Inner Ear Hair Cell Regeneration — Maybe We Can Know More

[attheedgeofscience]

Thanks for the details.

I am still here in China for another four days, my final IV injection is in three days. I hope to see an improvement in my hearing in the next few months. I have luckily habituated to my tinnitus some time ago.

For some reason I cant open a private conversation with you, I would highly appreciate if I were able to ask you 2-3 questions in private. Just 2-3 questions and no more. If you have an email I can send to?

Also, how long did it take you to get that 25db back. If I recall it was 3 and a half months?

All the best.

It's because I have amended my settings so as to not receive incoming messages via private mail. I will open up a conversation with you; feel free to ask anything you want. I generally prefer to keep my conversations "open" - as I have no hidden agenda on this board - but I have no problems with a private dialogue or two, when needed...

The 25db improvement I got at 8 kHz from LLLT was over a two month period of consistent LLLT.

 

[attheedgeofscience]

Thanks for the details.

I am still here in China for another four days, my final IV injection is in three days. I hope to see an improvement in my hearing in the next few months. I have luckily habituated to my tinnitus some time ago.

For some reason I cant open a private conversation with you, I would highly appreciate if I were able to ask you 2-3 questions in private. Just 2-3 questions and no more. If you have an email I can send to?

Also, how long did it take you to get that 25db back. If I recall it was 3 and a half months? It was Sensorineural hearing loss you had wasn't it?

The colour of these Umbilical chord stem cells, was it yellow-ish?

All the best.

The stem cells I got were delivered in a bottle which looked like this:



They were definitely not yellow-ish in colour (and neither were the stem cells I received in Bangkok).

 

[attheedgeofscience]

Some people have been asking about the effects of stem cells on eczema/psoriasis and other auto-immune disoders. In the summer of 2011, I began to apparently develop an auto-immune disorder (see picture below). I would get seriously irritated eyes within the timespan of 45 minutes. This would occur once every 2 months or so (for no apparent reason - and also off-season in terms of allergies). I had been seeing an eye doctor each time, but by the 3rd occurence, I decided to go back to my GP (in order to identify the underlying reason; this was also the recommendation of the eye specialist who saw me each time and treated me with local eye steriods). However, my GP recommended seeing an ENT or a dermatologist for the usual allergy test evaluation. Obviously, I declined her suggestion as any fool can see that the symptoms are not allergy related. I therefore decided to do my own research, and refer myself to a specialist "later on". Fast forward a couple of years, and after my first stem cell treatment - and especially after my second - I have had no further "eye-attacks" and my eczema is 100% gone. My eye floaters - as consequence of the "eye attacks" - are also improving somewhat. Stem cells are excellent at regulating the immune system and actually curing auto-immune disorders and repairing the damage they caused...

 

[tomytl]

MENIERE STUDY lead by Otonomy
http://menieresdiseasestudy.com/

 

[tomytl]

Interesting reading about the Novartis Atoh1 trial. According to this read, Novartis invested 500 000 000$ in Aoth1 developement....
http://journals.lww.com/thehearingj...ser_to_a_Gene_Therapy_for_Hearing_Loss.6.aspx

It's retweeted from the hhf.org, so it's maybe really relevant.
I'm still surprised that a human trial for regrow inner ear cells has such a few apperance in
the media. They mostly write "cure for hearingloss" as headline if there is a test in the lab, but
when they apply it to human it's not so hype... hmmmm
http://journals.lww.com/thehearingj...ser_to_a_Gene_Therapy_for_Hearing_Loss.6.aspx

 

[JohnDoe]

Interesting article from 2012 about the restoration of hearing loss:

"New strategies for the restoration of hearing
loss: challenges and opportunities by Dr. Marcelo Rivolta"

 

[tomytl]

Interesting article from 2012 about the restoration of hearing loss:

"New strategies for the restoration of hearing
loss: challenges and opportunities by Dr. Marcelo Rivolta"

interesting article even I think use of stem cells is far from clinical use because of some reasons
discussed in this article from 2014.
https://hearinglosscure.stanford.ed...l-like-cells-from-human-embryonic-stem-cells/

But it's all exciting progress an Dr. Marcelo Rivolta will host the annual inner ear biology workshop
http://www.ieb2014.group.shef.ac.uk/

 

[FERNANDO GIL]

Very interesting article from Oxford University.
http://bmb.oxfordjournals.org/content/63/1/25.full

 

[tomytl]

Very interesting article from Oxford University.
http://bmb.oxfordjournals.org/content/63/1/25.full

This is interesting read but from 2002. Yehoash Raphael was one of the researchers who
made the first hair cell regeneration lab trial in 2003. This technology has been licensed
by Genvec/Novartis and is now in human trial in Kansas.

