MemberI have read that this could become a serious problem because the structure of the cochlea will change. Supporting cells also physically support and make the organ of Corty. Trans differentiation of supporting cells is the way
Inner Ear Hair Cell Regeneration — Maybe We Can Know More
- Thread starter Hopeful
- Start date
bill 112
Member
I am so useless on computers with posting links so apologies for not being able to back up anything I say but believe me when I say what I say that's all I can ask but I read a research paper stating that they may have a way to produce more supporting cells after regeneration has occurred.It was something along the lines of gene manipulation but there is a way around it,possibly at least.I have read that this could become a serious problem because the structure of the cochlea will change. Supporting cells also physically support and make the organ of Corty. Trans differentiation of supporting cells is the way
As for your other comment about the gene discovery in H not being good it's anything but that,it's another huge leap into understanding the mechanisims involved and as nothing gets cured without knowing what's actually wrong it's a huge leap in the right direction in my opinion.As Nick as said numerous times now there's more and more evidence pointing at auditory nerve degeneration being the culprit.Any discovery is welcome if you ask me.
No, because when better treatments come, you're screwed.
You need your supporting cells.
I believe you. No reason not to. What would be ideal in my opinion is that the supporting cell adjacent to the damaged or dead haircell trans differentiates. We will have e new supporting cell at the same location with a functioning haircell next to it. That means nothing is changed from the original undamaged situation.
Absolutely. What I was "disappointed" about is there could be additional damage. Not only inner ear damage. The idea being, that if inner ear damage can be repaired, we are not there yet.
It actually made me wonder if people that experience tinnitus in the brain opposed to people that experience tinnitus in the ears could have different damage.
Every discovery can only be a positive contribution to the end-goal. A cure for hearing loss/issues. Also when it changes existing scientific paradigms.
That I think is an interesting notion.
I have been thinking about this too.
When we ever come to the situation where we can think about this, is an interesting time.
The first remark, I remember, was made just recently when someone from Audion, (if I remember correct), stated that their upcoming clinical trials would yield better results than the ones from GenVec at the moment.
Just form a mental image (-;
Having to decide means there is something available and future looks bright.
That I think is an interesting notion.
I have been thinking about this too.
When we ever come to the situation where we can think about this, is an interesting time.
The first remark, I remember, was made just recently when someone from Audion, (if I remember correct), stated that their upcoming clinical trials would yield better results than the ones from GenVec at the moment.
Just form a mental image (-;
Having to decide means there is something available and future looks bright.
I'm telling ya'll, these companies know more than they are leading on. The science is there and with what we'll learn from actual human trials will advance our knowledge 10 fold. If a company can regenerate even 10% or strengthen existing cells, they will be making billions. I'd be happy as a pig in sh*t if I could guarantee my hearing won't get any worse.
That I think is an interesting notion.
I have been thinking about this too.
When we ever come to the situation where we can think about this, is an interesting time.
The first remark, I remember, was made just recently when someone from Audion, (if I remember correct), stated that their upcoming clinical trials would yield better results than the ones from GenVec at the moment.
Just form a mental image (-;
Having to decide means there is something available and future looks bright.
The dutch will cure hearing loss (and hopefully Tinnitus with it) for everyone.
Let's make it a thing of the past. The collective suffering over these conditions took long enough now. I want to tell my grandchildren that people in the past could go (partially) deaf while still hearing all kinds of unwanted horrible sounds, but that none of that will be one of their worries. How beautiful that would be. I never liked the word "irreversible" anyway, especially when combined with "damage". It has so much negativity in it.
I'm already screwed. Screwed for sure now vs hypothetically screwed in the future, I prefer the latter. Not many people need their supporting cells today: we are a small minority here that could make use of them. There's a high probability I won't need them in the future, and I'm sure I need them now.
Also I'd rather be disabled when I have fewer years to live than now.
You may see the tradeoff differently, but that's how I see it.
The scientist that made this remark was not Dutch
.I still "put my money" on joint ventures like Hearing Health Foundation and Action On Hearing Loss Stanford initiative to cure hearing loss and some other universities in America.
The scientist that made this remark was not Dutch
I still "put my money" on joint ventures like Hearing Health Foundation and Action On Hearing Loss.
I was merely joking.
Of course the joint ventures will have a better chance of solving this complex issue (and probably faster). I'm glad for their existence and the fact that things are finally heading in a better direction for all of us with hearing issues.I'm excited to see where we stand in a few years time.
So was II was merely joking.
We could be pleasantly surprised if a breakthrough in regeneration comes from another field in medicine. (As an example) neuroscience.
Yes. Difficult to not get impatient.
It would be such an amazing accomplishment, regenerating parts of the inner ear.
And we could be there to experience it!
cornelius
Member
- Mar 18, 2016
- 72
- Tinnitus Since
- 2002
- Cause of Tinnitus
- several acoustic traumas, always physician denial
I want to be confident in regenerative medicine but I also fear because there are currently drugs on the market killing or disabling hundreds of thousand people every year (psych drugs, alzheimer drugs, statins, blood pressure drugs and many more) and however they are successful industries thanks to intense lobbying. Thus, how could we ensure that regenerative medicine won't be a part of the current iatrogenic genocide caused by pharmaceutical companies which deliberately conceals debilitating or deadly side effects ? (i.e sold as very good treatment but with more risks than benefits)
So was I
We could be pleasantly surprised if a breakthrough in regeneration comes from another field in medicine. (As an example) neuroscience.
Yes. Difficult to not get impatient.
It would be such an amazing accomplishment, regenerating parts of the inner ear.
And we could be there to experience it!
Since that day...
- This forum would be a place of rejoice and could be renamed into serenitytalk.com where we could just discuss the trivialities of life...
