Palmitoylethanolamide (PEA) — Experiences on What It Does for Pain Hyperacusis?

Discussion in 'Support' started by GBB, Jun 7, 2021.

    1. GBB

      GBB Member Hall of Fame

      Location:
      NYC
      Tinnitus Since:
      2016-2019 (Mild, Cured) 8/2020 (Severe)
      Cause of Tinnitus:
      Virus / Microsuction / Acoustic Trauma
      Hi,

      I have mild to no pain hyperacusis but I wanted to make a post regarding a supplement I have tried, which is also supported by positive lab data, which to me has been effective in reducing inflammation. I fully admit pain hyperacusis is not my primary complaint but I feel for you guys and wondered if anyone has tried Palmitoylethanolamide in case it might actually help.

      A few articles:
      It seems to work by reducing the inflammation and pain response, regardless of the type of pain, in a way similar to a cannabinoid, but more selectively and potentially more powerfully. I have been taking it just to see if it could reduce general inflammation and for me it seems effective, but I wondered if anyone with pain hyperacusis has tried it. I'd love it if this helped someone!

      I have very bad tinnitus and this has not worsened it at all, in fact it seems to help a smidge if anything.
       
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    2. DebInAustralia
      No Mood

      DebInAustralia Member Benefactor Advocate

      Location:
      Geelong, Victoria
      Tinnitus Since:
      30/12/13
      Hi GBB,

      Glad to see the PEA might be helping your tinnitus. Are you still taking it? I am considering taking it for severe cervicogenic headaches, that have become a daily joyful feature over the past month.

      I've known about PEA for several years, but instead opted for stem cells for severe joint pain.

      I am miserable with the pain, but careful not to take something that is going to exacerbate my tinnitus.

      I am currently on Boron, which can drive down inflammatory markers, increase calcium uptake into bones, increase estrogen in menopausal women and increase testosterone (good news for men with EDS).

      Also considering following the Root Cause Protocol to rebalance minerals as per Dr. Mosley.

      If all else fails, it will have to be LDN and/or CBD without THC.
       
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    3. AUTHOR
      AUTHOR
      GBB

      GBB Member Hall of Fame

      Location:
      NYC
      Tinnitus Since:
      2016-2019 (Mild, Cured) 8/2020 (Severe)
      Cause of Tinnitus:
      Virus / Microsuction / Acoustic Trauma
      Yes I take it daily. It seems to help marginally which classes it above 99% of things. That and Kava Kava are the only things which have ever done anything for the tinnitus.
       
    4. Lukee

      Lukee Member Podcast Patron Benefactor Ambassador

      Location:
      Toronto, Canada
      Tinnitus Since:
      01/2021
      Cause of Tinnitus:
      Wim Hof Breathing Exercises
      Hey @DebInAustralia, you should look into Psilocybin as well. Granted, it likely is illegal but it has a strong anti-inflammatory effect and there are a couple of success stories I read about treating cervicogenic headaches and cluster headaches (as well as tinnitus). Recent studies suggest it might even be beneficial for trigeminal neuralgia and similar nerve disorders.

      Aside from that, as you already know, LDN could help as well. I read many people get remission from headaches using LDN with the hypothesis being it’s related to neuro inflammation. You could also try fasting, as there is a friend of the family who has completely cured his debilitating headaches through fasting and diet.
       
    5. MindOverMatter

      MindOverMatter Member

      Location:
      Norway
      Tinnitus Since:
      2004/05
      Cause of Tinnitus:
      Unknown (possibly stress related, and later sound induced)
      @GBB, I took today 2 x 500 mg of PEA due to a terrible headache.

      But after the 2nd dose, about 3 hours later, I felt sort of dizzy and nauseous. Did you ever experience this? Seems like these are some of the known side effects of PEA. The tinnitus has been quite good all day though.
       
