Magnolol Bark Exerts Antiepileptic Effects via the GABA/Benzodiazepine Receptor

Discussion in 'Research News' started by Danny Boy, Mar 20, 2016.

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    1. Danny Boy
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      Danny Boy Member Benefactor Hall of Fame

      Location:
      England
      Tinnitus Since:
      7/2014
      Cause of Tinnitus:
      Ear infection
      Magnolol, a major bioactive constituent of the bark of Magnolia officinalis, exerts antiepileptic effects via theGABA/benzodiazepine receptor complex in mice.

      BACKGROUND AND PURPOSE:
      The aim of this study was to evaluate the anti-convulsant effects of magnolol (6, 6', 7, 12-tetramethoxy-2, 2'-dimethyl-1-β-berbaman, C18H18O2) and the mechanisms involved.

      EXPERIMENTAL APPROACH:
      Mice were treated with magnolol (20, 40 and 80 mg·kg(-1)) 30 min before injection with pentylenetetrazol (PTZ, 60 mg·kg(-1), i.p.). The anti-seizure effects of magnolol were analysed using seizure models of behaviour, EEG and in vitro electrophysiology and c-Fos expression in the hippocampus and cortex.

      KEY RESULTS:
      Magnolol at doses of 40 and 80 mg·kg(-1) significantly delayed the onset of myoclonic jerks and generalized clonic seizures, and decreased the seizure stage and mortality compared with those of the vehicle-treated animals. EEG recordings showed that magnolol (40 and 80 mg·kg(-1)) prolonged the latency of seizure onset and decreased the number of seizure spikes. The anti-epileptic effect of magnolol was reversed by the GABA(A)/benzodiazepine receptor antagonist flumazenil. Pretreatment with flumazenil decreased the effects of magnolol on prolongation of seizure latency and decline of seizure stage. In a Mg(2+)-free model of epileptiform activity, using multi-electrode array recordings in mouse hippocampal slices, magnolol decreased spontaneous epileptiform discharges. Magnolol also significantly decreased seizure-induced Fos immunoreactivity in the piriform cortex, dentate gyrus and hippocampal area CA1. These effects were attenuated by pretreatment with flumazenil.

      CONCLUSIONS AND IMPLICATIONS:
      These findings indicate that the inhibitory effects of magnolol on epileptiform activity were mediated by theGABA(A) /benzodiazepine receptor complex.

      http://www.ncbi.nlm.nih.gov/pubmed/21518336

      Magnolol, a major bioactive constituent of the bark of Magnolia officinalis, induces sleep via the benzodiazepine site of GABA(A) receptor in mice.


      "Magnolia bark extract has powerful stress busting effects, largely due to “honokiol” a well-studied and potent anxiolytic. It works similarly to prescription medications like alprazolam (Xanax), chlordiazepoxide (Librium), diazepam (Valium), and lorazepam (Ativan). Both magnolia and prescription sedatives work by increasing levels of GABA, a relaxing hormone that helps calm and soothe an overactive brain. The difference is that honokiol is picky and works in specific areas of the brain (raising GABA). The net effect is relaxation. Prescription drugs affect GABA receptors throughout your entire body, causing systemic side effects such morning hangover effect, muscle weakness, daytime fatigue and more. Magnolia, being more selective, should not produce these problems, and should not make you feel doped up."

      http://www.ncbi.nlm.nih.gov/pubmed/22771461
       
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    2. DebInAustralia

      DebInAustralia Member Benefactor Team Research

      Location:
      Geelong, Victoria
      Tinnitus Since:
      30/12/13
      If moa is similar to benzo..there may be potential for WD symptoms/worsening of t?
       
    3. Cheza
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      Cheza Member Benefactor

      Location:
      Oregon
      Tinnitus Since:
      04/2014
      Cause of Tinnitus:
      Barking dogs/stress
      It's been around for quite some time. Info on drugs.com. Better info on Examine.com.

      Supplements on Amazon.com. Sounds like a product worth trying. I have a terrible time staying asleep, and often have difficulty falling asleep since tinnitus onset.
       
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    4. undecided
      Fine

      undecided Member

      Location:
      Greece
      Tinnitus Since:
      04/2014
      Cause of Tinnitus:
      Unknown.
      Just keep your money.
      There is a reason why those supplementss are sold freely on Amazon and why benzodiazepines are scheduled drugs.
      My rule of thumb: the illegality of substance X is directly proportional to its effectiveness. It should be an axiom really.
       
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    5. Cheza
      Wishful

      Cheza Member Benefactor

      Location:
      Oregon
      Tinnitus Since:
      04/2014
      Cause of Tinnitus:
      Barking dogs/stress
      I don't know if that's always true. Aspirin is incredibly effective for its intended purposes. If it were discovered in modern times, though, Big Pharma would put a $25 price on each pill.

      I took the time to read a lot of the reviews for this supplement on Amazon and other sites, as well, just to get an overview of its touted efficacy. Seems like either it works or it doesn't. One reviewer mentioned it helped her mother sleep because her mother had a high nighttime cortisol level. Apparently it affects cortisol, which is interesting. Or maybe it just does for that woman, who knows.