 

[FERNANDO GIL]

Finaly manage to make my high frequemy audiograme.
Here it is.

 

[attheedgeofscience]

Finaly manage to make my high frequemy audiograme.
Here it is.

Your audiograms a reminder to the medical community why very high frequency audiograms are necessary for a proper evaluation (excellent that you got them done). Your hearing is normal or "okay" for 0-8 kHz, but then drops drastically in your right ear (red line). You have significant hearing loss in that ear - and something must have happened in the past(?). All of this would have gone unnoticed during a standard screening used by most audiologists (0-8 kHz).

Your hearing loss is not bilaterally symmetrical. There is no bone conduction test for > 8 kHz, but it looks as if there was a bone conduction test done for 0 - 8 kHz(?). Very high frequency hearing tests should be doubled checked with a pulsed frequency to eliminate the influence of tinnitus in the background; the brain is not "used to" hearing high frequencies - and these can be difficult to hear as we are not used to these tonal sounds above 8 kHz. Your tinnitus is almost certainly caused by damage to the cochlear (= hearing loss). The 0.125 kHz frequency was left out; the 3 and 10 kHz frequencies were included (which is slightly unusual). There is no test for 6 kHz - which should have been done (both 4 and 6 kHz are indicators for noise induced hearing loss).

Your vocal audiogram is slightly worse than normal. But only slightly.

That is what I see. Which is probably also what you see.

If you have any questions, let me know.

 

[FERNANDO GIL]

My Tinnitus started after an ear infection last December, and almost for sure to the use of some bad ear drops to aliviate.
It eaxactly 2 days after.

Now the point for the future, the way I see it. Is if with LLLT and maybe in the future with Steam cell injection.The cells can REGENERATE, at least some. I think I saw a post from you and I think you had same problem with ear drops as well.

Next monday I will meet Dr Wilden and start from there. And go same way you did. Around Septenber /October i will go for the stean cell injections. Fot now is all I can do to keep the hope.

Thanks for the input.

 

[tomytl]

My Tinnitus started after an ear infection last December, and almost for sure to the use of some bad ear drops to aliviate.
It eaxactly 2 days after.

Now the point for the future, the way I see it. Is if with LLLT and maybe in the future with Steam cell injection.The cells can REGENERATE, at least some. I think I saw a post from you and I think you had same problem with ear drops as well.

Next monday I will meet Dr Wilden and start from there. And go same way you did. Around Septenber /October i will go for the stean cell injections. Fot now is all I can do to keep the hope.

Thanks for the input.

Are you going to Ibiza for LLLT?
Do you know why he changed he's location from Regensburg to Ibiza?
Webpage still doesn't show new location.

 

[FERNANDO GIL]

Are you going to Ibiza for LLLT?
Do you know why he changed he's location from Regensburg to Ibiza?
Webpage still doesn't show new location.

-Yes, I will try 5 seesion, and possible buy a LLLT.
- For what I read, last year was big floods in Southern Germany is was flooded and he decide to move to Ibiza, is soon i think have a clinic in Germany
- If you interested call him. He always answer the phone, (at least until now) the phone is on the website. Spanish phone ( 00 34) 605215906

Anything you know?

 

[attheedgeofscience]

-Yes, I will try 5 seesion, and possible buy a LLLT.
- For what I read, last year was big floods in Southern Germany is was flooded and he decide to move to Ibiza, is soon i think have a clinic in Germany
- If you interested call him. He always answer the phone, (at least until now) the phone is on the website. Spanish phone ( 00 34) 605215906

Anything you know?

Nice cover story...! Indeed, there was serious flooding in Bavaria last year right around this time (my first appointment with him in Regensburg was delayed because of the flooding, in fact). But no, it is not because of the flooding that he has decided to move, but I will not disclose the exact circumstances in a public forum. He can indeed be contacted via phone (as always). He is based in Ibiza now.

I wish you every success on your journey. And don't forget earplugs: nightlife on Ibiza can be - shall we say - a little loud (as I am sure you know!!!). Perfect place for a tinnitus clinic, in fact...

