Susan Shore's Explanation for Tinnitus

Discussion in 'Support' started by Nicholas, Mar 19, 2018.

    1. Nicholas
      Angry

      Nicholas Member

      Tinnitus Since:
      02/2018
      Cause of Tinnitus:
      Nightclub
      I was reading this article (https://newatlas.com/tinnitus-cure-treatment-headset/52854/), and I found this explanation:

      "The brain, and specifically the region of the brainstem called the dorsal cochlear nucleus, is the root of tinnitus," says Susan Shore, the U-M Medical School professor leading the research team. "When the main neurons in this region, called fusiform cells, become hyperactive and synchronize with one another, the phantom signal is transmitted into other centers where perception occurs. If we can stop these signals, we can stop tinnitus. That is what our approach attempts to do."

      Fusiform cells perform several valuable functions under normal conditions. They help us locate where sounds are coming from, and help us tune out noises and sensations related to our own head and neck movements.

      But after exposure to loud noises, these cells can start behaving aberrantly, messing up their timing so they begin to synchronize their signals and fire without a noise to tune out, which results in a perception of sound where none exists. The team decided to try a bimodal auditory/somatosensory stimulation routine to attempt to reset the behaviour of these cells.​


      Is it me, or does it sound different from what I usually read on this forum? Here I read that tinnitus comes from the brain trying to replace lost frequencies, does this article tell the truth?
       
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    2. Ambassador
      Cool

      Ambassador Member

      Location:
      USA
      Tinnitus Since:
      June 2015
      Cause of Tinnitus:
      High frequency hearing loss and lifetime noise exposure
      Does this article tell the truth?

      For those with hearing loss related tinnitus I believe yes.
       
    3. PaulBe

      PaulBe Member Benefactor

      Location:
      Cairns
      Tinnitus Since:
      11/2013
      Cause of Tinnitus:
      Probably sound, though never proven
      Observation-hypothesis-test

      There would be your truth if she can prove her hypothesis (and get someone else to, somewhere else).
       
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    4. JohnAdams
      Festive

      JohnAdams Member Benefactor Hall of Fame

      Location:
      Sector Alpha
      Tinnitus Since:
      May 1st 2018
      Cause of Tinnitus:
      Aspirin Toxicity/Possibly Noise
      Susan Snore.
       
    5. Halsy

      Halsy Member

      Location:
      Toronto
      Tinnitus Since:
      Sept. 2017
      Cause of Tinnitus:
      Abscess tooth
      It's not trying to replace the lost frequencies, it's confused by the loss. Everyone loses their hearing - along with their eyesight and everything else as time marches on - and most won't experience tinnitus. It doesn't know how to let go. It's the brain's way of saying something is wrong and it can't quite figure out how to resolve it.

      Also, don't forget, tinnitus isn't just one thing. It's a culmination of things. Most people actually suffer from Somatosensory Tinnitus In it's simplest terms it's the combination of hearing loss/damage and/or neck problems - C-spine issues and/or TMJ/Jaw issues - trigeminal nerves. Most people have one or two of these issues and still don't get tinnitus. Then you add the straw that breaks the camel's back and off you go. And unfortunately it's a lot easier to start than stop.

      A large part of that is because the brain actually creates new neural pathways to replicate the experience - the same reason you have bad memories you'd like to get rid of but have a hard time doing so. So even when the issue(s) that started the tinnitus are resolved it continues. This causes confusion in the auditory cortex - DCN - and that keeps the fusiform cells misfiring/in a hyperactive state. Like depression and other neurological problems it becomes a self-reinforced negative feedback loop.

      What Dr. Shore and Co. are doing is create a neuromodulation device that interrupts the DCN with microshocks. These microshocks act as a reset button. When you can stop them from misfiring that starts the decay process of the bad neural pathways and ultimately resolves the tinnitus. At least in theory. It's hard to say without seeing her data if this targeted for people just with acoustic damage or not. Somatosensory Tinnitus is a trickier bag because the tinnitus is a result of what's known as neuromuscular inflammation - that combination of causes.

      And that doesn't even account for loss of neuroplasticity, which is also a determining factor in all tinnitus. The good news is neuromodulation actually creates new brain neuroplasticity - same as the Neuromod device or the Helius device which is targeted to MS sufferers. Those really rare times I have that super low day where it's barely there? I can live with that if that's the best it can do. Even if it's not a cure but can stop the bad days, that's solid gold right there. So in basic terms you're looking at brain repair plus brain reset = end of tinnitus. It probably won't be a magic bullet but it'll definitely cure some and it should really help most. So keep your fingers crossed.
       
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    6. JohnAdams
      Festive

      JohnAdams Member Benefactor Hall of Fame

      Location:
      Sector Alpha
      Tinnitus Since:
      May 1st 2018
      Cause of Tinnitus:
      Aspirin Toxicity/Possibly Noise
      So basically it's like pruning away the unneeded neural connections?
       
    7. Selah1281

      Selah1281 Member Benefactor

      Tinnitus Since:
      07/2019
      Cause of Tinnitus:
      Unknown
      The current phase of trials is for somatic tinnitus. I applied, but was rejected due to not having tinnitus for 6 months and clonazepam use. I was told I would need to be off the med for 6 months before being eligible. Which I assume would put me outside the timeframe of acceptance anyway as I told them I’d do it and was told

      “We do not recommend you go off your medication solely for the clinical trial. You would need to be off the medication for 6 months to be considered.
      Thank you.”

      All of these communications were with Jacqueline Kjolhede who also told me:

      “Anyone would be able to use it, but it has been tested on people with mild hearing loss and tinnitus.”

      This was in response to me asking if my having bilateral osteomas that could possibly be the cause of my tinnitus would rule me out as a candidate upon release.

      “I recently have been diagnosed with bilateral osteomas of the IAC. I’m not asking about clinical trials, but would this be exclusion criteria for your device if and when it is released?”

      The above was my exact wording.
       
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    8. Bndsmheowqhe

      Bndsmheowqhe Member

      Tinnitus Since:
      2016
      Cause of Tinnitus:
      Loud noise exposure
      The Susan Shore device isn't intended to be a home run but it will likely be, at a minimum, a stand up double.
       

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