Inner Ear Hair Cell Regeneration — Maybe We Can Know More

Discussion in 'Research News' started by Hopeful, Sep 6, 2013.

    1. DoNotGoGentle

      DoNotGoGentle Member Benefactor

      Tinnitus Since:
      10/15 got worse 11/16
      Cause of Tinnitus:
      Earbuds, inner ear infection NHL and high frequency loss
      Yeah it is amazing went to tinnitus clinic told them about hearing restore they said only in mice don't hold your breath. Talked to an audiologist they had no idea about these companies. They work for hearing aid companies. As long as we have breath we have a chance everyday is a battle!
       
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    2. NatureHiker
      Angelic

      NatureHiker Member

      Turning down the CNS gain mechanism would be a starting point beyond the fixing hearing (conductive, sensorineural, etc)
       
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    3. NatureHiker
      Angelic

      NatureHiker Member

      Exactly. I've learned that this is an extremely niche topic. You wouldn't know much about this unless you actively kept up with research in the field. Which most ENTs, Audiologists, and doctors in general do not.

      I was flabbergasted that the many inner ear biology PhD candidates i talked to had not even heard of this research.

      All I'm saying is our naysayers don't have much credence unless their name is Dr. Salvi, Dr. Liberman, Dr. Tzounpolis, etc.
       
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    4. Reinier
      Not amused

      Reinier Member Podcast Patron Benefactor

      Location:
      Netherlands
      Tinnitus Since:
      06/2015
      Cause of Tinnitus:
      Explosion starting engine
      I only had the opportunity to talk briefly with audiologists, and ENTs during consultancy visits.
      I will never forget this one ENT that told me it could be within my lifetime NIHL is curable. So he heard ,read or even participated in research. I was to flabbergasted to ask him more about this at the time. Also unfortunately a visit to an ENT is very limited time-wise.
      Al other health professionals I talked to about this did not know about research or indicated it would not happen within decades, if ever. The fact some of them did not know, I still can not understand.

      Is this scepticism or realism? There must be so much research that has been going on for decades and still does not get any application for patients.

      Can the lay person comprehend the complexity of this regeneration process?
      Even after reading many documents like some of us do?
       
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    5. Foncky
      Tired

      Foncky Member Benefactor

      Location:
      Europe
      Tinnitus Since:
      March 2004
      Cause of Tinnitus:
      Music. Balloon. Genes.
      That's basically what Frequency has started to do. They tried their treatment on the human inner ear (from a dead body) already.
       
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    6. Fabrikat

      Fabrikat Member

      Tinnitus Since:
      1973
      Cause of Tinnitus:
      Otosclerosis then volume then viral infection
      As for hearing aid companies, there's not a lot of sounds of concern coming from these firms as far as I can tell. You would think they'd be starting to squawk about their rivers of gold potentially drying up. My audiologist knows nothing about hearing regeneration trials either.

      Which makes me think that perhaps no one is really taking any of this stuff seriously. If these trials show any kind of efficacy, these industries are in line for some serious disruption.
       
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    7. RonnieCarzatto
      Cynical

      RonnieCarzatto Member

      Location:
      Canada
      Tinnitus Since:
      Feb 01 2017
      Cause of Tinnitus:
      Mild head injury maybe... but who knows...
      @Fabrikat Well most audiologists still consider the 8khz hearing test as sacrosanct... despite it being out of date and only being useful to sell hearing aids :p How can those audiologists and hearing aid salespeople still be taken seriously...
       
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    8. walkthroughwalls

      walkthroughwalls Member

      Tinnitus Since:
      10/2014
      Cause of Tinnitus:
      Unknown
      It'll be like a new technology taking over. If you're in the horse-and-buggy business, there's just not much you can do even if you can predict the rise of the car. Another example is film photography and digital photography. The research and engineering are coming from an entirely different place, so getting involved with the new technology would essentially mean rebuilding the old company from the ground up.
      It could be done, if a hearing aid company had realized that they're in the business of making people hear better and used their profits to get a foot in the curing hearing loss business. But that's a pretty rare move for any established company.

      Once a cure for hearing loss arrives, the hearing aid companies probably aren't that cynical that they'll start complaining about their profits. They'll quietly fade away. Like our tinnitus.
       
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    9. Flamingo1

      Flamingo1 Member Benefactor

      Location:
      Orlando, FL
      Tinnitus Since:
      4-15-2017
      Cause of Tinnitus:
      Acoustic trauma
      The breakthroughs are relatively recent so I do think the tide is turning and that help is on its way. As others have stated, a medical cure for hearing loss is against the best interests of audiologists who will face a shrinking market for their $3000 hearing aids. When I brought up the recent research to one audiologist, he tried to scare me by saying the treatment to regenerate hair cells would cost a patient $50,000 [sic]!! Yeah... right....
       