 

[attheedgeofscience]

My Tinnitus started after an ear infection last December, and almost for sure to the use of some bad ear drops to aliviate.
It eaxactly 2 days after.

Now the point for the future, the way I see it. Is if with LLLT and maybe in the future with Steam cell injection.The cells can REGENERATE, at least some. I think I saw a post from you and I think you had same problem with ear drops as well.

Next monday I will meet Dr Wilden and start from there. And go same way you did. Around Septenber /October i will go for the stean cell injections. Fot now is all I can do to keep the hope.

Thanks for the input.

If your tinnitus started exactly two days after using ear drops, then I honestly don't think the ear drops caused the hearing damage. A responsible ENT would look at the eardrum to see if it is punctured before prescribing meds. If not, then ear drops should be relatively safe for a short course. Ototoxicity takes more than two days to develop. Probably the damage was done by the infection. My opinion.

See how you get on in Ibiza, but...

If you are interested in improving your hearing, then LLLT + stem cells is worthwhile looking into, however...

If you are interested in improving your tinnitus, then a focused therapy such as HIFU or clinical trials are the better option, I think...

Take care.

 

[FERNANDO GIL]

Hi Ateos
I was in Indonesia whem I myself decide to take the ear drops, exactly due a big ear infection.
Clinical trials out of Portugal is almost impossible to have. But I´m more willing to go for the HIFU therapy before going to make the steam cells, I will go to see Dr Wilden any way.
Any way you can help on trying the HIFU therapy?

Many thanks once again.

 

[tomytl]

Hi Ateos
I was in Indonesia whem I myself decide to take the ear drops, exactly due a big ear infection.
Clinical trials out of Portugal is almost impossible to have. But I´m more willing to go for the HIFU therapy before going to make the steam cells, I will go to see Dr Wilden any way.
Any way you can help on trying the HIFU therapy?

Many thanks once again.

Keep us informed about the LLLT therapy in Ibiza. I'm still using some home lasers,
unfortunately without any noticable change on T/HL/Pressure in the ears.

 

[FERNANDO GIL]

Yes i read that.....

 

[FERNANDO GIL]

If your tinnitus started exactly two days after using ear drops, then I honestly don't think the ear drops caused the hearing damage. A responsible ENT would look at the eardrum to see if it is punctured before prescribing meds. If not, then ear drops should be relatively safe for a short course. Ototoxicity takes more than two days to develop. Probably the damage was done by the infection. My opinion.

See how you get on in Ibiza, but...

If you are interested in improving your hearing, then LLLT + stem cells is worthwhile looking into, however...

If you are interested in improving your tinnitus, then a focused therapy such as HIFU or clinical trials are the better option, I think...

Take care.

I got it, is in Swiss. But not available for the moment i think?

 

[tomytl]

Interesting read about hair cell regeneration from University Barcelona Spain:
http://www.upf.edu/cexs/actualitat/audition.html#.U54tubFCma8

 

[tomytl]

One more company with a hair cell regeneration project in their pipeline:
http://www.acousia.com/

Interesting: One of the member, Prof. Dr. Hubert Löwenheim founded already in 1998
Otogene in Tuebingen Germany based on a first finding of cell cylcle regulatory called
p27kip1. Otogene inc. has been ceased and new founded Sound Pharmaceuticals has been
added p27kip1 to it's pipeline. (even there hasn't been any updates on this regenerative approach for years)

on their page they write:
Since there is no causal medical treatment for hearing loss today, the goal of ACOUSIA is to establish drug development of small molecule compounds that trigger regeneration of sensory hair cells and allow for causal treatment of sensorineural hearing loss in patients who already lost their hair cells years ago.

Let's hope that acousia can restart and bring some new drugs on the market

 

[FERNANDO GIL]

Hello
Two days in Ibiza, just felling better, maybe placebo.
But did happen exactly what Dr Wildeb said. A loud tinnitus on the first day, and the calm down.
But was a long time ago i did not wake up so calm and the tinnitus so low.
Let´s hope for the best, is only the beginning. I always manage my life, that you don´t know till you try. So here i´m doing exactly that.

 

[tomytl]

Hello
Two days in Ibiza, just felling better, maybe placebo.
But did happen exactly what Dr Wildeb said. A loud tinnitus on the first day, and the calm down.
But was a long time ago i did not wake up so calm and the tinnitus so low.
Let´s hope for the best, is only the beginning. I always manage my life, that you don´t know till you try. So here i´m doing exactly that.

