NervGen Pharma’s NVG-291-R Demonstrates Significant Functional Recovery in DoD-Sponsored Preclinical Models of Traumatic Hearing Loss

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NervGen Pharma's NVG-291-R Demonstrates Significant Functional Recovery in DoD-Sponsored Preclinical Models of Traumatic Hearing Loss

About NVG-291

NervGen holds exclusive worldwide rights to NVG-291, a first- and potential best-in-class neuroreparative therapeutic peptide targeting nervous system repair. NVG-291's technology is licensed from Case Western Reserve University and is based on academic studies that demonstrated the preclinical efficacy of NVG-291-R, the rodent variant of NVG-291, in animal models of spinal cord injury. These studies implicated multiple potential molecular and cellular mechanisms by which NVG-291-R promotes neurorepair and functional improvement in both central and peripheral nervous system injury models. The implicated mechanisms include the promotion of neuronal sprouting, or plasticity, remyelination, and promotion of a non-inflammatory phenotype in the microglial cells. NervGen has received Fast Track designation from the FDA and Orphan Designation from the EMA for NVG-291 in individuals living with spinal cord injury.

• Demonstrated significant hearing restoration in blast-induced sensorineural hearing loss models
• Promoted significant functional recovery and axonal regeneration in peripheral nerve injury models
• Reinforced NVG-291's broad therapeutic potential with new data across three distinct injury models

 

[Joeseph Stope]

Hey! Is this my birthday, Christmas, or what? I never thought they would arrive in the height of summertime!

Before and after my first encounter with tinnitus, I was pretty much in perfect health. That made me believe there must be some simple cause, like a tiny screw loose in my ear that just needed tightening. If only those egghead, nerdy doctors could figure out which one, then I'd be back in shipshape again.

Thirty-three years on, I've learned to be careful with euphoria. While it would be beyond wonderful if the medical community had come up with a simple quick fix for tinnitus and hyperacusis, I'm not celebrating just yet.

Recent findings suggest that the first damage from noise or acoustic trauma occurs to the synapses and maybe the stereocilia. Sorry, I've forgotten the link. More serious damage would be to the hair cells.

This would suggest that the first attempt at a cure might target the synapses, followed by attempts to rejuvenate, regrow, or repair the hair cells.

Maybe I think too logically. But it would be beyond wonderful if your post is heralding the arrival of the cavalry.