People with Tinnitus Have More Grey Matter

Discussion in 'Research News' started by nills, Mar 13, 2014.

    1. Autumnly
      Wishful

      Autumnly Member Podcast Patron Benefactor Ambassador Hall of Fame Advocate

      Tinnitus Since:
      07/2013
      Cause of Tinnitus:
      noise-induced
      Altered Topological Patterns of Gray Matter Networks in Tinnitus: A Graph-Theoretical-Based Study
      Xiaofeng Lin, Yueyao Chen, Mingxia Wang, Chao Song, Bingling Lin, Xiaoping Yuan, Qingyu Liu, Haidi Yang and Ningyi Jiang

      Results: Tinnitus was found to have increased global efficiency, local efficiency, and cluster coefficient, indicating generally heightened connectivity of the network. The small-world coefficient remained normal for tinnitus, indicating intact small-worldness. Betweenness centrality analysis showed that hubs in the amygdala and parahippocampus were only found for tinnitus but not controls. In contrast, hubs in the auditory cortex, insula, and thalamus were only found for controls but not tinnitus. Interregional correlation analysis further found in tinnitus enhanced connectivity between the auditory cortex and prefrontal lobe, and decreased connectivity of the insula with anterior cingulate gyrus and parahippocampus.

      Conclusion: These findings provided the first morphological evidence of altered topological organization of the brain networks in tinnitus. These alterations suggest that heightened efficiency of the brain network and altered auditory-limbic connection for tinnitus, which could be developed in compensation for the auditory deafferentation, leading to overcompensation and, ultimately, an emotional and cognitive burden.
       
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