Otonomy OTO-413 — Treatment of Hidden Hearing Loss

Discussion in 'Research News' started by Michael Larsen, Jan 9, 2018.

    1. Michael Larsen
      Surfing

      Michael Larsen Member

      Tinnitus Since:
      2000
      Cause of Tinnitus:
      Noice
      http://investors.otonomy.com/phoenix.zhtml?c=234082&p=irol-newsArticle_Print&ID=2325672

      OTO-413 is a sustained exposure formulation of BDNF that has been advanced into IND-enabling activities for the treatment of hidden hearing loss.

      OTO-413 is a proprietary formulation of brain-derived neurotropic factor (BDNF) which is a naturally occurring protein involved in neuron growth and repair.

      Nonclinical studies by Otonomy and other research groups have demonstrated that local administration of BDNF repairs ribbon synapses damaged due to noise trauma or exposure to ototoxic chemicals and restores hearing function.

      Otonomy has initiated nonclinical testing and manufacturing for OTO-413 to support an Investigational New Drug (IND) Application, with a Phase 1/2 clinical trial expected to begin in hearing loss patients in the first half of 2019.

      The initial indication for OTO-413 will be patients with hidden hearing loss, a synaptopathy-related hearing loss characterized by speech-in-noise hearing difficulty. This condition affects nearly 3% of the U.S. population.
       
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    2. acufenero
      Starving

      acufenero Member

      Tinnitus Since:
      August 2014
      Cause of Tinnitus:
      Acoustic trauma
      Cool thing! "Mid 2019" is actually pretty soon, though I wish it all could go even faster.
       
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    3. Rubenslash

      Rubenslash Member

      Location:
      Brussels
      Tinnitus Since:
      04/2016
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      Several
      Appears they are combining phase 1 + 2, does that mean they can directly start phase 3 afterwards without a separate phase 2 study?
       
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    4. Kritish Gooriah
      Buzzed

      Kritish Gooriah Member

      Location:
      Lille (France)
      Tinnitus Since:
      07/2017
      Cause of Tinnitus:
      ear surgery acoustic trauma tmj ETD
      It's possible that the competition find a treatment very fast, from which the package "phase 1+2" or it's for go fast that competition.
       
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    5. Aaron123

      Aaron123 Member

      Tinnitus Since:
      00/0000
      Cause of Tinnitus:
      Irrelevant
      I believe so.
       
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    6. acufenero
      Starving

      acufenero Member

      Tinnitus Since:
      August 2014
      Cause of Tinnitus:
      Acoustic trauma
      By the way, what are your thoughts on this?
       
    7. VRZ78

      VRZ78 Member Benefactor

      Tinnitus Since:
      08/2016
      Cause of Tinnitus:
      Viral Infection
      I don't get why they won't also try this on people with tinnitus and hyperacusis? In the research around this area there are some good belief that this could alleviate hyperacusis and tinnitus.
       
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    8. NatureHiker
      Angelic

      NatureHiker Member

      Potentially treating hearing loss and running clinical trials to measure hearing are extremely easier than doing such for tinnitus and hyperacusis.
       
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    9. Rubenslash

      Rubenslash Member

      Location:
      Brussels
      Tinnitus Since:
      04/2016
      Cause of Tinnitus:
      Several
      Among the participants there will obviously be several tinnitus sufferers and I assume they will be measuring the tinnitus level as well.
       
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    10. VRZ78

      VRZ78 Member Benefactor

      Tinnitus Since:
      08/2016
      Cause of Tinnitus:
      Viral Infection
      True... I just hope they won't have trouble finding people for their trial, as identifying hidden hearing loss seems quite challenging...
       
    11. Contrast

      Contrast Member Benefactor Hall of Fame

      Location:
      Retrovile
      Tinnitus Since:
      late 2017
      Cause of Tinnitus:
      injury from noxious noise
      I think hidden hearing loss can be determined if one can still hear high frequency tones but they sound split and distorted. I imagine if it was more severe more tones across all frequencies would begin to sound split.
       
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    12. VRZ78

      VRZ78 Member Benefactor

      Tinnitus Since:
      08/2016
      Cause of Tinnitus:
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      I doubt it but that's exactly what I have so fingers crossed...
       
    13. parsky

      parsky Member

      Tinnitus Since:
      8/1/17
      Cause of Tinnitus:
      Unknown
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    14. Contrast

      Contrast Member Benefactor Hall of Fame

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      injury from noxious noise
      • Optimistic Optimistic x 4
    15. jer

      jer Member

      Tinnitus Since:
      06/2015
      Cause of Tinnitus:
      Acoustic trauma
      If the neurons are needed to be electrically excitable to survive for us to be able to still have later on, is there something that can be done now to keep them alive? Any ideas people?
       
