PQQ (Pyrroloquinoline quinone) and Neurogenesis

How did the hardcore drugs you took work out for you?

 

Some worked wonders, some were über fails.
If there was some lab that would put in work improving/combining the ones that work, I believe we'd be one step closer towards the end of the tunnel.

 

http://www.ncbi.nlm.nih.gov/pubmed/20432928

If that case occurs; there will be acoustic neuroma on vestibular nerve. That means PQQ may be a trigger of tinnitus, even in healthy subjects.

 

Pray tell how did you reach that conclusion?

 

An acoustic neuroma, also called vestibular schwannoma, is a benign, slow-growing tumor that arises from the Schwann cells forming the sheath (covering) of the vestibulocochlear nerve.

If this supplement promotes the proliferation of Schwann cells, it can cause acoustic neuroma?

 

could you please work over PI3K/Akt pathway? By the way @gotyoubynuts has seen it. And another thing is I am talking about the %1-2 possibility.

 

Schwann cells are not equal to schwannoma.

Schwann cells (TA: Gliocytus periphericus) (named after physiologist Theodor Schwann) or neurolemmocytes are the principal glia of the peripheral nervous system (PNS). Glial cells function to support neurons and in the PNS, also include satellite cells, olfactory ensheathing cells, enteric glia and glia that reside at sensory nerve endings, such as the Pacinian corpuscle. There are two types of Schwann cell, myelinating and nonmyelinating. Myelinating Schwann cells wrap around axons of motor and sensory neurons to form the myelin sheath. The Schwann cell promoter is present in the Downstream region of the Human Dystrophin Gene that gives shortened transcript that are again synthesized in a tissue specific manner.

 

Of course not; but ...
A schwannoma (also known as an "neurilemoma,"[1]:621 "neuroma,"[2] "neurolemoma,"[2] and "Schwann cell tumor"[2]) is a benign nerve sheath tumor composed of Schwann cells,

 

No I think you've misunderstood the context of this specific study. Everything "causes" cancer, in fact right now you're being bombarded with radiation from both space and earth. It's funny because the average person fights off cells gone bad each day.

It takes a little more to get a brain tumor than eating these foods regularly;

 

Wise words, @erik .

The thing is, nature produces whole foods, and by eating them, all the various biochemicals, etc. needed to deliver the benefits, are contained within the food itself.

There are times when prudent supplementation helps. It should be chosen wisely.

Also, here's something to consider: Most supplements, even those from the "better" companies, use magnesium stearate as a "flow agent" in the product. Too much of THAT can cause a harmful biofilm in your body and prevent full absorption and cause all kinds of other "silent" ruckus.

 

Here is a good written article about the potential importance of PQQ;

http://www.altmedrev.com/publications/14/3/268.pdf

I have taken PQQ for two days before stopping as I noticed it completely and severely impacted my sleeping pattern for some reason. I have absolutely no idea why it would but I'm curious to know if anyone else had noticed any tiredness after taking PQQ?

 

Did you take it with nac or other glutathione precursor.

 

Some otoxic drugs decrease glutathione, which is neuroprotective (thats the mechanism behind Tylenol causing T). DebinAustralia is right...cysteine is needed for us to produce glutathione, you can't just supplement with it. 'Everyloop'; PQQ isn't depleting glutathione, it is USED by PQQ for recycle/reuptake....so it's not that simple.

 

Well I'm taking one pill of PQQ a day 20mg with 900mg of NAC and a bunch of other things like ATP and L-Carnitine and Q10 and various vitamins B

PQQ is found in interstellar dust ! pretty cool no ?

Have not noticed any changes since I started it 3 weeks ago , we will see in the coming months .

 

@City John I've been taking PQQ and I have not noticed any changes in sleep. I've actually been sleeping a little bit better recently. I normally take the PQQ in the morning.

 

WoW. So scared of NAC now, just bought a bottle but scared to take it now.

 

From the actual article, not the click-bait you read.

They gave the mice 200mg of NAC per kg per day. How much does a mouse weigh? 1kg? Dunno.
So if you're a healthy, say, 85kg man, you'd have to suck down about 17 kilos of NAC per day in order for the possibility of NAC affecting already existing cancerous cells.

It's well known that antioxidants in high quantities may become pro-oxidants in the body but use a little sense.

 

Thanks for your explanation, I'm a 110kg man so I need way more than 17 kilos of NAC I think.
I will try NAC....hope I have no cancerous cells that I don't know of.

 

just a quick re-check on the math: I think 200 mg per kg makes 17 gram for a 85kg man.

 

Yeah, I went a little over the top there, thanks @Leon909

 

Has anyone else tried this PQQ? Success?

 

Knowing all of this I wonder if a supplement I've been taking called GABA Calm is having a positive or negative effect on neurogenesis?

 

I am interested in supplements for mitochondrial health. I started taking CoQ10 with Vitamin E for like a week and then also started PQQ, and took all three supplements for 3 days.

What followed is a tinnitus spike in my higher pitch tone.

Is there any risk on these supplements causing permanent worsening on tinnitus? I stopped taking them 2 days ago.