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    10. Reinier
      Not amused

      Reinier Member Podcast Patron Benefactor

      Location:
      Netherlands
      Tinnitus Since:
      06/2015
      Cause of Tinnitus:
      Explosion starting engine
      Where can I apply for treatment :D
      It is not that I am wealthy, but if there ever was a reason to get the money this is it.
      Work day and night and see what I can sell :).

      But I agree. Although there is not yet prove that hair cell regeneration can happen in humans and improves hearing, I am optimistic.
      How can you not be after all that is happening in 2017 alone.
       
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    11. Samir
      Obedient

      Samir Manager Staff Benefactor

      Location:
      Sweden
      Tinnitus Since:
      12/2016
      Cause of Tinnitus:
      Accoustic trauma
      God help us all! :D

      What's possible has already been done. It's the impossible that's interesting.

      Even before I got tinnitus I was interested in the seemingly impossible things. I used to read pop-sci magazines as well as sci-fi comics. The fine line between science fiction and science fact is ever so small. I say strive for the impossible! Don't let the naysayers have the last laugh. :)
       
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    12. Paulmanlike

      Paulmanlike Member Benefactor Hall of Fame

      Tinnitus Since:
      2008
      Cause of Tinnitus:
      Noise
      @Samir I will test my ears later to get back to you whether I can hear up to 16khz (t in left ear)
       
    13. Coleoptere
      Alone

      Coleoptere Member

      Location:
      The Hague
      Tinnitus Since:
      2002
      Cause of Tinnitus:
      Bell's Palsy, hearing loss
      They are aware of the developments. I read somewhere that they expect that the hearing aid market will disappear between 10-20 years. Hearing Health foundation - also doing hearing cure research - is sponsored by several hearing aid companies. Modern companies understand that the markets will change and might dry out one day sooner or later.
       
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    14. Paulmanlike

      Paulmanlike Member Benefactor Hall of Fame

      Tinnitus Since:
      2008
      Cause of Tinnitus:
      Noise
      From the journals I have read, inner hair cell regneration may only work on regeneration SOME hearing loss and only in the case of acute hearing loss??
       
    15. NatureHiker
      Angelic

      NatureHiker Member

      Hearing aids as an industry are going to drop drastically in value. There's a bill in Congress that both Democrats and Republicans support for making hearing aids OTC. Less market entry barriers = more competitors = cheaper hearing aids.

      I don't think there's an industry that can or would get in the way of a treatment that cures sensorineural hearing loss.
       
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    16. layzell

      layzell Member

      Tinnitus Since:
      09/2016
      Cause of Tinnitus:
      inner ear infection
      Is Coleoptere saying that causes of deafness such as hair follicle damage of the inner ear are the only cause of tinnitus?
       
    17. jeff W

      jeff W Member

      Location:
      nakatomi plaza
      Tinnitus Since:
      04/2012
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    18. Samir
      Obedient

      Samir Manager Staff Benefactor

      Location:
      Sweden
      Tinnitus Since:
      12/2016
      Cause of Tinnitus:
      Accoustic trauma
      The ringing! The ringing! :eek:

      Oh? So noise induced hearing loss is well defined? They still don't know all the details, like what part of the ear gets most damaged. For example, this new thing they call hidden hearing loss! The current studies seem to suggest that nerve synapses are even more prone to damage than the hair cells. The technical term for "hidden hearing loss" is cochlear synaptopathy or cochlear neuropathy. They intentionally picked this name because it offers them more slack, while they work out the kinks in the theory.

      I could say something like: "The TV is broken!" This is very different from saying: "The TV is broken, because the 4700 µF capacitor is borked on the daughter board." This is very descriptive and specific.

      Scientists never really have a definitive answer to a given question. It's all based on current understanding, on working knowledge. It's a constantly evolving body of knowledge.

      The thing about ears and hearing is that we have gained a lot of new insights in the past 20 to 30 years, and it's the ambition of a select few to try to translate these findings into practical applications. Ultimately, that's what science is for! It's meant to help us understand nature and improve our living condition. But scientists are never in a hurry to translate the findings into practical applications. That's not really their job either. That's where money and business comes in.
       
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    19. Paulmanlike

      Paulmanlike Member Benefactor Hall of Fame

      Tinnitus Since:
      2008
      Cause of Tinnitus:
      Noise
      @Samir plz answer my above question
       
    20. Samir
      Obedient

      Samir Manager Staff Benefactor

      Location:
      Sweden
      Tinnitus Since:
      12/2016
      Cause of Tinnitus:
      Accoustic trauma
      Med-El has made an investment in Audio Cure.
       
      • Informative Informative x 1
    21. Samir
      Obedient

      Samir Manager Staff Benefactor

      Location:
      Sweden
      Tinnitus Since:
      12/2016
      Cause of Tinnitus:
      Accoustic trauma
      As I said before, Med-El has made an investment in Audio Cure. Just as an example.

      Not necessarily modern, but smart companies do.
       