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    16. fade2black244
      Inspired

      fade2black244 Member Benefactor

      Location:
      TX
      Tinnitus Since:
      03/24/2017
      Cause of Tinnitus:
      Noise Induced
      I can't remember where I read it but it mentioned that the neurons are still alive for decades after the hearing loss. It's just the synapse connecting the neurons to the haircells that die that this medicine will restore. So it gives me a little bit of hope to reduce the T.
       
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    17. parsky

      parsky Member

      Tinnitus Since:
      8/1/17
      Cause of Tinnitus:
      Unknown
      Don't Die. ;) I've heard similar to what face2black said.
       
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    18. fade2black244
      Inspired

      fade2black244 Member Benefactor

      Location:
      TX
      Tinnitus Since:
      03/24/2017
      Cause of Tinnitus:
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      Besides, isn't the neurons being over excited what causes the ringing sensation? Perhaps we only hear the T because the neurons are still alive while others who have hearing loss but not T aren't.
       
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    19. Paulmanlike

      Paulmanlike Member Hall of Fame

      Tinnitus Since:
      2008
      Cause of Tinnitus:
      Noise
      Perhaps this is the case when people have t for years and years and it stop suddenly; the neurons eventually die.
       
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    20. fade2black244
      Inspired

      fade2black244 Member Benefactor

      Location:
      TX
      Tinnitus Since:
      03/24/2017
      Cause of Tinnitus:
      Noise Induced
      Yes. If only there were a test for this...
       
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    21. swc5150

      swc5150 Member

      Tinnitus Since:
      06/2012
      That could be? My low pitched T, that started in the summer of 2014, suddenly went away a year ago. It was a brutal sound that lead me to this website. Whatever the case, it's been a blessing. I can deal with the high-pitched T I'm left with until a treatment comes out.
       
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    22. Paulmanlike

      Paulmanlike Member Hall of Fame

      Tinnitus Since:
      2008
      Cause of Tinnitus:
      Noise
      That's interesting that it went away after 3 years; what caused it may I ask? I wish mine disappeared
       
    23. Rubenslash

      Rubenslash Member

      Location:
      Brussels
      Tinnitus Since:
      04/2016
      Cause of Tinnitus:
      Several
      http://investors.otonomy.com/static-files/2b7ed6d7-7056-48e2-ad6c-f5aeace058e9

      Was looking at the Otonomy presentation of August. Slide 19 clearly shows the efficacy of OTO-413 in an animal study as the synapse count in OTO-413 + noise is much higher than in the noise only situation.

      Slide 21 is also interesting for OTO-6XX (hair cell regeneration).

      From an investment point of view, Otonomy has a cash balance of $100m at the end of June while the market cap is currently $82m which means that for every $ you pay for Otonomy stock, you indirectly get 1,21$ in cash. Might be a really compelling long-term play, but very risky obviously as they will run out of cash somewhere in the future and will have to raise capital again to fund the research.
       
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    24. JohnAdams
      Starving

      JohnAdams Member Benefactor Hall of Fame

      Location:
      here
      Tinnitus Since:
      it started.
      Cause of Tinnitus:
      hearing loss
      • Genius Genius x 4
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    25. JohnAdams
      Starving

      JohnAdams Member Benefactor Hall of Fame

      Location:
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      Tinnitus Since:
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      Cause of Tinnitus:
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      CURCUMIN
       
    26. Paulmanlike

      Paulmanlike Member Hall of Fame

      Tinnitus Since:
      2008
      Cause of Tinnitus:
      Noise
      Not the right time to invest in Otonomy. Look what happened to Auris Medical; well over 90% gone since the IPO.
       
    27. Silvio Sabo
      Pooptoast

      Silvio Sabo Member Benefactor

      Location:
      Gothenburg, Sweden
      Tinnitus Since:
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      Otonomy has a completely different approach. Otonomy is not only in the tinnitus cure business either. They are also pursuing hearing loss with their OTO-4xx program. And they have more than one drug candidate in their pipeline. Also if everyone where to think that way we're never going to see a tinnitus cure.
       
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    28. Rubenslash

      Rubenslash Member

      Location:
      Brussels
      Tinnitus Since:
      04/2016
      Cause of Tinnitus:
      Several
      Lol do you know anything about stocks? First of all, your comparison with Auris does not make any sense. Secondly, all depends on their ability to get one of the products on the market. If yes, this could easily be a tenbagger or more, if no then you are obviously right.
       
    29. Contrast

      Contrast Member Benefactor Hall of Fame

      Location:
      Retrovile
      Tinnitus Since:
      late 2017
      Cause of Tinnitus:
      injury from noxious noise
      Curing hearing loss should cure tinnitus if the tinnitus was caused by hearing loss.
       
    30. JohnAdams
      Starving

      JohnAdams Member Benefactor Hall of Fame

      Location:
      here
      Tinnitus Since:
      it started.
      Cause of Tinnitus:
      hearing loss
      Why would there be a drug for hearing loss and another for hidden hearing loss?
       

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