    6. EDDTEKK

      EDDTEKK Member

      Location:
      Belgium
      Tinnitus Since:
      1999
      Cause of Tinnitus:
      Infection
      Dirk de Ridder proposed PEA to me in combination with Spirulina. It might have a positive effect on tinnitus. Dosage 400 mg every other day.

      Has anyone ever tried this and what was the result for your tinnitus?
       
    7. AUTHOR
      AUTHOR
      GBB

      GBB Member Hall of Fame

      Location:
      NYC
      Tinnitus Since:
      2016-2019 (Mild, Cured) 8/2020 (Severe)
      Cause of Tinnitus:
      Virus / Microsuction / Acoustic Trauma
      I have not had any nausea, but I'm sorry that happened to you! It would be interesting to see if your tinnitus stayed better and if the nausea persisted.
       
    8. AUTHOR
      AUTHOR
      GBB

      GBB Member Hall of Fame

      Location:
      NYC
      Tinnitus Since:
      2016-2019 (Mild, Cured) 8/2020 (Severe)
      Cause of Tinnitus:
      Virus / Microsuction / Acoustic Trauma
      It seems to help my tinnitus a bit but not enough to cure me.
       
    9. MindOverMatter

      MindOverMatter Member

      Location:
      Norway
      Tinnitus Since:
      2004/05
      Cause of Tinnitus:
      Unknown (possibly stress related, and later sound induced)
      @GBB, PEA, even in a small single dosage of 4-500 mg seems to lower/ease my tinnitus within an hour of consumption. It seems less shrill and less reactive.

      Maybe it's worth to try out over a period of time - if not every day, maybe every other day in small dosage. I didn't feel dizzy unless I doubled the dosage.
       
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    10. Orions Pain
      Sad

      Orions Pain Member Benefactor Hall of Fame

      Tinnitus Since:
      11/2019
      Cause of Tinnitus:
      A series of unfortunate events
      I have been taking this for a little over a week. 800 mg for the last 5 days or so, split up as two 400 mg doses. Might be too soon to tell, but so far it does nothing for my nerve pain nor my tinnitus. I have almost constant level 6-7/10 acid burning pain in the areas supplied by the trigeminal nerve and the occipital nerve for context.

      I also think it has been triggering headaches, and this may not be a direct effect but I have had more issues with falling asleep this week. Going to stick to it for at least a month and will probably do an update in another 3 weeks.
       
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    11. Zugzug

      Zugzug Member Podcast Patron Benefactor Ambassador Hall of Fame Advocate

      Tinnitus Since:
      05/2019
      Cause of Tinnitus:
      Autoimmune hyperacusis from Sjogren's Syndrome
      Going to try this, along with Ambroxol. Purchased Nootropics brand. Thanks for the information.
       
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    12. Zugzug

      Zugzug Member Podcast Patron Benefactor Ambassador Hall of Fame Advocate

      Tinnitus Since:
      05/2019
      Cause of Tinnitus:
      Autoimmune hyperacusis from Sjogren's Syndrome
      To just add some more information:

      A ClinicalTrials.gov search shows that PEA, in micronized and ultra-micronized forms, has been used in at least 30 clinical trials.

      Notably, there are separate ongoing studies involving fibromyalgia (linked to peripheral and central neuroinflammation) and COVID-19.

      With Sjogren's, I should be a good guinea pig. Be nice to me and I won't bite.
       
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    13. Greg Sacramento

      Greg Sacramento Member Benefactor Ambassador Hall of Fame Advocate

      Tinnitus Since:
      April 2011
      Cause of Tinnitus:
      syringing and now somatic T dental work
      I use PEA with limited success - 10-20%. We used it for Sjogren's syndrome and the like - There's many similar like conditions to Sjogren's which I have - joint inflammation - mouth pain - nerve pain - eye pain. Observed - patients --- tends to work better for those who are sentimental - lost hope. It may be that for those with tinnitus/hyperacusis - it helps with nerves of the ears and surrounding areas.
       
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