Inner Ear Hair Cell Regeneration — Maybe We Can Know More

http://www.cell.com/cell-reports/fulltext/S2211-1247(17)30390-X
This one that you referenced is about hair cells. I never looked at the other one

 

Who would be next "most" advanced in the neuronal stem cell research field?

 

Ha, I couldn't answer that question. But I would take opinions from the Japanese labs and R0bert Jackler's colleagues over at St@nf0rd as a good guide. Although I am sure there are those working on the eye and spinal cord that have a much more comprehensive understanding of neurogenesis and stem cells than what is seen in otology.

 

Thanks for sharing this, I found it on a google search. I do like to see what others are reading.
goo.gl/4Ab7Pg

 

Robert Jackler and colleagues from Stanford University.

 

Ricci, Jackler, Heller and Grillet.

 

News from another lab:

https://www.sciencedaily.com/releases/2017/04/170411151001.htm

 

the last paragraph you respond to about it not working in humans, what is that paper/where did you source it from? cheers!

 

Agree.
Also
"The synaptic recovery was limited to the regions of the cochlea that respond to high-frequency sounds,"
We don't know if that is because the NTF-3 did not reach further in the cochlea.

"and the approach taken in this study probably will not restore hearing function in persons in whom the sensory hair cells have died."
That to me is so obvious. How can you restore synapses on non existing hair cells?
This research is already more than 2 years old.

 

Yamanaka, imagine we had him in otology.

 

@Samir This is great news. Are these supporting cells listed this NEJM article the same ones that Frequency induces? Does Frequency's newly created hair cell also have supporting cells they are contain within? How many synaptic connections would a newly create Frequency hair cell make?

Does the supporting cells with this growth factor create synaptic connections to dead hair cells or does the body know when a hair cells is dead and not use up synaptic connections to it. I hope the latter but has this been proven? Would tinnitus exist if synapses were connected but connected up to non-function or semi functional hair cells? Do dead hair cells remain and if they get absorbed how long after death does this process take? Can semi-functional hair cells exist or is completely effective or dead the only options for hair cells? Can we get a non-invasive uOCT probe today so researcher, this forum, and I are inferring the based on cloudy data?

"The authors generated conditional mouse models in which Ntf3 expression was increased specifically in cochlear supporting cells."
How was Wan able to do this? If viral vector then can some lab test out on a primate NT-3 induction of the supporting cells via one of these viral vectors (ANC80 whatever etc). Please!!! If a test showed synaptic connections in primates would be game over for tinnitus/hearing loss via noise damage.

I still think the combination of gene therapy inducing production of NT-3 and BNDF in the supporting cells weeks before and shortly after a Frequency dosage is the clear best answer to hearing restoration with the current technology. I been thing over the past weeks that cooperation and coordination between Decibel and Frequency would enhance both of their treatments. Do companies like these coordinates without a merger? Maybe one can buy out the other or vice versa. Regardless with the big if that both companies have viable treatments in 1.5 years I would recommend people with noise induced hearing loss start a Decibel treatment before a Frequency treatment.

 

Does anybody here actually read papers? The NEJM paper is just a commentary/explanation of a paper published in 2014. There is NO research in the NEJM paper. I have no idea why people are focused on a discussion of a 3 year old paper.

 

If a treatment to cochlear neuropathy develops and Frequency is successful I would expect a noble for Liberman, Karp, Langer, and maybe others will receive a noble along with a lot more research money. So not just from TT but they will get worldwide accolades.

 

They give out prizes to at the B@rany and the Pr0sper Meniere's society, a prize for this and a prize for that. So while they are busy feeding their narcissism with shiny medals patients are out there suffering, some committing suicide. Forget the prizes, how about we shut the funding off for the labs that don't produce. The current holder of the prosper meniere's s0ciety gold medal is in love with his own work so much, that he plasters his own references across all his publications, lots of papers, lots of ear theory and not one single treatment for anything, yet he gets funding for publishing frequently while younger more ambitious scientists get nothing. I still believe the patient body needs to make its presence felt in a powerful manner to deal with those who seem to be lost at sea. The funding is the weak spot of the research arm that can be exploited to control its direction.

 

Wtf is wrong with this jeff w dude?? Why does he mask the names????

Barany and the Prosper Meniere's Society Gold Medal

 

I don't know what is and what is not indexed on google searches so I just don't want to attract unwanted attention to this site, that's all.

I have no problem with G0ebel. It is the older members that are hanging around well past their usefulness. We must have a constant stream of youth arriving at these labs. I will soon be posting a speech from a patient who has tried to outline the sort of problems I refer, his story is remarkable.

 

Regards

The great and masterful

Jeff W
Jeff W
Jeff W
Jeff W
Jeff W
Jeff W
Jeff W
Jeff W
Jeff W
Jeff W
Jeff W
Jeff W
Jeff W
Jeff W
Jeff W
Jeff W
Jeff W
Jeff W
Jeff W
Jeff W
Jeff W
Jeff W
Jeff W
Jeff W
Jeff W
Jeff W
Jeff W
Jeff W
Jeff W
Jeff W
Jeff W
Jeff W
Jeff W
Jeff W

 

I missed this from the New Yorker Article. It seem Liberman is very optimistic and confident about future neuronal re-connections. When he is talking about local delivery does that mean growth factors or some other substance that hasn't been disclosed(maybe by Decibel )?

http://www.newyorker.com/magazine/2017/04/03/high-tech-hope-for-the-hard-of-hearing

"Nonetheless, among researchers, the discovery has been a cause for optimism, because reconnecting nerve synapses is almost certain to be easier than regenerating functioning hair cells inside human ears. “This is the simplest sensory circuit that you could possibly have,” Liberman said. “It’s one sensory cell type and one neuronal cell type, and it’s possible to do local delivery through the eardrum.” He and others have successfully restored some damaged connections in lab animals, and he believes that far greater advances are to come. “In the past five years, there’s been an explosion of biotech companies getting serious about the inner ear for the first time,” he continued. “I think most people in the field would say it’s no longer a question of if we will be able to unlock enough of the secrets but merely a question of when.”"