Frequency Therapeutics — Hearing Loss Regeneration

Watch the video, it explains a theory as to why not everyone with hearing loss develops tinnitus but 90% of people with tinnitus have hearing loss. From what I’ve read 20-40% of people with hearing loss also have tinnitus.

 

Guys. Is there anywhere else you can take this stuff? This is the Frequency Therapeutics thread.

 

Lessons learned: How Jeff Karp stays at the forefront of innovation

https://www.massdevice.com/lessons-learned-how-jeff-karp-stays-at-the-forefront-of-innovation/

 

Is there any chance that this will restore our super ultra high pitched hearing? My goal is to get my hearing up to 18000 hertz in both ears.

 

All of us want our baby ultrasonic hearing back

 

Well in regards to that, we might as well shut this thread down until frequency posts another news bulletin or they wrap up this phase of their trial and report their findings. I also wouldnt call us communicating ideas while we seek answers "pollution".

well, phase 2 is happening now and scheduled to last 3 - 4 months, so you're wrong.

 

https://www.clinicaltrials.gov/ct2/...equency+Therapeutics&cond=Hearing+Loss&rank=1
Here is information about a single-phase study of FX-322.

As a criteria for inclusion in the test, noise-induced hearing loss or sudden hearing loss is indicated. About ototoxicity nothing is said, I do not know if it is included in the concept of "sudden hearing loss".

Spoiler: Criteria for inclusion in the test

Inclusion Criteria:

1. Adult aged 18-65 years.
2. Established diagnosis of stable sensorineural hearing loss (no changes of 10 dB or more at any frequency) by standard audiometric measures for >6 months.
3. Documented medical history consistent with hearing loss being caused by noise exposure or sudden sensorineural hearing loss (documented audiogram at least 6 months prior to screening required).
4. Female subjects must be of non-childbearing potential or will need to utilize two methods of highly effective contraception during the study participation (e.g. hormonal contraception or an intrauterine device and condoms) or remain abstinent. Male subjects should use condoms with spermicide during the course of the study or remain abstinent. Subjects should not donate sperm or ova during the study period.

Exclusion Criteria:

1. Perforation of tympanic membrane or other tympanic membrane disorders that would interfere with the delivery and safety assessment of an intratympanic medication or reasonably be suspected to affect tympanic membrane healing after injection in either ear. This includes a current tympanostomy tubes.
2. Any conductive hearing loss of 10 dB or more at two or more frequencies in either ear.
3. A pure tone average of 70 dB or greater at 500Hz, 1000Hz, 2000Hz, and 4000Hz in the ear to be injected.
4. Active chronic middle ear disease or a history of major middle ear surgery, as an adult, in the ear to be injected.
5. Subject has had an intratympanic injection in either ear within 6 months of the screening visit.
6. History of clinically significant vestibular symptoms at the discretion of the investigator.
7. History of clinically significant systemic autoimmune disease (e.g. rheumatoid arthritis, Sjogren's syndrome, multiple sclerosis, psoriasis).
8. History of head or neck radiation treatment or exposure.
9. History of substance abuse within 2 years of the Screening Visit.
10. Positive urine pregnancy test or breast-feeding.
11. Any known factor, condition or disease that, in the view of the investigator, might interfere with treatment compliance, study conduct or interpretation of the results such as psychiatric disease or suicidal tendencies.

Contacts and Locations

 

I wonder if there are any members involved in the FX-322 trail. And if so will they be able to discuss it with us?

 

i could never get in because the satanic pure tonal audiogram says I have perfect hearing.

 

reading about the company's first trial, which was in australia...were any results ever released regarding success of the treatment? i know it was a safety trial and not supposed to be testing the effectiveness, but i'm still curious and can't find much online.
also, i'm ignorant so maybe this was a fear for no reason but...so the dormant cells stick around for a while in our bodies? ears, specifically? as i understand it, the gel which gets injected will wake up dormant inner ear hair cells. my concern being, if i've had ear issues for a long time, are my cells still viable? i will assume the answer is yes because it looks like the recent study makes no mention of a time window (such as only people that have been having issues for less than three years).