      For $15, I'm willing to try it. Maybe I'll be one of the lucky ones. I would love to sleep through the night again. :)
       
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    6. undecided
      Fine

      undecided Member

      Location:
      Greece
      Tinnitus Since:
      04/2014
      Cause of Tinnitus:
      Unknown.
      I was referring to sleeping aids, but yeah, you're right about the aspirin.
      Hope you get some nice sleep with the magnolia. Mix it with some passion flower if it doesn't work at all - you'll definitely feel something, for the first 2-3 days. Tolerance is built extremely fast when using these veggie-sedatives.
       
    7. Cheza
      Wishful

      Cheza Member Benefactor

      Location:
      Oregon
      Tinnitus Since:
      04/2014
      Cause of Tinnitus:
      Barking dogs/stress
      Thanks for the tip. I've read about passion flower but never tried it, so I'll look it up and maybe add that to the mix. So far I've just been using melatonin, magnesium, and a GABA supplement, which I know doesn't cross the BBB, but it does seem to relax me a little bit.

      If magnolia bark packs a punch, I'll save it for the nights when the tinnitus is 9/10 or 10/10. That way the tolerance won't build up.
       
    8. Danny Boy
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      Danny Boy Member Benefactor Hall of Fame

      Location:
      England
      Tinnitus Since:
      7/2014
      Cause of Tinnitus:
      Ear infection

      "Japanese researchers have determined that honokiol and magnolol, two chemicals found in magnolia bark to be up to 1000 times more potent than vitamin e in antioxidant activity"
       
    9. texrat

      texrat Member

      Tinnitus Since:
      1988
      Cause of Tinnitus:
      tire explosion
      Don't be so hasty. I just started using magnolia extract and I can confirm it works exactly like Valium on me: helps sleep, reduces stress and tinnitius intensity. As the original poster revealed, studies are bearing out the benzo behavior of the chief ingredients, magnolol and honokiol.

      I'm still trying to find the right dose for me (somewhere under 100 mg) that helps me sleep but also lets me hear the alarm in the morning. Sleep with this stuff is deeper than that under melatonin for me.
       
    10. Ian Mac

      Ian Mac Member

      Tinnitus Since:
      2011
      Cause of Tinnitus:
      Vestibular Nueritis, loud music (dubstep)
      Fuck yes! That's a legit study, I love this they never test herbs! Where can I buy please??
       
    11. Ian Mac

      Ian Mac Member

      Tinnitus Since:
      2011
      Cause of Tinnitus:
      Vestibular Nueritis, loud music (dubstep)
      Where do you get your extract please ? Would a store like whole foods have it or is online better?
       
    12. gotyoubynuts

      gotyoubynuts Member

      Tinnitus Since:
      10/1990
      Cause of Tinnitus:
      Concert
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    13. Ian Mac

      Ian Mac Member

      Tinnitus Since:
      2011
      Cause of Tinnitus:
      Vestibular Nueritis, loud music (dubstep)
      Sometimes you buy from random people online and you get baby powder instead of what you want..
       
    14. Pleasure_Paulie

      Pleasure_Paulie Member

      Location:
      Australia
      Tinnitus Since:
      06/2016
      Cause of Tinnitus:
      Noise..no idea.. unicorns?
      Has anybody had any success with this at all? The one poster above made his account on the day of his 1 post, so excuse my scepticism regarding another possible herbal remedy.

      Edit. Heck, I just ordered some..Whats money for anyway.... Will report back if these bark pills do a damn thing. PS. I doubt they will.
       
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    15. Danny Boy
      Cheerful

      Danny Boy Member Benefactor Hall of Fame

      Location:
      England
      Tinnitus Since:
      7/2014
      Cause of Tinnitus:
      Ear infection
      Try this, it's more potent-

      https://www.healthmonthly.co.uk/swa...tring=Swanson Superior Herbs Magnolia Extract


      "Magnolia bark has been used in traditional Chinese and Japanese healthcare for thousands of years. Scientific research into its properties began in the 1800s, but only recently did researchers isolate and identify its active component, honokiol. Since then, many investigative studies have been initiated around the world. Historical uses for magnolia bark very widely, with applications for supporting stable moods and promoting healthy stress response being the most consistently recorded and validated. New research is investigating honokiol's potential for promoting cellular health. Our new 90% Honokiol Magnolia Extract meets the standards set for scientific research. You'll find the same high standardisation in supplements sold through health practitioners but at much higher prices."
       
    16. Mentos

      Mentos Member Benefactor

      Tinnitus Since:
      03/2015
      @Danny Boy I did not follow recently your other threads regarding Torbalt / GABA receptor modulators, does above mean that Magnolol has a potential to work similarly to Trobalt on T?
      BTW I remember you reported significant T reduction when using Torbalt, are you still on it? Did the T vanished completely when you used Trobalt? Did it come back / increased in volume when you tappered it off?
       

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