Otonomy OTO-311 Phase II Clinical Trial for Tinnitus

[Paulmanlike]

Seems so when their stock dropped 80% awhile back. Not a good sign and if OTO-311 is a similar formulation as AM-101 as I've heard that doesn't sound good either. They seem to be dragging out the trial later and later.

Yeah these things take time. I think like 1/10 drug candidates actually ever make it.

In my opinion, this OTO-311 has a chance of working but only for acute tinnitus. I base this opinion on a similar MoA to AM-101. It was also on actiononhearingloss (I think) that it is only for acute - yet Otonomy have not confirmed this.

Either way the first to get some relief from tinnitus is going to pay off for them and will make all this work worthwhile.

 

[acufenero]

Seems so when their stock dropped 80% awhile back. Not a good sign and if OTO-311 is a similar formulation as AM-101 as I've heard that doesn't sound good either. They seem to be dragging out the trial later and later.

Exactly. I'd expect OTO-311 to be as a failure as AM-101 (by the way, I think it's focused on "acute" tinnitus). I'm way more interested in their hair cell regeneration program.

 

[vermillion]

I'm way more interested in their hair cell regeneration program.

Agreed. I am not interested in OTO-311 either but in the hair-cell reg. + synaptic repair.

 

[Paulmanlike]

I have emailed Otonomy asking if OTO-311 is for chronic or just acute. I will update this thread if any reply.

Based on my limited understanding I think it will be just for acute. But then I can focus on what research is going on to treat us chronics...