OHSU Research Team Successfully Converts Human Skin Cells into Embryonic Stem Cells

Discussion in 'Research News' started by J M, May 19, 2013.

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    1. J M

      J M Member

      Location:
      USA
      Tinnitus Since:
      2012
      • Like Like x 1
    2. Deep
      Balanced

      Deep Member

      Another example of human capabilities going to waste for another 10 - 20 years unless you pay someone privately millions of pounds. Ugggh:blackeye:
       
    3. t-man
      Suicidal

      t-man Member

      Tinnitus Since:
      2009
      I can't wait until this is useful in the next couple of decades.

      Seriously, we see nothing but breakthroughs on here with no foreseen application.
       
    4. J M

      J M Member

      Location:
      USA
      Tinnitus Since:
      2012
      I don't think it's that far off.

      I feel strongly that diabetes will be cured in the not to distant future, and this breakthrough at OHSU may hasten it on...along with cures for a number of other ailments including tinnitus.
       
    5. Hudson
      Cowboy

      Hudson Member Benefactor

      Tinnitus Since:
      2003
      I think any treatments we can hope for with tinnitus will only be in lessening it, not removing it completely. I believe that much of the tinnitus signal is due to the lack of input to the auditory system. When hair cells can be regrown and restored to full functionality, tinnitus will resolve itself I think. So we're probably looking at 10-15 years off for that I'm guessing.

      One thing that is encouraging is how the pace of research has quickened. As time goes by, the pace at which things are discovered and research is conducted will only increase. So maybe 10 years off!

      It was only 10 years ago that people were saying curing deafness through cellular regeneration or replacement was 50 years off. Things have changed drastically within 10 years.

      Another positive aspect of hair cell regeneration is that nature has done it already for us. It works for all non-mammalian vertebrates. The puzzle is already solved, and it's merely figuring out how to turn on or off the right genes. In many other medical areas, that is not the case. That's why I think this particular field looks bright within the coming decade.

      That doesn't do much for us here and now, though. A meaningful treatment may be developed that greatly reduces tinnitus volume or distress for individuals in a time frame that is sooner.
       
      • Like Like x 1
    6. J M

      J M Member

      Location:
      USA
      Tinnitus Since:
      2012
      Forgive my ignorance, but are you referring to birds?

      I know that chickens can repair their hearing if it gets damaged.
       
    7. Hudson
      Cowboy

      Hudson Member Benefactor

      Tinnitus Since:
      2003
      Yes, that includes birds, reptiles, any thing with a spine that isn't a mammal. It would be interesting to see if the same held true for marsupials (think of koalas, kangaroos, platypus etc.) as opposed to placental mammals. I'm guessing they are probably in the same boat as other mammals though.

      You just hear a lot about chickens, zebrafish, and other common animals that can regenerate hair cells because they are easy to work with in a laboratory setting, and they have been studied pretty thoroughly already. If you're a scientist interested in what genes (and promoters for that matter) control regeneration, my guess is that you would want to work with a species that has had it's genome sequenced already. A lot of work is already done for you in that way then.
       
    8. erik
      Breezy

      erik Manager Staff Benefactor

      Location:
      Washington State, USA
      Tinnitus Since:
      04/15/2012
      Cause of Tinnitus:
      Most likely hearing loss
      Sorry, little off topic here, but "cure" is a word thrown around a lot with not that much meaning. Very, very few conditions are actually cured or even hoped to be. However, effective treatments can be had and that is where research plays a big part. The problem with tinnitus and other "lesser" conditions (tinnitus is not that high on the priority list) is that funding is very hard to secure. There is a pretty good article that discusses the challenges of funding research for tinnitus
       
    9. Deep
      Balanced

      Deep Member

      Screw that! If you don't mind me saying ;)

      Over 50 million Americans suffer from T and over 40 million have hearing loss, those stats alone are incredibly high, I could name at least 5 other well known diseases or neurological problems that have gained more recognition and have received more money from treatments BUT have less overall stats.

      A lot of characteristics can and should come into play, for example soldiers coming back from the army with difficulties or simply someone who has been exposed to an area exceeding the legal sound limit, so much money can be pushed for new treatments. What baffles me the most is that fact that many wealthy people suffer from hearing conditions or T and don't share some of there wealth to try and help other people. Instead you have people like me and you donating a tenner here and there which is making the process very slow.

      Ahh you could say my argument is pretty "dreamy" or "brutal" or even wrong but it makes sense to me based on my few months of research! Haha
       
    10. Hudson
      Cowboy

      Hudson Member Benefactor

      Tinnitus Since:
      2003
      You could say the same thing about a lot of conditions that have meaningful treatments. It's not really a question of priority, but whether people within the science community think that a treatment is possible. That's why I'm hopeful about the passage of AM-101 through the Phase III trials. If it gets approved, large pharmaceutical companies will see that treatments are possible and will dump money into research of their own. It's already going on behind the scenes more than we realize, to that extent. If a treatment is found to be effective and approved, it definitely will be a watershed moment. The reason for that being is that it's hard to ignore the numbers like Deep said above. Millions upon millions of people in the United States alone have tinnitus, and most would probably take some form of treatment if it existed. That's a huge untapped market. I think that this coming decade may be a boom time for hearing loss/tinnitus research much the same as the last decade was for Opthamalogy.
       