    22. Samir
      Obedient

      Samir Manager Staff Benefactor

      Location:
      Sweden
      Tinnitus Since:
      12/2016
      Cause of Tinnitus:
      Accoustic trauma
      Even something like that would mean a lot for a lot of people.

      This reminds me of "MD Hearing Aid".
      https://www.mdhearingaid.com/

      https://www.consumeraffairs.com/health/hearing/md-hearing-aid.html

      Cheap Hearing Aids & Devices: Helpful or Harmful?
      http://www.healthyhearing.com/report/47436-Cheap-hearing-aids

      I can't wait for these stories to become the thing of the past.
       
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    23. NatureHiker
      Angelic

      NatureHiker Member

      It seems the main opposition to OTC hearing aids are Audiologists and other hearing specialists. They say people don't have the ability to properly check their own ears for problems and to fit and utilize hearing aids.

      For people without hearing problems this seems reasonable, but to us who do we all know about the hearing aid racket and how useless Audiologists and ENTs are.

      But I wouldn't worry. Republicans and Democrats both support this bill. It'll pass. Then you can get hearing aids at best buy or Walmart.
       
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    24. Samir
      Obedient

      Samir Manager Staff Benefactor

      Location:
      Sweden
      Tinnitus Since:
      12/2016
      Cause of Tinnitus:
      Accoustic trauma
      Maybe it's just me, but I get the impression that they are not so eager to go out of their way to help people avoid hearing loss in the first place.

      Well here in Sweden you can get them for free basically if an audiologist has checked your hearing and he or she thinks you need hearing aids. We have public healthcare insurance that covers the cost, up to certain price point or you select from a catalog of models.

      We have audiologists working at public hospitals and commercial/private audiologist clinics. There was a big scandal here recently, where a certain multinational audiologist chain was found guilty of pushing their customers to buy other brands and more expensive models than the ones they otherwise would have gotten for free. They convinced them how those models were inferior. Plus, the audiologists selling the more expensive models were getting bonuses for doing so. It made it to national news. People who got their hearing checked at public hospitals instead didn't get this sales pitch.

      What's wrong with getting hearing aids for free? They can't be that bad? They are not these cheap "personal sound amplification" devices that are sold in the US. They are proper hearing aids. The only problem may be that they are worth $1500 instead of $3000 and that the poor audiologist is not getting the bonus.
       
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    25. Flamingo1

      Flamingo1 Member Benefactor

      Location:
      Orlando, FL
      Tinnitus Since:
      4-15-2017
      Cause of Tinnitus:
      Acoustic trauma
      There are at least two well-defined targets for reversing NIHL that can be studied, cilia and synapses. Repair those and observe the effect on hearing. What are the well defined targets for curing tinnitus? In other words, what is the etiology of T? If you can't locate the aberration, how do you fix it? With tinnitus, I think we're still in Phase 1, ie locating the problem.
       
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    26. Samir
      Obedient

      Samir Manager Staff Benefactor

      Location:
      Sweden
      Tinnitus Since:
      12/2016
      Cause of Tinnitus:
      Accoustic trauma
      They are one and the same? At least that's what the good old doctors will have us believe. That's why I can't wait to see this hypothesis either confirmed or busted once and for all.

      But yeah, I get it. Tinnitus is more elusive.

      Even if it doesn't do anything for tinnitus, restoring hearing by biological means is a big step forward.
       
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    27. Jim51042

      Jim51042 Member

      Tinnitus Since:
      3/28/16
      Cause of Tinnitus:
      Headphone use
      Lol. Well here in the states our Congress is trying to remove pregnancy as a mandatory benefit on insurance plans while giving tax cuts to the 1%.
       
    28. grate_biff
      In pain

      grate_biff Member Benefactor

      Location:
      Moss, Norway
      Tinnitus Since:
      09/2014
      Cause of Tinnitus:
      Acoustic trauma using headphones
      I just need to regenerate my cochlea HC and the GABA-receptors in my brain. Then I'll be happy!!
       
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    29. Samir
      Obedient

      Samir Manager Staff Benefactor

      Location:
      Sweden
      Tinnitus Since:
      12/2016
      Cause of Tinnitus:
      Accoustic trauma
      Thanks for posting! I just found this article today. I found this part very exciting:

      From the looks of it, Decibel is doing rudimentary research to get a better grip on the problem that they need to solve. I hope they have this registry by now and that it contains a significant amount of data already.

      They have now sided with Google to do the number crunching with. I am looking forward to hear more about Decibel and what they are up to.

      How to submit data to Decibel's database? I wish I knew. And those of you that visit an ENT clinic, please inform them about the Tinnitus Database. See the link below.

      https://www.tinnitus-database.de/
       
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    30. Samir
      Obedient

      Samir Manager Staff Benefactor

      Location:
      Sweden
      Tinnitus Since:
      12/2016
      Cause of Tinnitus:
      Accoustic trauma
      If we could only come up with a way to do it at home... :D
       
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