Sensorion, the Specialist in Inner Ear Diseases, to Start Human Clinical Trial Phase

Hi,

I had never heard much about this company before.

→ Sensorion, the Specialist in Inner Ear Diseases, Completes a New Funding Round to Begin the Human Clinical Trial Phase

 

Exciting times for us tinnitus sufferers. Something good has to come out of all these new medicines.

 

This stems from INSERM, the same laboratory who developed models that led to AM-101.

 

The race to be the first with a legitimate treatment continues.

Sometimes I don't mind living in a capitalist society because since we have such a common condition, tons of companies are jumping over themselves to figure out how to make us satisfied

 

This is really exciting news. This is a new H4 receptor antagonist aimed at treating tinnitus going to clinical trials.

The active substance is called SENS-111:

Then they have another one called SENS-218:

(Source)

 

Unfortunately, SENS-111 has been discontinued following disappointing performance in treating acute unilateral vestibulopathy in a Phase 2 trial. "Although the company says its SENS-111 was safe and well tolerated by trial participants, it did not meet the primary endpoint of vertigo intensity."

I wonder if SENS-111 as a tinnitus treatment is still on Sensorion's table. They filed a patent for H4 receptor inhibitors to treat tinnitus in 2018.

 

All these trials are failing left, right and center. It's a shame.

 

It's really not a surprise. Several decades ago I got tinnitus, and walked into the headquarters of the American Tinnitus Association in Portland, Oregon. First thing I read was, "tinnitus is permanent and non treatable", or words to that effect. Quite a blow!

But it is what it is, and inner ear damage is inner ear damage. That becomes a neural feedback sort of loop very quickly. In other words, it becomes hard wired in our brain, and the brain powers the mind. The mind is very associated w/ "hearing" tinnitus, as anyone who has ever spent much time online here or gone to a tinnitus self-help group. Simply bringing our attention to it seems to make it worse.

My mantra is just stay busy, avoid loud noises and eat and stay healthy. I don't hear mine when I'm engaged in something else, "when I'm immersed in it". Nature sounds, especially the ocean or a rapid stream often make me unaware of it. So there is some relief, and there are ways to mask it to a degree. I like to make sure my ears haven't built up earwax in them too, which is a very easy thing to overlook when our tinnitus amps up.

 

Not much of a "Specialist in Inner Ear Diseases" after all, since they haven't done anything for the inner ear after 9 years, lol.

 

I think 95% of Tinnitus Talk members have tinnitus that just can't be ignored.

We would be grateful if we were in your situation, where the tinnitus is so slight that it is always noticeable, but can be ignored when distracted.

 

I can't speak for others, but this is not how it works for me. The tinnitus percept at a given moment is what it is. I can divert my attention away from it, depending on the intensity of the task, but I can go back and forth from paying attention to not paying attention and the percept is the same within a short time span (say under an hour). It changes on its own. Other sounds, time of the day and weather may influence the changes, but it just changes and I am there to "listen" it. The louder it is, the less I can divert my attention.

 

This is my experience as well.

 

Is this the fault of Sensorion?