Hi Fernando,
this is great if you have success!! What about hearing? Is there also an enhancement?
How is the new clinic?

All the best
Tom

 

[Champ]

Interesting read about hair cell regeneration from University Barcelona Spain:
http://www.upf.edu/cexs/actualitat/audition.html#.U54tubFCma8

I honestly think this has insanely legitimate potential. If you believe in evolution, you should realize it's possible for the "first" mammals to have been generated and mutated without the ability to inhibit Notch, unlike animals such as birds (supposedly evolved from dinosaurs) and reptiles. We do have very similar hearing systems - theirs just doesn't block the ability to regrow hair cells, and they naturally regenerate them just like we'd regenerate if we hurt our hands or broke our bones. I suspect it'll be a either a drug to block Notch, gene therapy, or a clever combination of both. Given the number of people researching the solutions, and the number of companies getting involved, it's a matter of how fast the research can progress. We should be seeing results in legitimate scenario 5-10 years, if you were to ask me. It may take longer to really get it to the masses, but given the incidences of hearing loss and tinnitus nowadays, there is a lot of pressure to push forward and produce workable solutions.

 

[tomytl]

I honestly think this has insanely legitimate potential. If you believe in evolution, you should realize it's possible for the "first" mammals to have been generated and mutated without the ability to inhibit Notch, unlike animals such as birds (supposedly evolved from dinosaurs) and reptiles. We do have very similar hearing systems - theirs just doesn't block the ability to regrow hair cells, and they naturally regenerate them just like we'd regenerate if we hurt our hands or broke our bones. I suspect it'll be a either a drug to block Notch, gene therapy, or a clever combination of both. Given the number of people researching the solutions, and the number of companies getting involved, it's a matter of how fast the research can progress. We should be seeing results in legitimate scenario 5-10 years, if you were to ask me. It may take longer to really get it to the masses, but given the incidences of hearing loss and tinnitus nowadays, there is a lot of pressure to push forward and produce workable solutions.

I think hair cell regeneration comes along with applications for the eye. There have been made some significant advances and some of novel therapies are at Phase III.
And first proof of concept trial is going on for hair cell regeneration, which is very exciting and hopefully
successful.
I'm also very excited about the next event at Stanford
https://hearinglosscure.stanford.ed...g-exploring-the-challenges-and-possibilities/

They will provide a video shortly after the event.

 

[FERNANDO GIL]

I think hair cell regeneration comes along with applications for the eye. There have been made some significant advances and some of novel therapies are at Phase III.
And first proof of concept trial is going on for hair cell regeneration, which is very exciting and hopefully
successful.
I'm also very excited about the next event at Stanford
https://hearinglosscure.stanford.ed...g-exploring-the-challenges-and-possibilities/

They will provide a video shortly after the event.

The interesting thing, is that for many years hair cell regeneration was impossible, and now we see a lot companies trying to regenerate ear cells. Even big universities. So maybe Dr Wilden is correct. I hope so.

 

[tomytl]

The interesting thing, is that for many years hair cell regeneration was impossible, and now we see a lot companies trying to regenerate ear cells. Even big universities. So maybe Dr Wilden is correct. I hope so.

Does Dr. Wilden support the idea of hair cell regeneration using Gene Therapy or Stem Cells?

 

[FERNANDO GIL]

Don´t think so. He just says that they can regenerate. Of corse he tries to sell is theory. And note that are
Generation of hair cells and Regeneration of hair cells.

 

[attheedgeofscience]

I got it, is in Swiss. But not available for the moment i think?

You need to give Professor Jeanmonod a call. If you are serious about the treatment, I suggest you send your audiograms in advance of making the phone call. Based on my understanding of the treatment, your audiograms would indicate enough "loss of auditory input" to justify a clinical evaluation using EEG. He speaks French, German, and English; you would need to be comfortable in either of those languages. There is a waiting list.

It is unclear exactly when he will perform the first surgeries specifically for tinnitus. Again have the conversation with him first and ask whatever you would like. My own conversation with him lasted about 20 minutes. It is a pleasure to speak with him.

I am glad you are seeing results from your treatment with Dr. Wilden - even if they are only transient (to begin with). I have only the greatest respect for people who choose action over inaction.