 

Yes, that it was tolerated.

There is nothing online that says anything about its effectiveness. We can only make inferences.

The patent information explains how they use the dormant cells to make new hair cells and also make more progenitor (dormant) cells.

The dormant cells aren't floating around your body, they line the base of the cochlea.

Are your cells still viable? Are mine? We don't know yet.

Go to MPP page 132 and start reading my posts even up through today. I've basically posted everything from medical papers that can possibly be known by us about this technology. Please ignore the bad memes and silly stuff.
https://www.tinnitustalk.com/threads/my-posting-place.23694/page-132

 

Frequency updated their website with this video:

Langer Karp Breakthrough Hearing

And this article:
http://www.frequencytx.com/our-approach/hearing-and-beyond.php

 

"Frequency’s initial focus is on chronic noise induced hearing loss."

To me, that is saying, we want to cure tinnitus!

But they are not saying that!

 

Can someone explain "We are focusing on noise induced hearing loss"?

If they are just regenerating hair cells, why does it matter whether it is noise induced, or from another cause, like ear infections, antibiotics, natural decay, ect.?

 

probably not, most people on this forum are discouraged from taking aggressive actions.

this isn't new we posted this months ago

 

I'm not sure but think it's due to the emergency response of the limbic system being involved. Loud noise, damaged hardware, brain compensates, limbic system regulates the compensation. By isolating 'noise induced tinnitus' the results of the study address this specific model. Which seems to be the majority of the 10 million sufferers of severe tinnitus.

 

In some other press releases such as the requirements for the phase 1/2 trial they also mention that SSHL and other causes can be eligible for inclusion in the trial.

 

Sent my hearing test to them yesterday. First one was 30db loss at 4K 2nd was 35. My loss drops to 40db at 6k. I think I’ll get in because I’m very healthy otherwise and fairly young compared to most people with hearing loss.

 

Don't say that tinnitus is your primary complaint otherwise they pry wont let you in.

 

@Deathtotinni if you don't mind me asking do you know how you got your HL? Was it from skull fracture (displayed as your cause of T)?

 

is this possible? isn't the trial underway already?

 

On second thought, Frequency Therapeutics is probably heavily funded by military/government due to war veterans/IED's.

This may explain why "We are focusing on noise induced hearing loss".

 

funded, not heavily.

https://www.businesswire.com/news/h...-Department-Defense-Awards-2M-Grant-Frequency

the real government funding is reserved for the hard science:

https://www.washingtonpost.com/news...study-lesbian-obesity/?utm_term=.1af144544a8b

 

that is great news
if the phase 2 tests are good we can have the drug synthetized and try the injection on ourselves well before it will be released
phase 3 and approval may take 5 year or more

 

I want a DAM cure please this is no way for a person to live its nothing but pure suffering a suffering that only a person with it knows I sent my hearing tests to these guys months ago they where rude and did not care what I was going through my loss starts at 6000 going down to 40db at 8000 its 45db my brain sounds like a lazer cutting glass it started when I was a strong 40year old that was four years ago now I look like a dying 80year old man im so done with it all there is nothing they can do there is not even a little hope of nothing its all about how they can get money im so tired of this noise sorry for venting just a bad day wishing these Dr.s carried but they DONT NONE OF THEM DO

 

this is old news

 

This is our tax are dollar hard at work, y'all.

If they can spend money on bridges to nowhere they should be able to spend more on hearing loss for vets (with us benefitting of course).

 

Cant wait for this to come out.

 

]Frequency updated their website with this video:
And this article:
http://www.frequencytx.com/our-approach/hearing-and-beyond.php

So Then, this Article been updated by them about 2 weeks after of the anouncement in the same Fx website of the beginning of trial 1/2. Coould it have a positive meaning? I mean, could it be possible that they already have any “eficacy data”?