Apologies if there are grammar mistakes, as a Chinese speaker, English is my third language. I developed my T after a neomycin ear drop treatment with a ear drum perforation. Neomycin - the most ototoxic one in aminoglycosides group. A stupid decision from my GP in New Zealand, led to a life time agony. My T induced by antibiotic side effect is catastrophic. Absolutely catastrophic.. I hear my T over everything..There is always several different noises- an ultra high pitched hissing, an unmaskable jet engine buzzing, a loud screaming, feels like my neighbor is sawing steel, all day, every day. Like everyone here, I pray for a cure, hoping it is coming to us soon in future. Human have been on the moon decades ago, but our we still know absolutely very little about tinnitus and we have not done enough. The mechanism still remains very unclear. It has been understood that when hair cells are damaged/dead, they constantly make a "false signal" and fire to our auditory nerve, although some researchers think it might be much deeper in our brain, I personal believe this "signal firing" theory is correct as we already understand that aminoglycosides damage these hair cells, same as what loud noise does. So I believe for most of us, that is the case, it will be something to do with these tiny weak cells. Tinnitus always comes with hearing loss, I agree with that although I only have very minor high frequency hearing drop down, but if you think about it the other way round, there are some people have hearing loss but they do not experience tinnitus at all, some people are totally deaf, to our understandings, they should experience very severe T, as all the cells in all hearing frequency range are firing the signal, but the fact is they don't experience the ringing of all frequencies. I can't imagine how it would be if a fully deaf man hear noises of all frequencies. So apparently, some cell damages appear as tinnitus but some damages only cause hearing loss without firing the annoy signal. Researchers have been trying to find a way to block the signal on the "highway", but I wonder if its possible for us to understand why and how these cells are firing the signals, the difference between the cells actively firing signal and the ones just die quietly, if we can understand the difference that lead to these two results, maybe we can do a lot more. Maybe only the injured ones fire the signals but the totally dead ones don't? We do not know yet. We should know more about tinnitus mechanism instead of finding the key in a dark room. And hopefully, we will.