- Additionally, an annual ceremony will be held to honor all former tinnitus sufferers as veterans as we fought through this formerly horrible, intrusive, life-changing affliction...
- We will finally be recognized for the seriousness of our former condition...
- Our hearing losses will be reversed...
- GP's and ENT's from all over the world will line up for us with their apologies for treating us so harshly during our suffering...
- No one will have to go through all that again, ever!
What a beautiful day that would be...
Aw, shit! They even figured Tinnitus out already. What are we still doing here?
http://serenitytalk.com/listpost/home-remedy-for-tinnitus/
We cannot ensure that. However, what are the alternatives? We can continue living with an already debilitating condition or try this treatment. If the regeneration therapy proves to be useful in a majority of patients, which is needed for the product to reach it to market, then at least it offers you a significant chance things will get better.
Besides that, I believe the regeneration compounds are directly administered into the ear. It surely appears a lot better and more targeted than systemic drugs and their side effects, which might affect your whole body. That's like shooting a mosquito with a shotgun and has the potential to do more harm than good.
cornelius
Member
- Mar 18, 2016
- 72
- Tinnitus Since
- 2002
- Cause of Tinnitus
- several acoustic traumas, always physician denial
In this case I'll leave it to all the courageous who will be the first to dare using the cures if they exist one day. Their testimonies will be crucial, hopefully they won't be betrayed like all the elderly persons used as guinea pigs without full recovery purpose in the allopathic medicine.
Most important that next year in 2017
we get results from Novartis trial and see
Audion,Otologic,Sound Pharmaceuticals starting with their regeneration program.
Probably another company like Frenquency TX oder Decibel TX might also come along with something
Otonomy says also, that they aquired some stuff to fight age related hearing loss.
Also Roche has something under the hood with it's Inception 3 project, but there is not a lot of info.
The same for Affichem
in the Tinnitus field there are still AudioCure and Sensorion...
So many companies with the same goal finding a working inner ear therapy.
we get results from Novartis trial and see
Audion,Otologic,Sound Pharmaceuticals starting with their regeneration program.
Probably another company like Frenquency TX oder Decibel TX might also come along with something
Otonomy says also, that they aquired some stuff to fight age related hearing loss.
Also Roche has something under the hood with it's Inception 3 project, but there is not a lot of info.
The same for Affichem
in the Tinnitus field there are still AudioCure and Sensorion...
So many companies with the same goal finding a working inner ear therapy.
I did not realise Action On Hearing Loss is the biggest
Quote: "Action on Hearing Loss runs the world's largest donor-supported hearing research programme, dedicated to funding research into better treatments and cures for hearing loss and tinnitus."
http://www.medicalnewstoday.com/releases/312424.php
What exactly is "donor-supported"?
Does this mean not commercial, but people and businesses donate money?
Quote: "Action on Hearing Loss runs the world's largest donor-supported hearing research programme, dedicated to funding research into better treatments and cures for hearing loss and tinnitus."
http://www.medicalnewstoday.com/releases/312424.php
What exactly is "donor-supported"?
Does this mean not commercial, but people and businesses donate money?
So not two but more clinical trials will run/start in 2017?
More positive than I dared to hope.
2017 has been targeted by the 3 companies with start all the preparations. It will take some time until they will let people take their candidates.
The Soundpharma approach exists more than 15 years, so I guess it's a well tested treatment in the preclinics
Some for the Hough Ear/Otologic approach, I read about their first findings in 2005.
With Audion, I guess this approach started arround 2007 or so...
Genvec started in about 2005 and now it's in the trial, that's very exciting....
As long it always read like science fiction.
I hope one or at best all of them could tune the ears a little...
Quiet Exciting that some of them started to have their first findings 10 years ago.
and next years they would be able to test them,
i hope there is a positive outcome for everyone.
I did not realise Action On Hearing Loss is the biggest
Quote: "Action on Hearing Loss runs the world's largest donor-supported hearing research programme, dedicated to funding research into better treatments and cures for hearing loss and tinnitus."
http://www.medicalnewstoday.com/releases/312424.php
What exactly is "donor-supported"?
Does this mean not commercial, but people and businesses donate money?
I think it means that their funding comes with no strings attached: whoever gives the money doesn't receive anything back for it (no equity, no promises of returns, etc...) - i.e. it's not an investment.
I suspect it doesn't preclude the lab from making money from its research (patent licensing, etc).
This sumary sounds less optimistic:
http://www.dizziness-and-balance.com/disorders/bilat/regeneration.htm
http://www.dizziness-and-balance.com/disorders/bilat/regeneration.htm
I read it, i think its fine, well writen but to me its was more like "reasons why its difficult"
instead of "we have advance this far..." i think there might be interesting things on the way
in the upcoming months.
Let us just hope the GenVec trial started a snowball effect.
http://www.dizziness-and-balance.com/disorders/bilat/regeneration.htm
Quote: "this is not accompanied by functional improvements in hearing (Atkinson et al, 2014). The hair cells generated are not functional."
End quote.
I am confused now.
I distinctly remember different Pubmed summaries where hearing was improved after haircell regeneration in animals. Also I read that the new haircells connect. (They have to in order to improve hearing threshold).
Most of all: will GenVec/Novartis start clinical trials in humans when there was no improvement in hearing threshold in animals?
http://www.dizziness-and-balance.com/disorders/bilat/regeneration.htm
Quote: "this is not accompanied by functional improvements in hearing (Atkinson et al, 2014). The hair cells generated are not functional."
End quote.
I am confused now.
I distinctly remember different Pubmed summaries where hearing was improved after haircell regeneration in animals. Also I read that the new haircells connect. (They have to in order to improve hearing threshold).
Most of all: will GenVec/Novartis start clinical trials in humans when there was no improvement in hearing threshold in animals?
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