Protein Movement of Hair Bundles in the Inner Ear May Preserve Hearing for Life

Discussion in 'Research News' started by Danny Boy, Nov 7, 2015.

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    1. Danny Boy

      Danny Boy Member Benefactor Hall of Fame

      Tinnitus Since:
      Cause of Tinnitus:
      Ear infection
      Protein movement of hair bundles in the inner ear may preserve hearing for life
      Finding holds promise for repairing damaged hearing

      Each single hair bundle within the live zebrafish ear contains fascin 2b fused with green fluorescent protein. In this time coarse, the fascin 2b molecules migrate to other regions of the bundle within 220 seconds.

      Hearing is made possible when hair bundles protruding from the tops of hair cells capture the energy of sound waves, converting them into electrical signals that stimulate the auditory nerve to the brain. These hair bundles are made up of individual hair-like projections, or stereocilia, which sway in unison with other stereocilia, and remain permanently with us throughout our lives. Extremely loud noise can force whipsaw motion of the stereocilia, causing them to be damaged and the resulting hearing loss to be permanent. The prevailing theory had been that these hair bundles were made up of cellular scaffolding proteins that do not change or circulate.

      Scientists at Case Western Reserve University School of Medicine have discovered that the movement of protein within hair cells of the inner ear shows signs of a repair and renewal mechanism.

      The investigator's findings will be showcased as the cover paper in the Nov. 17 edition of Cell Reports and are available now in the online edition of the journal. The discovery paves the way for one day therapeutically manipulating the movement of these proteins in a way that could reverse hearing loss, a condition that affects approximately 15 percent of Americans between the ages of 20 and 69.

      "What was surprising in our research with zebrafish is that proteins move so rapidly, implying that protein movement may be required to maintain the integrity of hair bundles in the inner ear," said senior author Brian McDermott, PhD, associate professor of Otolaryngology-Head and Neck Surgery, Case Western Reserve University School of Medicine. "Our research tells us that constant movement, replacement and adjustment among proteins in the inner ear's hair bundles serve a maintenance and even repair function."

      In their research, School of Medicine investigators discovered that proteins in the hair bundle move at surprisingly fast rates, and this movement could explain why hair bundles last a lifetime. The researchers used a confocal microscope to examine the movement in real time of these proteins within the inner ears of baby zebrafish. The zebrafish at this early state of development are completely transparent, making it possible to view internal organs without dissection, including ear structure.

      "We made movies of the secret inner workings of the hair bundle in a live animal, and what is happening in the ear is amazing and unexpected," McDermott said.

      The researchers discovered that vital proteins, actin and myosin, move at a leisurely pace over the course of hours. On the other hand, fascin 2b moves incredibly fast, in seconds. This research proved that the internal structure of stereocilia is dynamic, that the proteins move frequently rather than being mostly stationary.

      The speed with which fascin 2b moves may facilitate repair of breaks in the actin cables of the hair bundle when the ear is exposed to loud noise. Sound enters the ear at remarkable speeds, causing intense vibrations and back-and-forth movement of the hair bundle at extremely high rates. Investigators found that what appears to make the hair bundle so durable in the face of such forces is the rate of protein turnover, which enables renewal of the hair bundle.

      "It was once thought that most everything within the stereocilia was relatively immobile and static," McDermott said. "We found that the constant, dynamic movement likely contributes to the permanency of the hair bundle structure to last a lifetime, or 70 to 90 years in human terms."

      As a next research step, McDermott's team will determine how the hair bundle may repair itself with such protein movement. The process likely involves fascin 2b but may also involve other proteins. They will continue to visualize this process fully in the transparent zebrafish ear.

      "No one has shown that stereocilia heal themselves, so next we will find out if there is a repair mechanism," he said. "People go deaf from damage to stereocilia in the inner ear. If we figure out ways of manipulating protein dynamics within stereocilia to heal this damage, we would likely be able to diminish hearing loss in humans."
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    2. monacco

      monacco Member

      forte Antoine .monaco
      Tinnitus Since:
      Cause of Tinnitus:
      Every day there are discoveries but nothing really helps us . We are frustrated

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    3. skoupidis

      skoupidis Member

      Tinnitus Since:
      Cause of Tinnitus:
      Acoustic trauma or mvc
      But they seem to find in detail the mechanisms involved. This can only lead (if ever) in a precise treatment for deafness and tinnitus as well. Current experimental procedures such as Genvec's gene therapy are more like a shot in the dark...
    4. Sailboardman

      Sailboardman Member Benefactor

      Tinnitus Since:
      Cause of Tinnitus:
      Sensorineural hearing loss right ear.
      True, they find out more and more about the inner workings of the hearing system, but we need relief now, not 20 years from now.

      Unfortunately, we are living in the initial stages, rather the final stages of research, where all these theories, come together and provide a viable solution.
      • Agree Agree x 1
    5. Nucleo

      Nucleo Member Benefactor

      Tinnitus Since:
      It's hard to fix the thing if you don't how it works in the first place. As of right now, any drug developments for hearing problems are just wild pot shots in the dark.
      • Agree Agree x 1

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