I am considering the following treatment to see if this impacts on the severity of my tinnitus/hyperacusis etc soon. it will consist of Piracetam , which is a nootropic (used to enhance cognition). it is thought that it binds to glutamate receptors as well as the glutamate/gaba ratio. It also helps to enhance blood flow, helps to make cell membranes more fluid; thus allowing neurotransmitters to move from neuron to neuron more rapidly, along with being neuroprotective . It might increase the production of Acetylcholine, which is a nerve signalling neurotransmitter (Research on rats has shown that Piracetam reverses amnesia caused by scopolamine, which blocks acetylcholine) . Piracetam also has a low toxicity profile. My interest in Choline stemmed from reading Professor Kaltenbach's work with linking acetylcholine receptor deactivation with tinnitus. He theorises that activating the (muscarinic) Ach receptors will be a potential modality to pharmaceutically suppress the tinnitus signal. Choline is an essential nutrient, that helps maintain the structure of cell membranes; ensuring the proper functioning of the nervous system. Choline is a precursor to acetylcholine. Piracetam enhances cognitive function by increasing acetylcholine production. So choline and piracetam work synergistically together. I will be combining choline with piracetam to combat the headaches that are a known side effect of piracetam. A common hypothesis why choline helps prevent headaches induced by P is that P stimulates acetylcholine receptors; thus increasing their demand for ach. The headache develops as a result of choline deficiency. I will also be receiving iv phospholipids with my dr. i am not recommending anyone else try this. ( i am under the supervision of an experienced intergrative dr with an interest in neurodegerative conditions) Just thought some of you might be interested. i will make future posts if anyone is interested to hear of my progress with this regime.