    11. erik
      Breezy

      erik Manager Staff Benefactor

      Location:
      Washington State, USA
      Tinnitus Since:
      04/15/2012
      Cause of Tinnitus:
      Most likely hearing loss
      I am sure if the major drug companies saw any profit in a T treatment they would be all over it but so far signs of that are nil. You just have small private companies and Universities trying to scrape together funds to do a little research and development. With so many conditions to find a cure for, T has to be pretty low on the list.

      50 million people may have T but 99% aren't bothered by it, don't even know its a problem and therefore ignore it or don't care. Then, there is another minor T group who may be bothered by it for a short term but quickly adjust and it becomes a non-factor. All that is left then are people like us who are even a smaller minority of that 1% who are deeply bothered by it, search the internet for answers and come to these message boards to discuss it, in some cases prolonging our own recovery.

      Hudson, I think you are right in that with hearing loss becoming a larger problem because of a decade of loud iPods, mp3 players, car stereos, phones, movie theaters, loud noise everywhere, there may be a boom for hearing loss funding and research and because T is usually a symptom of hearing loss, funding for T would also increase.

      I do believe there are treatments in the works that will be effective someday. But it slow. Till then, we must do what we can for ourselves and trot on....I am thankful for forums like TT and good people like you all! ;)
       
    12. Karl

      Karl Member Benefactor

      Location:
      Chicago
      Tinnitus Since:
      10/2011
      Erik -
      Well said.

      I've read that 4% of th general population is bothered by tinnitus. In the US, that would be about 12 million people who are bothered by it. But, yeah, I agree that the people who are deeply bothered by it, who search message boards is less.

      When I first got it, I could almost ignore it. Then it got louder after a sinus infection. Then I obsessed, and the thing got a life of it's own, becoming this demon. I agree that using message boards, focusing on it, seems to be the psychological fuel the demon likes to grow on.

      About stem cell research: Recently a doctor (in Germany?) has been curing patients with Meniere''s disease by using stem cells. If that can be done, isn't that regenerating cochlear hair cells? Isn't that the fix we tinnitus sufferers are looking for?
       
    13. dan26
      Frustrated

      dan26 Member

      Tinnitus Since:
      1981
      Cause of Tinnitus:
      complete loss of hearing. motorcycle accident
      i get the ATA newsletter and its a great help in learning whats going on as far as research goes. if you can contribute some money to FIND A CURE!. www.ata.org
       
      • Like Like x 1
    14. James White
      Anime

      James White Member Benefactor

      Location:
      Toulouse, France
      Tinnitus Since:
      April 2013
      Cause of Tinnitus:
      Maybe loud music. Not sure.
      If you are talking about that MMA Professional fighter who got his Meniere cured, his tinnitus is still there but all the rest is gone.

      http://www.mmamania.com/2013/4/18/4...ermany-stem-cell-treatment-cure-ufc-president

      Still pretty much expensive experimental stuff for the moment but seems very very promising for the future of Science in general.
       
    15. Karl

      Karl Member Benefactor

      Location:
      Chicago
      Tinnitus Since:
      10/2011
      Thanks, James. This is exactly the story that I read about.
       
    16. Viktor Salvatore
      Smug

      Viktor Salvatore Member

      Location:
      Las Vegas, Nevada
      Tinnitus Since:
      7-5-11
      Chickens can repair their hearing if damanged? One would think that after eating all these chickens we can therefore automatically get our hearing repaired? Welll..... it made me laugh. But my hearing still sucks!
       
    17. Molan
      No Mood

      Molan Member

      Tinnitus Since:
      2005
      @James White

      Could you reference the source that states that although the Menieres was cured his Tinnitus is still there? I have not heard him say this but I could have missed it.

      Also Dana white is the president of the UFC not a professional fighter.
       
    18. James White
      Anime

      James White Member Benefactor

      Location:
      Toulouse, France
      Tinnitus Since:
      April 2013
      Cause of Tinnitus:
      Maybe loud music. Not sure.

      @Molan
      I think you can ignore my statement for the moment, i think my mind just made that up ! Sorry about that.
       
    19. Molan
      No Mood

      Molan Member

      Tinnitus Since:
      2005
      okay so just to clarify at this present moment in time there is no source to state that Dana white still has Tinnitus. He said he is 100% cured of Menieres and if we take him at his word that means any tinnitus he might of had is gone too.

      As long as we are clear on that as I would hate to extinguish any hope some people might have about this. Karl is correct if this story is accurate then this is essentially the cure we have been looking for. It's a shame that various Tinnitus organisations have not been quick to investigate this issue further.
       

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