Knopp Biosciences

Discussion in 'Research News' started by attheedgeofscience, May 19, 2015.

    1. attheedgeofscience
      No Mood

      attheedgeofscience Member Benefactor Hall of Fame

      Tinnitus Since:
      Childhood
      Cause of Tinnitus:
      Head Injury
      As members of this forum may know we, @Team Trobalt, are tracking down information on pharmaceuticals involved in potassium channel modulator research. Knopp Biosciences is (probably) another pharmaceutical that most people are not aware of. However, tinnitus is actually mentioned (briefly) on their homepage:

      http://knoppbio.com/research/show.php?2

      Their product pipeline shows the following drug candidates...

      upload_2015-5-19_10-20-9.png

      ...and I have managed to track down that the "Kv7 platform" probably refers to the following compound(s):

      IMIDAZO(4,5-B) PYRIDIN-2-YL AMIDES (as KV7 CHANNEL ACTIVATORS)

      Knopp Biosciences has filed a patent application last year (see attachment) which, again, I believe is concerned with the drug candidate behind the mentioned "Kv7 platform" in the above overview. Interestingly, Trobalt/Retigabine is mentioned within the application.

      As with SciFluor, we will be attempting to contact a senior representative of the company to see if we can get a few more specifics.

      attheedgeofscience
      19/MAY/2015.
       

      Attached Files:

      • Informative Informative x 7
      • Like Like x 4
    2. Calories
      Surrender

      Calories Member

      Location:
      Bangalore, India
      Tinnitus Since:
      March 2015
      Cause of Tinnitus:
      B12 Difficiency, Possibly salycilic poising from fenugreek and ginger
      :thankyousign:

      They are yet to start animal model studies for tinnitus, So anything from them for tinnitus is at least 15 years away!:eek:
       
    3. Nucleo

      Nucleo Member Benefactor

      Tinnitus Since:
      02/2011
      Well to be fair, it's not like anyone else is significantly more advanced in the field of tinnitus.
       
    4. Nucleo

      Nucleo Member Benefactor

      Tinnitus Since:
      02/2011
      Interesting that they are pursuing dexpramipexole for treatment of ALS. Biogen Idec cancelled the project due to poor results in Phase III of their trials with this very same compound.
       
      • Agree Agree x 1
    5. AUTHOR
      AUTHOR
      attheedgeofscience
      No Mood

      attheedgeofscience Member Benefactor Hall of Fame

      Tinnitus Since:
      Childhood
      Cause of Tinnitus:
      Head Injury
      Presentation by Knopp Biosciences from 2015 (concerning Kv7-channel openers). Several of the researchers working at Knopp are former students of the faculty of chemistry at Pittsburgh University (Prof. Peter Wipf) which jointly produced the research on RL-81 together with Prof. Tzounopoulos.

      Tags: @sharonr @Paulmanlike
       

      Attached Files:

      • Informative Informative x 5
      • Like Like x 2
    6. jer

      jer Member

      Tinnitus Since:
      06/2015
      Cause of Tinnitus:
      Acoustic trauma
      Thank you very much for providing this information and keeping us all updated @attheedgeofscience
       
      • Agree Agree x 3
    7. Mic
      Buzzed

      Mic Member Team Research

      Tinnitus Since:
      04/2014
      Cause of Tinnitus:
      Otitis media / Ear infection
      Good news... but it is still wise not to launch kv7 regulating drugs as the new holy promise of tinnitus treatment.

      Back in 2011 there was an experiment in which Maxipost and it's R-enantiomer (opposite) were both effective in reducing salicylate induced tinnitus in animals. The theory was that the R-enantiomer should induce tinnitus because it opens the gates of kv7.2-7.5 channels. Instead it reduced tinnitus on the same manner as Maxipost.

      Retigabine was a cannon that destroyed tinnitus... but also everything else on his way. Instead of a cannon we need a silver bullet that can be pinpointed exactly to the root of the problem.

      Read more about the Maxipost experiment here:
      https://www.ncbi.nlm.nih.gov/pubmed/21640740
       
      • Like Like x 2
      • Informative Informative x 1

Share This Page

If you have ringing ears then you've come to the right place. We are a friendly tinnitus support board, dedicated to helping you discuss and understand what tinnitus treatments may work for you.