a researcher, PHD

I'm just curious to what the mechanism of tinnitus are and I am trying to understand them, I do not hold any believes or even hypothesis about the mechanism's of tinnitus that haven't already been suggested by actual researchers and whenever I make a post about research I link the source.

I know I get a bit edgy about Auris Medical's semi-peripheral tinnitus model which I believe is wrong and my frustration that hidden hearing loss being ignored by ENT's, I'm just hoping in the long run this website has researchers updating us on discoveries and a faq section which mechanisms of tinnitus, hyperacusis, hearing loss, vestibular issues are broke down into laymens terms. So everyone and myself can have a clearer picture.

I just can't stand it when we get post like "nobody knows anything about tinnitus and a treatment is 100 years away BS" that's probably not the case.Some of the community is more pessimistic then actual researchers are.

 

I personally believe the cause of tinnitus for the majority of people is hearing loss due to damage to the inner ear hair cells. Regrow those, get your hearing completely recovered, and the tinnitus should go away.

 

hello. i've gone back a few pages and also done some other internet research and this seems like a reputable company with intelligent people behind it doing positive things which should make people hopeful. but the tone of this thread seems...i dunno...melancholy? am i missing something or did the thread just get a bit derailed at some point?

 

I think hope is not good enough for some people, especially when they feel that they are at the end of their tether. They're looking for certainty, and they can't find it in a drug which is still in early stage clinical trial. So they keep poring over the tea leaves, analysing every bit of news. It probably gets fatiguing after a while, and morale starts to slide.

I don't know if some of what I say comes across as melancholy. Maybe. Anyway, I was told by an ENT many years ago that there would never ever be a cure for sensironeural hearing loss, so learn lip-reading and get used to it (not as bluntly as that, but close). So it's still amazing to me that we are where we are right now. It's given me some hope for sure.

 

I could be wrong for sure. But I have hope that something will come soon.

 

I wouldnt go by what these ENT´s claim. I met many of them and they seem clueless about inner ear research knowledge.

 

I've also spoken with a couple of ENTs and I told them about FrequencyTx and they had no knowledge of them or what they are doing. One of them even seemed to scoff at the notion. I would think that these people would be staying abreast of current technology. They seem more like salesmen than physicians that are seeking cures. Just like so called teachers that are just there to deliver information and administer standardized tests instead of trying to connect with their students and help bridge the gaps to knowledge.

 

Cant wait for this to come out so this hell can stop. Torture 24/7.

 

He says it should reduce. Aka "maybe it will be better". He doesn't say anything new and he sounds like he doesn't know more about tinnitus than we do.

In his post he says he has his own thinking = theory about what tinnitus is. Again noone understands truly that thing in 2018.

Moreover, most of us are convinced their T is due to hair cell destruction following an audio trauma. Well, this is my case, but I have read a lot about the whole audio circuit from ear to brain and I am also convinced that the majority of people on earth also have hearing loss, even sudden one during concerts, and they don't have tinnitus, so T is not only due to hair cells loss otherwise everyone would have a tinnitus. There is something wrong somewhere else for us, like in the limbic system (part of the frontal lobe of the brain). Regrowing the hair cells will certainly help having our T smaller but there may be a better place to focus to fix the issue and resolve the whole thing.

Again, I think everyone here should at least take 18 minutes to listen to this TEDx video to understand further why tinnitus is more complex than simple "hair cell death":

Tinnitus: Ringing in the Brain | Josef...

It is certainly the most interesting video about tinnitus in 10 years.

edit: erf, I don't want to "spam" with an embedded video, I just wanted to post a link but I can't find a way to simply leave a link without the forum to insert the video.

 

Dr. Robert Aaron Levine's Tinnitus Tutorial
"This narrated presentation explains our current understanding about:

1. why the 2 major causes of tinnitus are hearing loss and problems with the muscles of the head and neck
2. why hearing loss and problems with the muscles of the head and neck sometimes DO and sometimes DO NOT cause tinnitus, and
3. treatments, proven by well-designed studies, are suggested based upon our theory"

„We have decreased activity in the cochlear, that results in decreased activity in the auditory nerve and that results in decreased activity in the Ventral Cochlear Nucleus. But paradoxically the Dorsal Cochlear Nucleus develops increased activity due to the decreased activity coming in from the auditory nerve.“
So maybe treating hearing loss could actually treat one of the causes of tinnitus (if someone's tinnitus is also due to hearing loss). Increasing GABA could also help to suppress tinnitus but that would treat the symptoms rather than the cause. No need to suppress the hyperactivity within the brain with GABA if you can treat the cause of the hyperactivity. But I personally don't need a cure, I'd welcome any reduction in volume.

 

Then how do you explain that most people with hear loss don’t have tinnitus?

Repairing the ear is one fix possibility but it remains a temporary trick until you lose ear cells again.

The real source of the problem remains somewhere else.